{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:17:22Z","timestamp":1782742642112,"version":"3.54.5"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to evaluate the health economics of hand-foot-mouth disease enterovirus 71 (EV71) vaccination for the population of appropriate age in Guangdong Province.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A SEIR model was constructed, and a group of differential equations was established. The incidence data of HFMD in Guangdong from January to June 2017 were used to fit the model and the basic reproduction value (R<jats:sub>0<\/jats:sub>) of this disease was simulated. Then, the incidence of HFMD under different vaccination coverage rate (0, 40, 70, and 90%) was simulated in four scenarios. Cost-effectiveness analysis was used to evaluate the health economics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The self-funded voluntary EV71 vaccination strategy implemented in Guangdong Province has effectively reduced the disease economic burden of EV71-type HFMD, and the disease economic burden saved during the peak seasonal segment of HFMD in 2017 was $1,080,000. Meanwhile, Scenario 2, 3, and 4 would each result in a cumulative reduction of 6,525, 9,556, and 10,989 confirmed cases, respectively, with net monetary benefits of approximately $6.55 million, $9.59 million, and $11.2 million. The study results show that the current vaccine pricing is not cost-effectiveness, while the vaccine price is lower than $13.15, EV71 vaccination in Guangdong Province has a cost-effectiveness advantage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vaccination can reduce the incidence of HFMD caused by EV71, which helps to improve the status of HFMD and decreases the disease burden.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1514501","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:26:51Z","timestamp":1747891611000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Health economic evaluation of EV71 vaccination in children under the school-age population in Guangdong Province, China"],"prefix":"10.3389","volume":"13","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jienan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.13604\/j.cnki.46-1064\/r.2021.02.10","article-title":"Epidemiological characteristics of hand-foot-mouth disease before and after the introduction of EV71 vaccine in Baiyun District, Guangzhou","volume":"21","author":"Wang","year":"2021","journal-title":"Chin Trop Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3760\/cma.j.issn.1674-2397.2018.03.001","article-title":"National Health and wellness Commission of the People's Republic of China. 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