{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:13:29Z","timestamp":1790399609896,"version":"4.1.0"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>Post-acute sequelae of SARS-COV-2 (PASC) is growing in prevalence, and involves symptoms originating from the central neurological, cardiovascular, respiratory, gastrointestinal, autonomic nervous, or immune systems. There are non-specific symptoms such as fatigue, headaches, and brain fog, which cannot be ascribed to a single system. PASC places a notable strain on our healthcare system, which is already laden with a large number of acute-COVID-19 patients. Furthermore, it impedes social, academic and vocational functioning, and impacts family life, relationships, and work\/financial life. The treatment for PASC needs to target this non-specific etiology and wide-ranging sequelae. In conditions similar to PASC, such as \u201cchemo brain,\u201d and prolonged symptoms of concussion, the non-specific symptoms have shown to be effectively managed through <jats:italic>education and strategies for self-management<\/jats:italic> and <jats:italic>Mindfulness<\/jats:italic> interventions. However, such interventions have yet to be empirically evaluated in PASC to our knowledge. In response to this gap, we have developed a virtual education intervention synthesized by psychiatrists and clinical psychologists for the current study. We will undertake a two-phase randomized controlled trial to determine the feasibility (Phase 1; <jats:italic>N<\/jats:italic>\u2009=\u200990) and efficacy (Phase 2; sample sized based on phase 1 results) of the novel 8\u2009week Education and Self-Management Strategies group compared to a mindfulness skills program, both delivered virtually. Main outcomes include confidence\/ability to self-manage symptoms, quality of life, and healthcare utilization. This study stands to mitigate the deleterious intrusiveness of symptoms on everyday life in patients with PASC, and may also help to reduce the impact of PASC on the healthcare system.<\/jats:p><jats:p><jats:bold>Clinical trial registration:<\/jats:bold><jats:ext-link>https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05268523<\/jats:ext-link>; identifier NCT05268523.<\/jats:p>","DOI":"10.3389\/fpubh.2024.1106578","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:15:25Z","timestamp":1707282925000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Self-managing symptoms of Long COVID: an education and strategies research 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