{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:51:40Z","timestamp":1790272300209,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multimorbidity of chronic diseases has become an increasingly serious public health problem. However, the research on the current situation of multimorbidity in the older adults in Jiangsu, China is relatively lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We surveyed a total of 229,926 inpatients aged above 60 and with two or more chronic diseases in the First Affiliated Hospital with Nanjing Medical University from January 1, 2015 to December 31, 2021. The Apriori algorithm was used to analyze the association rules of the multimorbidity patterns in old adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of these patients was 72.0\u202f\u00b1\u202f8.7\u202fyears, and the male-to-female ratio was 1: 1.53. These patients during the COVID-19 period (from 2020 to 2021) displayed younger, higher male rate, shorter median length of hospital stay, higher \u22656 multimorbidities rate and lower median cost than those not during the COVID-19 period (from 2015 to 2019). In all of these patients, the top 5 chronic diseases were \u201cHypertensive diseases (I10-I15),\u201d \u201cOther forms of heart disease (I30-I52),\u201d \u201cDiabetes mellitus (E10-E14),\u201d \u201cischaemic heart diseases (I20-I25)\u201d and \u201cCerebrovascular diseases (I60-I69).\u201d The complex networks of multimorbidity showed that Hypertensive diseases had a higher probability of co-occurrence with multiple diseases in all these patients, followed by diabetes mellitus, other forms of heart disease, and ischaemic heart diseases (I20-I25).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, the patterns of multimorbidity among the aged varied by COVID-19. Our results highlighted the importance of control of hypertensive diseases, diabetes, and heart disease in most periods. However, during the pandemic period, we should pay more attention to diseases that require urgent treatment, such as malignant tumors. For different periods, the spectrum of diseases we focus on should change accordingly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1473572","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:13:37Z","timestamp":1740528817000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Multimorbidity characteristics in older adults and their associated factors in complex networks: a cross-sectional 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study","volume":"68","author":"Cassell","year":"2018","journal-title":"Br J Gen Pract"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1159\/000532060","article-title":"Early-life factors and multimorbidity risk later in older age: evidence based on CHARLS","volume":"69","author":"Zhao","year":"2023","journal-title":"Gerontology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10198-013-0499-7","article-title":"Association between fee-for-service expenditures and morbidity burden in primary care","volume":"15","author":"Kristensen","year":"2014","journal-title":"Eur J Health Econ"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/RMHP.S97248","article-title":"Multimorbidity in chronic disease: impact on health care resources and costs","volume":"9","author":"McPhail","year":"2016","journal-title":"Risk Manag Healthc 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