{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:10:58Z","timestamp":1793052658961,"version":"4.5.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The correlation between surrogate insulin resistance (IR) indices and sarcopenic obesity (SO) remains uncertain. This study aimed to assess the association between six IR surrogates\u2014triglyceride-glucose (TyG), TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), triglyceride-to-high-density lipoprotein-cholesterol ratio (TG\/HDL), metabolic score for insulin resistance (METS-IR), and Chinese visceral adiposity index (CVAI)\u2014and SO risk in a middle-aged and older population in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study employed longitudinal data obtained from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015, involving 6,395 participants. We used multivariate logistic regression models to examine the link between six surrogates and SO. Nonlinear relationships were evaluated using restricted cubic spline analysis, and subgroup analyses were conducted for validation. Receiver operating characteristic (ROC) curves were used to assess predictive capabilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the course of a 4-year follow-up period, 319 participants (5.0%) developed SO. In the fully adjusted model, all six surrogates were significantly associated with SO. The adjusted odds ratios (ORs) with a 95% confidence interval (95% CI) per standard deviation increase were 1.21 (1.08\u20131.36) for TyG, 1.56 (1.39\u20131.75) for TyG-WC, 2.04 (1.81\u20132.31) for TyG-WHtR, 1.11 (1.01\u20131.21) for TG\/HDL, 1.67 (1.50\u20131.87) for METS-IR, and 1.74 (1.55\u20131.97) for CVAI. Notably, TyG-WC, TyG-WHtR, TG\/HDL, METS-IR, and CVAI exhibited nonlinear correlations with SO. Conversely, TG\/HDL did not exhibit a significant association during subgroup analysis. Furthermore, TyG-WHtR had a significantly larger area under the receiver operating characteristic curve than other indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicated that TyG, TyG-WC, TyG-WHtR, METS-IR, and CVAI were significantly and positively associated with SO incidence. Meanwhile, TyG-WC, TyG-WHtR, METS-IR, and CVAI showed nonlinear relationships with SO. Specifically, TyG-WHtR may be the most appropriate indicator for predicting SO among middle-aged and older Chinese adults.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1472456","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T05:10:36Z","timestamp":1731906636000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Longitudinal analysis of insulin resistance and sarcopenic obesity in Chinese middle-aged and older adults: evidence from CHARLS"],"prefix":"10.3389","volume":"12","author":[{"given":"Chunyan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hurong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijun","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1016\/j.clnu.2022.10.023","article-title":"Sarcopenic obesity predicts negative health outcomes among older patients with type 2 diabetes: the ageing and body composition of diabetes (ABCD) cohort study","volume":"41","author":"Chuan","year":"2022","journal-title":"Clin Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.4415\/ann_23_03_10","article-title":"Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies","volume":"59","author":"Jurdana","year":"2023","journal-title":"Ann Ist Super Sanita"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1007\/s12603-015-0638-1","article-title":"Sarcopenic obesity and metabolic syndrome in adult Caucasian subjects","volume":"20","author":"Poggiogalle","year":"2016","journal-title":"J Nutr Health Aging"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/ageing\/afw214","article-title":"Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community-dwelling older men: the Concord Health and Ageing in Men Project","volume":"46","author":"Hirani","year":"2017","journal-title":"Age Ageing"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1016\/j.clnu.2019.11.024","article-title":"Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review","volume":"39","author":"Donini","year":"2020","journal-title":"Clin Nutr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/s41574-018-0062-9","article-title":"Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies","volume":"14","author":"Batsis","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"155577","DOI":"10.1016\/j.metabol.2023.155577","article-title":"Interplay of skeletal muscle and adipose tissue: sarcopenic obesity","volume":"144","author":"Park","year":"2023","journal-title":"Metabolism"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1038\/oby.2012.20","article-title":"The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning","volume":"20","author":"Levine","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1365-2265.2012.04433.x","article-title":"Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study","volume":"78","author":"Kim","year":"2013","journal-title":"Clin Endocrinol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/cen.13233","article-title":"Homeostasis model assessment of insulin resistance in a general adult population in Korea: additive association of sarcopenia and obesity 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