{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:05:07Z","timestamp":1791378307177,"version":"4.3.2"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Enterococci are usually low pathogenic, but can cause invasive disease under certain circumstances, including urinary tract infections, bacteremia, endocarditis, and meningitis, and are associated with peritonitis and intra-abdominal abscesses. Increasing resistance of enterococci to glycopeptides and fluoroquinolones, and high-level resistance to aminoglycosides is a concern. National antimicrobial resistance (AMR) surveillance data for enterococci from the Middle East and North Africa (MENA) and the Gulf region is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective 12-year analysis of\n                      <jats:italic>N<\/jats:italic>\n                      = 37,909 non-duplicate diagnostic\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      spp. isolates from the United Arab Emirates (UAE) was conducted. Data was generated by routine patient care during 2010\u20132021, collected by trained personnel and reported by participating surveillance sites to the UAE National AMR Surveillance program. Data analysis was conducted with WHONET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Enterococcus faecalis<\/jats:italic>\n                      was the most commonly reported species (81.5%), followed by\n                      <jats:italic>Enterococcus faecium<\/jats:italic>\n                      (8.5%), and other enterococci species (4.8%). Phenotypically vancomycin-resistant enterococci (VRE) were found in 1.8% of\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      spp. isolates. Prevalence of VRE (%VRE) was highest for\n                      <jats:italic>E. faecium<\/jats:italic>\n                      (8.1%), followed by\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      (0.9%). A significant level of resistance to glycopeptides (%VRE) for these two species has been observed in the majority of observed years [\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      (0\u20132.2%), 2010: 0%, 2021: 0.6%] and\n                      <jats:italic>E. faecium<\/jats:italic>\n                      (0\u201314.2%, 2010: 0%, 2021: 5.8%). Resistance to fluoroquinolones was between 17 and 29% (\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      ) and was higher for\n                      <jats:italic>E. faecium<\/jats:italic>\n                      (between 42 and 83%). VRE were associated with higher patient mortality (RR: 2.97), admission to intensive care units (RR: 2.25), and increased length of stay (six excess inpatient days per VRE case), as compared to vancomycin-susceptible\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      spp.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Published data on\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      infections, in particular VRE-infections, in the UAE and MENA region is scarce. Our data demonstrates that VRE-enterococci are relatively rare in the UAE, however showing an increasing resistance trend for several clinically important antibiotic classes, causing a concern for the treatment of serious infections caused by enterococci. This study also demonstrates that VRE were associated with higher mortality, increased intensive care unit admission rates, and longer hospitalization, thus poorer clinical outcome and higher associated costs in the UAE. We recommend the expansion of current surveillance techniques (e.g., local VRE screening), stricter infection prevention and control strategies, and better stewardship interventions. Further studies on the molecular epidemiology of enterococci are needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2023.1275778","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T01:49:46Z","timestamp":1701049786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Epidemiology of vancomycin-resistant enterococci in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data"],"prefix":"10.3389","volume":"11","author":[{"given":"Jens","family":"Thomsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najiba 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