{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:14:40Z","timestamp":1791317680983,"version":"4.3.1"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>Type 2 diabetes mellitus (T2DM) accelerates the progression of periodontitis through diverse pathways. Abnormal immune responses, excessive activation of inflammation, increased levels of advanced glycation end products, and oxidative stress have defined roles in the pathophysiological process of T2DM-associated periodontitis. Furthermore, in the periodontium of diabetic individuals, there are high levels of advanced glycation end-products and glucose. Meanwhile, progress in microbiomics has revealed that dysbacteriosis caused by T2DM also contributes to the progression of periodontitis. <jats:italic>Lactobacillus<\/jats:italic>, owing to its fine-tuning function in the local microbiota, has sparked tremendous interest in this field. Accumulating research on <jats:italic>Lactobacillus<\/jats:italic> has detailed its beneficial role in both diabetes and oral diseases. In this study, we summarize the newly discovered mechanisms underlying <jats:italic>Lactobacillus<\/jats:italic>-mediated improvement of T2DM-associated periodontitis and propose the application of <jats:italic>Lactobacillus<\/jats:italic> in the clinic.<\/jats:p>","DOI":"10.3389\/fpubh.2023.1248518","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T09:21:05Z","timestamp":1701422465000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Mechanism and application of Lactobacillus in type 2 diabetes-associated periodontitis"],"prefix":"10.3389","volume":"11","author":[{"given":"Sisi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.archoralbio.2014.11.008","article-title":"Interrelationship between diabetes and periodontitis: role of hyperlipidemia","volume":"60","author":"Zhou","year":"2015","journal-title":"Arch Oral Biol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and Peri-implant diseases and conditions","author":"Papapanou","year":"2018","journal-title":"J Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/0022034510381902","article-title":"Periodontal disease and incident diabetes: a seven-year study","volume":"90","author":"Ide","year":"2011","journal-title":"J Dent Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/jcpe.12837","article-title":"A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes an update of the EFP-AAP review","volume":"45","author":"Graziani","year":"2018","journal-title":"J Clin Periodontol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"ZE01","DOI":"10.7860\/JCDR\/2015\/15692.6728","article-title":"Acute phase proteins and their role in periodontitis: a review","volume":"9","author":"Polepalle","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/s0074-7696(08)62546-2","article-title":"Cells, solutes, and growth: salt accumulation in plants reexamined","volume":"28","author":"Steward","year":"1970","journal-title":"Int Rev Cytol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3390\/nu14010166","article-title":"Gut microbiota and complications of Type-2 diabetes","volume":"14","author":"Iatcu","year":"2021","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1046\/j.1365-2672.2001.01229.x","article-title":"Lactic acid bacteria from healthy oral cavity of Thai volunteers: inhibition of oral pathogens","volume":"90","author":"Sookkhee","year":"2001","journal-title":"J Appl Microbiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. 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