{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:52:39Z","timestamp":1767970359795,"version":"3.49.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tuberculosis (TB) is the world\u2019s leading infectious cause of death, killing millions every year. In Canada, considered a low-incidence country for TB, the burden of the disease is unequally distributed, with most cases of latent tuberculosis infection (LTBI) experienced by newcomers from endemic regions. The purpose of this study was to measure LTBI treatment acceptance and completion outcomes of LTBI treatment at the REACH clinic in Saskatoon, a local refugee clinic providing primary care-based LTBI management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case series by sampling methodology was applied to review patients who visited the REACH clinic between January 2017 and June 2021 and who had an interferon-gamma release assay (IGRA) or tuberculin skin test (TST) done for LTBI screening. Those with positive results were retained for analysis. The LTBI treatment acceptance and completion groups were compared according to demographic variables, WHO regions of origin, year of arrival to Canada, and LTBI treatment regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 523 patients were screened for LTBI, of whom 125 tested positive, leading to a test positivity of 23.9%. The treatment acceptance rate was 84.8%, and the treatment completion rate was 93.3%. All of those who declined treatment were more than 18\u2009years of age (<jats:italic>p<\/jats:italic> = 0.02). Otherwise, treatment acceptance and completion rates did not vary significantly in association with gender, categories of refugees, WHO region of origin, year of arrival to Canada, or LTBI treatment regimen used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The refugee clinic acceptance and completion rates in this study are high and meet Canadian TB standards of care. The multidisciplinary clinic model and community support are important facilitators, which, in combination with shorter treatment regimens, offer a path forward for LTBI management among refugees resettling in low-incidence countries.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2023.1225217","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:42:40Z","timestamp":1698046960000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Community treatment of latent tuberculosis in child and adult refugee populations: outcomes and successes"],"prefix":"10.3389","volume":"11","author":[{"given":"Emily","family":"Harwood-Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen 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Tuberculosis Report 2022. 2.2 Tuberculosis Mortality","year":"2022"},{"key":"ref3","article-title":"Tuberculosis Profile: Canada","year":"2021"},{"key":"ref4","article-title":"Tuberculosis in Canada: Infographic","year":"2021"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1080\/24745332.2022.2033062","article-title":"Chapter 1: epidemiology of tuberculosis in Canada","volume":"6","author":"Mounchili","year":"2022","journal-title":"Can J Res Crit Care Sleep Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1503\/cmaj.110160","article-title":"Tuberculosis in Nunavut: a century of failure","volume":"183","author":"MacDonald","year":"2011","journal-title":"CMAJ"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2991\/jegh.k.190314.002","article-title":"The enduring plague: how tuberculosis in Canadian indigenous communities is emblematic of a greater failure in healthcare equality","volume":"9","author":"Hicks","year":"2019","journal-title":"J Epidemiol Glob Health"},{"key":"ref8","article-title":"The History of Stop TB Canada","year":"2022"},{"key":"ref9","article-title":"How the Partnership Works","year":"2021"},{"key":"ref10","article-title":"WHO Consolidated Guidelines on Tuberculosis, Module 2: Screening \u2013 systematic screening for tuberculosis disease","year":"2021"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1503\/cmaj.150317","article-title":"Tuberculosis elimination in Canada: truce or victory?","volume":"187","author":"Long","year":"2015","journal-title":"CMAJ"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1183\/09031936.00214014","article-title":"Towards tuberculosis elimination: an action framework for low-incidence countries","volume":"45","author":"L\u00f6nnroth","year":"2015","journal-title":"Eur Respir J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"62","DOI":"10.14745\/ccdr.v43i34a01","article-title":"Latent tuberculosis infection: an overview","volume":"43","author":"Kiazyk","year":"2017","journal-title":"Can Commun Dis Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.1503\/cmaj.170817","article-title":"Demographic predictors of active tuberculosis in people migrating to British Columbia, Canada: a retrospective cohort study","volume":"26","author":"Ronald","year":"2018","journal-title":"CMAJ"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1080\/24745332.2022.2035544","article-title":"Chapter 13: tuberculosis surveillance and tuberculosis infection testing and treatment in migrants","volume":"6","author":"Greenaway","year":"2022","journal-title":"Can J Resp Crit Care Sleep Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"E473","DOI":"10.1503\/cmaj.150011","article-title":"Domestic impact of tuberculosis screening among new immigrants to Ontario","volume":"187","author":"Khan","year":"2015","journal-title":"Canada CMAJ"},{"key":"ref17","article-title":"The encyclopedia of Saskatchewan, tuberculosis control","author":"Dudley Barnett","year":"2006"},{"key":"ref18","article-title":"The first ten years. Saskatoon community clinic - history","author":"Gruending","year":"1974"},{"key":"ref19","article-title":"Census Profile, Census of Population","year":"2021"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/24745332.2022.2039498","article-title":"Chapter 6: tuberculosis preventive treatment in adults","volume":"6","author":"Alvarez","year":"2022","journal-title":"Can J Resp Crit Care Sleep Med"},{"key":"ref21","article-title":"Saskatchewan Provincial Tuberculosis Strategy 2013\u20132018","year":"2013"},{"key":"ref22","article-title":"Background Information about refugees","year":"2023"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/24745332.2022.2043055","article-title":"Chapter 9: pediatric tuberculosis","volume":"6","author":"Dwilow","year":"2022","journal-title":"J Resp Crit Care Sleep Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/24745332.2022.2036503","article-title":"Menzies, D chapter 4: diagnosis of tuberculosis infection","volume":"6","author":"Campbell","year":"2022","journal-title":"Can J Res Crit Care Sleep Med"},{"key":"ref25","article-title":"List of Drugs for an Urgent Public Health Need","year":"2023"},{"key":"ref26","article-title":"Drug Shortage Report for Rifadin","year":"2021"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1553-2712.2004.tb01433.x","article-title":"Advanced statistics: understanding medical record review (MRR) studies","volume":"11","author":"Worster","year":"2004","journal-title":"Acad Emerg Med"},{"key":"ref28","article-title":"Minnesota provider guide: latent TB infection (LTBI) treatment completion criteria","year":"2021"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.7326\/0003-4819-156-1-201201030-00006","article-title":"Distinguishing case series from cohort studies","volume":"156","author":"Dekkers","year":"2012","journal-title":"Ann Intern Med"},{"key":"ref30","article-title":"Chapter 6: treatment of latent tuberculosis infection","author":"Menzies","year":"2014"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e7980869","DOI":"10.1155\/2016\/7980869","article-title":"Cooper R.A step toward tuberculosis elimination in a low-incidence country: successful diagnosis and treatment of latent tuberculosis infection in a refugee clinic","volume":"2016","author":"Rennert-May","year":"2016","journal-title":"Can Respir J"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e00057","DOI":"10.3389\/fpubh.2019.00057","article-title":"Integrated Care for Latent Tuberculosis Infection (LTBI) at a primary health Care Facility for Refugees in Winnipeg, Canada: a mixed-methods evaluation","volume":"7","author":"Benjumea-Bedoya","year":"2019","journal-title":"Front Public Health"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1064136","DOI":"10.3389\/fpubh.2022.1064136","article-title":"Introduction of short course treatment for latent tuberculosis infection at a primary care facility for refugees in Winnipeg, Canada: a mixed methods evaluation","volume":"10","author":"Chevrier","year":"2023","journal-title":"Front Public Health"},{"key":"ref34","year":"2016"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e491","DOI":"10.1016\/S2214-109X(18)30073-1","article-title":"Community health and equity of outcomes: the Partners in Health Experience","volume":"6","author":"Palazuelos","year":"2018","journal-title":"Lancet Glob Health"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12879-016-1550-y","article-title":"Initiation and completion rates for latent tuberculosis infection treatment: a systematic review","volume":"10","author":"Sandgren","year":"2016","journal-title":"BMC Infect Dis"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e0267781","DOI":"10.1371\/journal.pone.0267781","article-title":"Impact and benefit-cost ratio of a program for the management of latent tuberculosis infection among refugees in a region of Canada","volume":"17","author":"P\u00e9pin","year":"2022","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s10903-022-01438-1","article-title":"Can primary care drive tuberculosis elimination? Increasing latent tuberculosis infection testing and treatment initiation at a community health center with a large non-U.S.-born population","volume":"25","author":"Tang","year":"2023","journal-title":"J Immigr Minor Health"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"8","DOI":"10.17269\/s41997-018-0028-7","article-title":"Cooper R prevalence of latent tuberculosis infection in Syrian refugees to Canada","volume":"109","author":"Warrington","year":"2018","journal-title":"Can J Public Health"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/idr15020020","article-title":"Communicable diseases prevalence among refugees and asylum seekers: systematic review and Meta-analysis","volume":"15","author":"Taha","year":"2023","journal-title":"Infect Dis Rep"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2023.1225217\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:42:43Z","timestamp":1698046963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2023.1225217\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":40,"alternative-id":["10.3389\/fpubh.2023.1225217"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2023.1225217","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]},"article-number":"1225217"}}