{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:36:26Z","timestamp":1768005386916,"version":"3.49.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study is to investigate the risk factors for carbapenem-resistant <jats:italic>Klebsiella pneumoniae<\/jats:italic> (CRKP) infection and death of <jats:italic>K. pneumoniae<\/jats:italic> infections in acute pancreatitis (AP) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of AP patients with <jats:italic>K. pneumoniae<\/jats:italic> infection between January 2019 and April 2024. Logistic regression model was used to determine the risk factors for acquisition of CRKP. Cox proportional hazards regression model was used to identify risk factors for mortality of <jats:italic>K. pneumoniae<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 113 AP patients experienced <jats:italic>K. pneumoniae<\/jats:italic> infections, including 66 with CRKP infection and 47 with CSKP infection. The mortality rate of these patients was 36.3%, with a significantly higher mortality rate in the CRKP group than in the CSKP group (<jats:italic>P<\/jats:italic> &amp;lt; 0.001). Only mechanical ventilation (OR = 2.301; 95% CI 1.02-5.20; <jats:italic>P<\/jats:italic> = 0.045) was the independent risk factor for CRKP infection in patients with AP. Surgery (HR 0.38; 95% CI 0.20\u20130.75; <jats:italic>P<\/jats:italic> = 0.005) and mechanical ventilation (HR 2.93; 95% CI 1.10\u20137.82; <jats:italic>P<\/jats:italic> = 0.032) were the independent risk factors associated with mortality of <jats:italic>K. pneumoniae<\/jats:italic> infection in patients with AP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Klebsiella pneumoniae<\/jats:italic> infection has become a threat to patients with AP. Therefore, implementing preventive and control measures based on risk factors is crucial for the prognosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1533765","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:52:13Z","timestamp":1737096733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis"],"prefix":"10.3389","volume":"12","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1056\/NEJMc1616177","article-title":"Acute pancreatitis","volume":"376","author":"Forsmark Ch","year":"2017","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA."},{"key":"B3","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.pan.2014.09.010","article-title":"A systematic review of the extra-pancreatic infectious complications in acute pancreatitis","volume":"14","author":"Brown","year":"2014","journal-title":"Pancreatology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.pan.2017.01.004","article-title":"Revised Atlanta classification and determinant-based classification: which one better at stratifying outcomes of patients with acute pancreatitis?","volume":"17","author":"Choi","year":"2017","journal-title":"Pancreatology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0005821","DOI":"10.1128\/Spectrum.00058-21","article-title":"Spread of carbapenem-resistant Klebsiella pneumoniae in an intensive care unit: a whole-genome sequence-based prospective observational study","volume":"9","author":"Wei","year":"2021","journal-title":"Microbiol Spectr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.pan.2019.09.008","article-title":"Adverse clinical outcomes associated with multidrug-resistant organisms in patients with infected pancreatic necrosis","volume":"19","author":"Ning","year":"2019","journal-title":"Pancreatology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"221017","DOI":"10.7754\/Clin.Lab.2022.221017","article-title":"Clinical and genomic characteristics of carbapenem-resistant Klebsiella pneumoniae isolates from acute pancreatitis with infection in China","volume":"69","author":"Lin","year":"2023","journal-title":"Clin Lab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1186\/s12879-021-06709-0","article-title":"Predictors of mortality in acute pancreatitis complicated with multidrug-resistant Klebsiella pneumoniae infection","volume":"21","author":"Wu","year":"2021","journal-title":"BMC Infect Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/SHK.0000000000001371","article-title":"Risk factors of multidrug resistant pathogens induced infection in severe acute pancreatitis","volume":"53","author":"Li","year":"2020","journal-title":"Shock."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.2147\/IDR.S410397","article-title":"Clinical characteristics, drug resistance, and risk factors for death of Klebsiella pneumoniae infection in patients with acute pancreatitis: a single-center retrospective study from China","volume":"16","author":"Jia","year":"2023","journal-title":"Infect Drug Resist."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s40121-022-00624-w","article-title":"Risk factors for mortality among critical acute pancreatitis patients with carbapenem-resistant organism infections and drug resistance of causative pathogens","volume":"11","author":"Wu","year":"2022","journal-title":"Infect Dis Ther."},{"key":"B12","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1186\/s12879-021-06275-5","article-title":"Prevalence and risk factors associated with multi-drug resistant organisms (MDRO) carriage among pediatric patients at the time of admission in a tertiary care hospital of a developing country. 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