{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:27:47Z","timestamp":1787027267225,"version":"build-2736575974"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sarcopenia is a gradually advancing systemic disorder affecting skeletal muscles, primarily distinguished by diminished muscle mass and functional decline. As of present, a universally accepted diagnostic criterion for sarcopenia has yet to be established. From the perspective of the constitution theory in traditional Chinese medicine (TCM), the Yin-deficiency constitution is believed to have a significant correlation with the development of sarcopenia. The primary objective of this study was to examine the potential association between sarcopenia and Yin-deficiency constitution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study is a cross-sectional analysis. The Asian Working Group for Sarcopenia (AWGS) recommended a diagnostic criterion for sarcopenia. A total of 141 participants over 50\u2009years of age were diagnosed with sarcopenia. To determine the constitution of each patient, classification and determination standards were used in traditional Chinese medicine. In this study, a combination of logistic regression and propensity score matching (PSM) was employed to analyze a dataset comprising 1,372 eligible observations. The diagnostic efficacy of the test in distinguishing sarcopenia was assessed through receiver operating characteristic (ROC) curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The relationship between Yin-deficiency constitution and sarcopenia was examined using logistic regression analysis. In the crude model, the odds ratio (OR) was found to be 3.20 (95% confidence interval [CI]: 1.70\u20136.03). After adjusting for various confounding factors, including gender, sex, 6\u2009m walking test\/(m\/s), SMI, and maximum grip strength\/kg, the OR increased to 9.70 (95% CI: 3.20\u201369.38). The associations between seven other biased traditional Chinese medicine (TCM) constitutions and sarcopenia were not found to be statistically significant in the fully adjusted model. The propensity score matching (PSM) analysis yielded consistent results with the logistic regression analysis. Receiver operating characteristic (ROC) curve analysis showed that the AUC of the Yin-deficiency constitution combined with age and gender reached 0.707.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among the nine TCM constitutions examined, the Yin-deficiency constitution demonstrates an independent association with sarcopenia. Yin-deficiency constitution may serve as a potential risk factor for the development of sarcopenia. To establish a causal relationship, further experimental investigations are warranted. The diagnostic performance of sarcopenia is effectively demonstrated by the Yin-deficiency constitution combined with age and gender.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2024.1368933","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T07:59:29Z","timestamp":1721807969000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Traditional Chinese medicine constitution and sarcopenia: a cross-sectional study"],"prefix":"10.3389","volume":"12","author":[{"given":"Chi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirong","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1161\/CIRCULATIONAHA.123.064071","article-title":"Sarcopenia and cardiovascular diseases","volume":"147","author":"Damluji","year":"2023","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/ageing\/afac220","article-title":"Sarcopenia definition, diagnosis and treatment: consensus is growing","volume":"51","author":"Sayer","year":"2022","journal-title":"Age Ageing"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.3346\/jkms.2022.37.e146","article-title":"A review of sarcopenia pathophysiology, diagnosis, treatment and future direction","volume":"37","author":"Cho","year":"2022","journal-title":"J Korean Med Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis","volume":"13","author":"Petermann-Rocha","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1007\/s00261-021-03294-3","article-title":"Sarcopenia: imaging assessment and clinical application","volume":"47","author":"Chianca","year":"2022","journal-title":"Abdom Radiol (NY)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"8677","DOI":"10.3390\/ijerph19148677","article-title":"Management of Type 2 diabetes mellitus in elderly patients with frailty and\/or sarcopenia","volume":"19","author":"Sanz-C\u00e1novas","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.jjcc.2021.10.013","article-title":"Sarcopenia as a comorbidity of cardiovascular disease","volume":"79","author":"Sasaki","year":"2022","journal-title":"J Cardiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"101617","DOI":"10.1016\/j.arr.2022.101617","article-title":"Sarcopenia definition: does it really matter? Implications for resistance training","volume":"78","author":"Smith","year":"2022","journal-title":"Ageing Res Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/jcsm.12981","article-title":"Roles of nutrition in muscle health of community-dwelling older adults: evidence-based expert consensus from Asian working Group for Sarcopenia","volume":"13","author":"Chen","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.19540\/j.cnki.cjcmm.20210817.602","article-title":"Application of metabonomics in study of traditional Chinese medicine syndrome: a review","volume":"47","author":"Lyu","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11882-020-00959-9","article-title":"Traditional Chinese medicine (TCM) and allergic diseases","volume":"20","author":"Chan","year":"2020","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref12","first-page":"12034","article-title":"Application of traditional Chinese medicine syndrome differentiation in identification of body constitution of hypertensive and diabetic patients","volume":"13","author":"Fang","year":"2021","journal-title":"Am J Transl Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"111381","DOI":"10.1016\/j.biopha.2021.111381","article-title":"Traditional Chinese medicine and lung cancer--from theory to practice","volume":"137","author":"Li","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"9006096","DOI":"10.1155\/2022\/9006096","article-title":"TCM constitution analysis method based on parallel FP-growth algorithm in Hadoop framework","volume":"2022","author":"Li","year":"2022","journal-title":"J Healthc Eng"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e24905","DOI":"10.1016\/j.heliyon.2024.e24905","article-title":"Association between the traditional Chinese medicine constitution and metabolic dysfunction-associated fatty liver disease in older people: a cross-sectional study","volume":"10","author":"Shen","year":"2024","journal-title":"Heliyon"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1383082","DOI":"10.3389\/fcvm.2024.1383082","article-title":"Study on the related factors of TCM constitution and hemodynamics in patients with coronary heart disease","volume":"11","author":"Mao","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"690","DOI":"10.19852\/j.cnki.jtcm.2020.04.019","article-title":"Clinical research linking traditional Chinese medicine constitution types with diseases: a literature review of 1639 observational studies","volume":"40","author":"Liang","year":"2020","journal-title":"J Tradit Chin Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1111\/j.1365-2702.2009.02937.x","article-title":"The effect of Chinese food therapy on community dwelling Chinese hypertensive patients with Yin-deficiency","volume":"19","author":"Shen","year":"2010","journal-title":"J Clin Nurs"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s11655-010-0028-9","article-title":"Clinical observation on the endocrinal and immune functions in subjects with yin-deficiency constitution","volume":"16","author":"Wang","year":"2010","journal-title":"Chin J Integr Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"111316","DOI":"10.1016\/j.exger.2021.111316","article-title":"The relationship of CCL4, BCL2A1, and NFKBIA genes with premature aging in women of Yin deficiency constitution","volume":"149","author":"Yu","year":"2021","journal-title":"Exp Gerontol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1123\/japa.2022-0195","article-title":"The effect of physical activity on body constitution and psychological health in older adults: evidence from an analysis of a biobank research database","volume":"31","author":"Chen","year":"2022","journal-title":"J Aging Phys Act"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"S147","DOI":"10.1016\/j.jhep.2021.01.025","article-title":"Sarcopenia and frailty in decompensated cirrhosis","volume":"75","author":"Tandon","year":"2021","journal-title":"J Hepatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"155557","DOI":"10.1016\/j.metabol.2023.155557","article-title":"Sarcopenia in youth","volume":"144","author":"Jung","year":"2023","journal-title":"Metabolism"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.3390\/cells11152359","article-title":"Molecular mechanisms of inflammation in sarcopenia: diagnosis and therapeutic update","volume":"11","author":"Jimenez-Gutierrez","year":"2022","journal-title":"Cells"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1200\/JCO.21.00102","article-title":"Sarcopenia in the older adult with Cancer","volume":"39","author":"Williams","year":"2021","journal-title":"J Clin Oncol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"881","DOI":"10.2147\/DDDT.S446336","article-title":"The efficacy of Chaihu-Guizhi-Ganjiang decoction on chronic non-atrophic gastritis with gallbladder heat and spleen cold syndrome and its metabolomic analysis: an observational controlled before-after clinical trial","volume":"18","author":"Wen","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"728032","DOI":"10.3389\/fendo.2021.728032","article-title":"Syndrome differentiation and treatment regularity in traditional Chinese medicine for type 2 diabetes: a text mining analysis","volume":"12","author":"Dou","year":"2021","journal-title":"Front Endocrinol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s11325-022-02708-w","article-title":"Obstructive sleep apnea hypopnea syndrome in ancient traditional Chinese medicine","volume":"27","author":"Lv","year":"2023","journal-title":"Sleep Breath"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.3390\/nu12051293","article-title":"Sarcopenia: a contemporary health problem among older adult populations","volume":"12","author":"Papadopoulou","year":"2020","journal-title":"Nutrients"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/s41430-020-00737-w","article-title":"Nutrition and traditional Chinese medicine (TCM): a system's theoretical perspective","volume":"75","author":"Zhao","year":"2021","journal-title":"Eur J Clin Nutr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.2147\/NDT.S290692","article-title":"Characteristics of TCM constitution and related biomarkers for mild cognitive impairment","volume":"17","author":"Deng","year":"2021","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1017\/erm.2018.3","article-title":"What has traditional Chinese medicine delivered for modern medicine?","volume":"20","author":"Wang","year":"2018","journal-title":"Expert Rev Mol Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e14684","DOI":"10.1016\/j.heliyon.2023.e14684","article-title":"Alterations in gut microbiota and urine metabolomics in infants with yin-deficiency constitution aged 0-2 years","volume":"9","author":"Zhao","year":"2023","journal-title":"Heliyon"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e41099","DOI":"10.2196\/41099","article-title":"The effectiveness of a traditional Chinese medicine-based Mobile health app for individuals with prediabetes: randomized controlled trial","volume":"11","author":"Chung","year":"2023","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13020-021-00441-2","article-title":"The influence of TCM constitutions and neurocognitive function in elderly Macau individuals","volume":"16","author":"Zhang","year":"2021","journal-title":"Chin Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00404-016-4078-x","article-title":"Traditional Chinese medicine valuably augments therapeutic options in the treatment of climacteric syndrome","volume":"294","author":"Eisenhardt","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jep.2012.01.033","article-title":"Syndrome differentiation in modern research of traditional Chinese medicine","volume":"140","author":"Jiang","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"101747","DOI":"10.1016\/j.arr.2022.101747","article-title":"The effect of Tai chi in elderly individuals with sarcopenia and frailty: a systematic review and meta-analysis of randomized controlled trials","volume":"82","author":"Chia-Yu","year":"2022","journal-title":"Ageing Res Rev"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"109565","DOI":"10.1016\/j.biopha.2019.109565","article-title":"Research progress on traditional Chinese medicine syndromes of diabetes mellitus","volume":"121","author":"Wang","year":"2020","journal-title":"Biomed Pharmacother"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2024.1368933\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T07:59:38Z","timestamp":1721807978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2024.1368933\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,24]]},"references-count":39,"alternative-id":["10.3389\/fpubh.2024.1368933"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2024.1368933","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,24]]},"article-number":"1368933"}}