{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:10:10Z","timestamp":1791958210063,"version":"4.3.4"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"Background<\/jats:title>Mental health disorders in patients with multi-drug or rifampicin-resistant tuberculosis (MDR\/RR-TB) receive consistent attention. Anxiety and depression can manifest and may impact disease progression in patients with MDR\/RR-TB. Given the heightened stressors resulting from the COVID-19 pandemic, this scenario is even more concerning.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate the prevalence of and risk factors associated with anxiety and depression among patients with MDR\/RR-TB in southern China.<\/jats:p><\/jats:sec>Methods<\/jats:title>A facility-based cross-sectional study was undertaken at Guangzhou Chest Hospital in southern China, encompassing a cohort of 219 patients undergoing outpatient and inpatient treatment for MDR\/RR-TB. Anxiety and depressive symptoms were assessed using the 7-Item Generalized Anxiety Disorder (GAD-7) scale and Patient Health Questionnaire-9 (PHQ-9). The ramifications of anxiety and depression were examined using univariate and multivariate logistic regression analyses, with odds ratios (ORs) and age- and sex-adjusted ORs (AORs) employed to quantify their influence. All data underwent statistical analysis using SPSS 25.0, with statistical significance established at P<\/jats:italic> &lt; 0.05.<\/jats:p><\/jats:sec>Results<\/jats:title>Two hundred and nineteen individuals with MDR\/RR-TB were included in the study. The prevalence of anxiety and depression was 57.53% (n<\/jats:italic> = 126) and 65.75% (n<\/jats:italic> = 144), respectively, with 33.3% (n<\/jats:italic> = 73) of the participants experiencing both conditions simultaneously. Multivariate logistic regression analysis revealed that an age of 20\u201340 years [anxiety AOR = 3.021, 95% confidence interval (CI): 1.240\u20137.360; depression AOR = 3.538, 95% CI: 1.219\u201310.268], disease stigma (anxiety AOR = 10.613, 95% CI: 2.966\u201337.975; depression AOR = 4.514, 95% CI: 2.051\u201310.108) and poor physical health (anxiety AOR = 7.636, 95% CI: 2.938\u201319.844; depression AOR = 6.190, 95% CI: 2.468\u201315.529) were significant risk factors for moderate levels of anxiety and depression.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We found that individuals with MDR\/RR-TB had an elevated risk of anxiety and depression. To decrease the likelihood of unfavorable treatment outcomes, it is imperative to carefully monitor the psychological wellbeing of patients with MDR\/RR-TB and promptly address any detrimental psychiatric conditions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1372389","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T05:14:49Z","timestamp":1711516489000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and risk factors of anxiety and depression in patients with multi-drug\/rifampicin-resistant 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