{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:54:16Z","timestamp":1793120056438,"version":"4.5.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study is to study the adverse effects of coal mining environment on workers to discover early effective biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The molecular epidemiological study was conducted with 502 in-service workers, who were divided into miner and auxiliary. We measured the individual levels of dust exposure for participants. Clinical examinations were conducted by qualified doctors. Peripheral blood was collected to measure biochemistry, hemogram, and karyocyte apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All workers were healthy who have not found with any diseases that can be diagnosed medically in the physical examination and showed no difference in dust exposure level, age, height, weight, and body mass index between groups. The working years of miners were lower than that of auxiliaries (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). Compared with auxiliaries, the concentration and percentage of lymphocytes (<jats:italic>p<\/jats:italic>\u2009=\u20090.040, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), basophils (<jats:italic>p<\/jats:italic>\u2009=\u20090.027, <jats:italic>p<\/jats:italic>\u2009=\u20090.034), and red blood cells (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) and the concentration of hemoglobin of miners were lower (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). The percentage of neutrophils (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), the concentration of mean corpuscular hemoglobin concentration (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), and the proportion of karyocyte apoptosis in miners were higher (<jats:italic>p\u2009&amp;lt;<\/jats:italic> 0.001). Miners presented higher blood urea nitrogen (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), ratio of blood urea nitrogen to creatinine (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), the high density lipoprotein cholesterol (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), lower creatinine (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05), and cholesterol (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The coal mining environment impacted mining workers\u2019 immune function, renal function, and the hematopoietic system, including BUN\/CRE, HGB, RBC, and LYMPH, which could be used as early biomarkers to screen the health of coal miners.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1368557","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T13:31:25Z","timestamp":1714397485000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Coal mining environment causes adverse effects on workers"],"prefix":"10.3389","volume":"12","author":[{"given":"Huihui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.26444\/aaem\/106224","article-title":"Factors of work environment hazardous for health in opinions of employees working underground in the 'Bogdanka' coal mine","volume":"26","author":"Strzemecka","year":"2019","journal-title":"Ann Agric Environ Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"7363","DOI":"10.1007\/s10653-023-01583-y","article-title":"The impact of coal mine dust characteristics on pathways to respiratory harm: investigating the pneumoconiotic potency of coals","volume":"45","author":"Kamanzi","year":"2023","journal-title":"Environ Geochem Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"111702","DOI":"10.1016\/j.envres.2021.111702","article-title":"Pollutant source, ecological and human health risks assessment of heavy metals in soils from coal mining areas in Xinjiang, China","volume":"202","author":"Zhang","year":"2021","journal-title":"Environ Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s10661-019-7229-2","article-title":"Coal mine effluent-led bioaccumulation of heavy metals and histopathological changes in some tissues of the catfish Clarias batrachus","volume":"191","author":"Lakra","year":"2019","journal-title":"Environ Monit Assess"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"28204","DOI":"10.1021\/acsomega.0c03977","article-title":"Coal dust-induced systematic hypoxia and redox imbalance among coal mine workers","volume":"5","author":"Batool","year":"2020","journal-title":"ACS Omega"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1038\/s41598-018-20736-z","article-title":"Gasoline particle filter reduces oxidative DNA damage in bronchial epithelial cells after whole gasoline exhaust exposure in vitro","volume":"8","author":"Usemann","year":"2018","journal-title":"Sci Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s40572-021-00328-2","article-title":"Environmental exposures and lung aging: molecular mechanisms and implications for improving respiratory health","volume":"8","author":"Eckhardt","year":"2021","journal-title":"Curr Environ Health Rep"},{"key":"ref8","volume-title":"Specifications of air sampling for hazardous substances monitoring in the workplace","year":"2004"},{"key":"ref9","volume-title":"Method for determination of dust in the air of workplace. 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