{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:37:12Z","timestamp":1789522632127,"version":"build-2803163510"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The growing popularity of active surveillance for papillary thyroid cancer and the COVID-19 pandemic have increased surgery delay, further necessitating a reassessment of the link between surgery delay and survival outcomes for papillary thyroid cancer. In this study, we aim to investigate the interplay among various oncological factors, socioeconomic status, and surgical timing with respect to survival outcomes of papillary thyroid cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 58,378 non-metastatic papillary thyroid cancer patients from 2000 to 2018 were screened from the Surveillance, Epidemiology, and End Results database. Kaplan\u2013Meier survival curve, Cox proportional hazard regression, competing risk hazard regression, and multinomial logistic regression were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Receiving neck dissection or radioactive iodine therapy, being married at diagnosis, living in an urban area, being richer, and being of other minority ethnicity were estimated to be independent predictors for better overall survival. Single, older Black patients living in rural areas that experienced long surgery delays were more associated with a higher non- papillary thyroid cancer mortality rate. High income level was the only independent socioeconomic status predictor for lower papillary thyroid cancer -specific mortality. Unmarried, older patients of minority ethnicity tended to undergo longer surgery delays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgery for non-metastatic papillary thyroid cancer patients can be safely delayed. The elevated non-papillary thyroid cancer mortality has reflected low socioeconomic status population\u2019s survival status.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1488294","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T07:13:04Z","timestamp":1737529984000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Socioeconomic status and delayed surgery: impact on non-metastatic papillary thyroid carcinoma outcomes"],"prefix":"10.3389","volume":"12","author":[{"given":"Kun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e155031","DOI":"10.1172\/JCI155031","article-title":"Health inequity drives disease biology to create disparities in prostate cancer outcomes","volume":"132","author":"Nelson","year":"2022","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1002\/cncr.30431","article-title":"The impact of health insurance on cancer care in disadvantaged communities","volume":"123","author":"Abdelsattar","year":"2017","journal-title":"Cancer"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7542","DOI":"10.1002\/cam4.4276","article-title":"Racial disparities negatively impact outcomes in early-onset colorectal cancer independent of socioeconomic status","volume":"10","author":"Kamath","year":"2021","journal-title":"Cancer Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1097\/ACM.0000000000005181","article-title":"Perspectives on disparities and equity in cancer outcomes: a call to action","volume":"98","author":"Odunsi","year":"2023","journal-title":"Acad Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1023\/A:1011240019516","article-title":"Socioeconomic status and breast cancer incidence in California for different race\/ethnic groups","volume":"12","author":"Yost","year":"2001","journal-title":"Cancer Causes Control"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.3390\/cancers13112820","article-title":"Lung, breast and colorectal Cancer incidence by socioeconomic status in Spain: a population-based multilevel study","volume":"13","author":"Redondo-Sanchez","year":"2021","journal-title":"Cancers"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/lary.24296","article-title":"Temporal trends in oropharyngeal cancer treatment and survival: 1998-2009","volume":"124","author":"Chen","year":"2014","journal-title":"Laryngoscope"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1089\/thy.2013.0090","article-title":"Is lower socioeconomic status associated with more advanced thyroid cancer stage at presentation? 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correlation between tumor size and survival outcomes for parathyroid carcinoma: a SEER population-based cohort study","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Endocrinol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1097\/AS9.0000000000000226","article-title":"Prognostic nomogram and competing risk analysis of death for primary thyroid lymphoma: a long-term survival study of 1638 patients","volume":"3","author":"Zhang","year":"2022","journal-title":"Ann Surg Open"},{"key":"ref24","volume-title":"Cancer registration and surveillance modules: cancer patient follow-up","year":"2023"},{"key":"ref25","volume-title":"SEER combined stage: a cancer staging schema using collaborative stage (CS) to collecting stage using the TNM classification","year":""},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1002\/hed.27758","article-title":"Radioactive iodine therapy improves overall survival outcome in oncocytic 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