{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:22:22Z","timestamp":1792930942688,"version":"4.5.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Exploring modifiable and non-modifiable determinants\u2014like sex of new-borns, maternal characteristics, and lifestyle\u2014of maternal and child health is a priority in Public Health. Understanding these sex-based differences is essential for tailored care and informed public health policies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study aimed to delineate sex disparities in delivery and neonatal characteristics within the \u201cMAMI MED\u201d cohort, an ongoing prospective study involving mother\u2013child pairs from Catania, Italy. The analysis included 1,090 mother\u2013child pairs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The comparison of birth weight and birth length distribution showed some differences between sexes, confirmed by higher birth weight (<jats:italic>\u03b2<\/jats:italic>\u202f=\u202f0.121; 95% CI = 0.071\u20130.172) and greater birth length (<jats:italic>\u03b2<\/jats:italic>\u202f=\u202f0.659; 95% CI = 0.360\u20130.958) in males compared to females. However, the comparison of small and adequate for gestational age (SGA vs. AGA) revealed that the likelihood of being SGA was higher in males than in females (OR = 1.592; 95% CI = 1.005\u20132.563).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Thus, the focus should be on improving the assessment of gender-based differences in diagnostic criteria and incorporating gender-specific aspects into existing preventive guidelines to deeply understand the effect of gender disparities and risk factors on maternal-child health.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1498125","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T11:25:28Z","timestamp":1737977128000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex differences in delivery and neonatal characteristics of new-borns from the \u201cMAMI-MED\u201d cohort"],"prefix":"10.3389","volume":"13","author":[{"given":"Roberta","family":"Magnano San Lio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Barchitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Maugeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Campisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Favara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Ojeda","family":"Granados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"La Mastra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara","family":"La Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Galvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ettore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ettore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Agodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.amepre.2012.02.012","article-title":"A population approach to precision medicine","volume":"42","author":"Khoury","year":"2012","journal-title":"Am J Prev Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2054358116688227","DOI":"10.1177\/2054358116688227","article-title":"Changing paradigms in the Management of Rejection in kidney transplantation: evolving from protocol-based care to the era of P4 medicine","volume":"4","author":"Maier","year":"2017","journal-title":"Can J Kidney Health Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/embor.2012.87","article-title":"Sex and gender differences in health. 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