{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:19:04Z","timestamp":1793362744150,"version":"4.5.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>Ionizing radiation is a significant risk factor for cataracts, but the pathogenesis of radiation-induced cataracts remains incompletely understood. Ferroptosis, an iron-dependent form of programmed cell death discovered in recent years, has gained increasing attention for its role in various diseases. This article systematically reviews research progress on ionizing radiation, ferroptosis, age-related cataracts, and radiation-induced cataracts. It proposes the \u201cferroptosis hypothesis\u201d for the pathogenesis of radiation-induced cataracts. Through ionization and oxidative stress effects, ionizing radiation leads to elevated free iron levels and exacerbated lipid peroxidation in lens cells, activating the ferroptosis pathway and resulting in lens opacity. The involvement of ferroptosis in the development of age-related cataracts suggests that it may also be an important pathogenic mechanism of radiation-induced cataracts. Targeting the ferroptosis pathway may be a novel strategy for preventing and treating radiation-induced cataracts. Furthermore, developing new ferroptosis-specific inhibitors with improved targeting and pharmacokinetic properties is also an essential direction for research on preventing and treating radiation-induced cataracts. The study of ferroptosis provides new insights into the mechanism and management of radiation-induced cataracts, potentially transforming radiation-induced cataracts from \u201cinevitable\u201d to \u201cpreventable and treatable.\u201d<\/jats:p>","DOI":"10.3389\/fpubh.2024.1449216","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T13:57:27Z","timestamp":1723816647000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Ferroptosis: a new perspective on the pathogenesis of radiation-induced cataracts"],"prefix":"10.3389","volume":"12","author":[{"given":"Yufu","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingming","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2015.14","article-title":"Cataract","volume":"1","author":"Lam","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","author":"Chylack","year":"2007"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41433-023-02742-2","article-title":"Space radiation and the potential for early cataract development","volume":"38","author":"Waisberg","year":"2024","journal-title":"Eye"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s10654-018-0450-4","article-title":"Risk of various types of cataracts in a cohort of Mayak workers following chronic occupational exposure to ionizing radiation","volume":"33","author":"Azizova","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1667\/RR0928.1","article-title":"Postoperative cataract cases among atomic bomb survivors: radiation dose response and threshold","volume":"168","author":"Neriishi","year":"2007","journal-title":"Rare"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/oemed-2019-105902","article-title":"Occupational radiation exposure and excess additive risk of cataract incidence in a cohort of US radiologic technologists","volume":"77","author":"Little","year":"2020","journal-title":"Occup Environ Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1016\/j.ijcard.2012.04.124","article-title":"Interventional cardiologists and risk of radiation-induced cataract: results of a French multicenter observational study","volume":"167","author":"Jacob","year":"2013","journal-title":"Int J Cardiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e0164357","DOI":"10.1371\/journal.pone.0164357","article-title":"Risk of cataract incidence in a cohort of Mayak PA Workers following chronic occupational radiation exposure","volume":"11","author":"Azizova","year":"2016","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1148\/radiol.12111947","article-title":"Radiation dose and cataract surgery incidence in atomic bomb survivors, 1986\u20132005","volume":"265","author":"Neriishi","year":"2012","journal-title":"Radiology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reach.2016.11.002","article-title":"Radiation impacts on human health during spaceflight beyond low earth orbit","author":"Freese","year":"2016","journal-title":"REACH"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1667\/RR1580.1","article-title":"NASA study of cataract in astronauts (NASCA). 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