{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:11:45Z","timestamp":1773915105641,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803310"],"award-info":[{"award-number":["81803310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the causal relationships between pneumoconiosis and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The random-effects inverse variance weighted (IVW) approach was utilized to explore the causal effects of the instrumental variables (IVs). Sensitivity analyses using the MR-Egger and weighted median (WM) methods were did to investigate horizontal pleiotropy. A leave-one-out analysis was used to avoid the bias resulting from single-nucleotide polymorphisms (SNPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no causal association between pneumoconiosis and SLE, RA or gout in the European population [OR\u2009=\u20091.01, 95% CI: 0.94\u20131.10, <jats:italic>p<\/jats:italic>\u2009=\u20090.74; OR\u2009=\u20091.00, 95% CI: 0.999\u20131.000, <jats:italic>p<\/jats:italic>\u2009=\u20090.50; OR\u2009=\u20091.00, 95% CI: 1.000\u20131.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.55]. Causal relationships were also not found in pneumoconiosis due to asbestos and other mineral fibers and SLE, RA and gout [OR\u2009=\u20091.01, 95% CI: 0.96\u20131.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.66; OR\u2009=\u20091.00, 95% CI: 1.00\u20131.00, <jats:italic>p<\/jats:italic>\u2009=\u20090.68; OR\u2009=\u20091.00, 95% CI: 1.00\u20131.00, <jats:italic>p<\/jats:italic>\u2009=\u20090.20].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that pneumoconiosis may have no causal relationship with the three inflammatory immune diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1373044","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T04:52:20Z","timestamp":1711515140000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["No causal association between pneumoconiosis and three inflammatory immune diseases: a Mendelian 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study"],"prefix":"10.3389","volume":"12","author":[{"given":"Yu-Jie","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang-Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Di","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Gui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Yi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Zhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fimmu.2016.00097","article-title":"Silica, silicosis, and autoimmunity","volume":"7","author":"Pollard","year":"2016","journal-title":"Front Immunol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1136\/ard.2004.022053","article-title":"Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study","volume":"64","author":"Stolt","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"115334","DOI":"10.1016\/j.ecoenv.2023.115334","article-title":"Association between exposure to external airborne agents and autoimmune disease","volume":"263","author":"Lee","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3899\/jrheum.110789","article-title":"Occupational risk factors for systemic lupus erythematosus: a nationwide study based on hospitalizations in Sweden","volume":"39","author":"Li","year":"2012","journal-title":"J Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1539\/joh1959.34.421","article-title":"Relationship between autoimmune diseases and pneumoconiosis","volume":"34","author":"Matsuoka","year":"1992","journal-title":"Sangyo Igaku"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ejim.2010.02.004","article-title":"Rheumatoid pneumoconiosis (Caplan\u2019s syndrome)","volume":"21","author":"Schreiber","year":"2010","journal-title":"Eur J Intern Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1093\/annhyg\/46","article-title":"Rheumatoid pneumoconiosis: a comparative study of autopsy cases between Japan and North America","volume":"46","author":"Honma","year":"2002","journal-title":"Ann Occup Hyg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e001178","DOI":"10.1136\/rmdopen-2020-001178","article-title":"Occupational exposure to inorganic dust and risk of gout: a population-based 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