{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:29:09Z","timestamp":1753892949950,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While overall head and neck cancer incidence decreases due to reduced tobacco and alcohol consumption, the incidence of HPV negative oral cavity squamous cell carcinoma (SCC) is raising in several industrialized countries, especially in non-smoking and non-drinking patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We document a case of gingiva SCC in a 56\u2009years old never-smoker patient reporting low alcohol consumption and unusual occupational solvent exposure. The HPV-negative lesion was surgically removed in 2018, and the patient remains in complete remission 4 years after recurrent surgery in 2019. In 2021, the patient was referred to the occupational cancer consultation. The patient worked as screen printer for 18\u2009years. He reported mouth siphoning every 2\u20133 days to transfer organic solvents (mainly aromatic hydrocarbons and ketones) from containers into smaller recipients, with regular passage of solvents into his mouth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the literature, the frequency of solvent siphoning using mouth is likely to be underestimated. While our review did not find studies reporting longterm consequences to the oral cavity of mouth siphoning, current evidence supports a positive association of upper aero digestive tract SCC with occupational exposures to organic solvents and printing processes. In absence of major extraprofessional factors, the HPV-negative gingiva SCC of this patient might be attributable to the regular occupational oral solvent exposure. While the available evidence remains limited to formally establish a causal relationship, clinicians should investigate this hazardous work practice in patients with OSCC and history of solvent exposures.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1370767","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T16:04:18Z","timestamp":1714665858000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"C\u00e9line","family":"Lamouroux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Brochet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Zrounba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Charbotel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Fervers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1902\/jop.2005.76.10.1798","article-title":"Squamous cell carcinoma presenting as an endodontic-periodontic lesion","volume":"76","author":"Levi","year":"2005","journal-title":"J Periodontol"},{"key":"ref3","first-page":"543","article-title":"Oral cavity, oropharynx, lip, and salivary glands","volume-title":"Schottenfeld and Fraumeni Cancer epidemiology and prevention","author":"Hashibe","year":"2017"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/ijc.33896","article-title":"Diverging incidence trends of oral tongue cancer compared to other head and neck cancers in young adults in France","volume":"150","author":"Deneuve","year":"2022","journal-title":"Int J Cancer"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.radonc.2009.07.015","article-title":"Oral cavity squamous cell carcinoma in 260 patients aged 80years or more","volume":"93","author":"Ortholan","year":"2009","journal-title":"Radiother Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1093\/jnci\/djad169","article-title":"Global epidemiologic patterns of oropharyngeal cancer incidence trends","volume":"115","author":"Zumsteg","year":"2023","journal-title":"J Natl Cancer Inst"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/medsci11020042","article-title":"Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma","volume":"11","author":"Barsouk","year":"2023","journal-title":"Med Sci (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"104551","DOI":"10.1016\/j.oraloncology.2019.104551","article-title":"Global patterns and trends in cancers of the lip, tongue and mouth","volume":"102","author":"Miranda-Filho","year":"2020","journal-title":"Oral Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/ijc.33514","article-title":"The unveiled reality of human papillomavirus as risk factor for oral cavity squamous cell carcinoma","volume":"149","author":"Nauta","year":"2021","journal-title":"Int J Cancer"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.micinf.2014.02.009","article-title":"Viruses and oral cancer. 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