{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:28:04Z","timestamp":1784867284791,"version":"3.55.0"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reduced physical mobility is common in older adults and is associated with adverse outcomes, including functional decline, depression, social isolation, and poor nutritional status. Group-based programs focusing on physical activity and nutrition to support healthier lifestyles have demonstrated benefits, particularly when paired with social engagement activities. This paper presents the protocol for a randomized controlled trial (RCT) to test a lifestyle intervention called <jats:bold>EMBOLDEN<\/jats:bold>: a multifaceted intervention aimed at <jats:bold>E<\/jats:bold>nhancing physical and community <jats:bold>M<\/jats:bold>o<jats:bold>B<\/jats:bold>ility in <jats:bold>OLDE<\/jats:bold>r adults with health inequities using commu<jats:bold>N<\/jats:bold>ity co-design. EMBOLDEN is a co-designed 3-month intervention to improve quality of life by incorporating physical activity, healthy eating, social participation, and system navigation. Participants receiving the EMBOLDEN intervention plus usual care are expected to show improvement in physical activity and other health outcomes compared to receiving usual care alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a 2-arm Type II hybrid effectiveness-implementation pragmatic RCT. Eligibility criteria include older adults (55+ years), community-dwelling in urban neighborhoods facing health inequities, able to speak or understand English or Mandarin (or access to family\/friend interpreters), and able to walk 10\u202fm unassisted by another person (assistive devices permitted). Participants will be randomized to the intervention or control arm (1:1 ratio). The intervention arm is usual care plus: (1) 12 weekly group-based sessions to increase knowledge\/skills and behavior activation related to physical activity, healthy eating, fostering social connections and community resources; and (2) up to three tailored individual system navigation sessions. The control arm is usual care, in which participants identify and access services without research support. The primary outcome is time spent doing moderate-to-vigorous physical activity. Secondary outcomes will also be explored, including quality of life, life space mobility, depressive symptoms, nutritional risk, and loneliness. Data will be collected at baseline, 3\u202fmonths (post-intervention) and 6\u202fmonths. Mixed effects models will be used to analyze outcomes, intention-to-treat analysis will be employed, and multiple imputation will address missing data. Descriptive and qualitative data from participants, interventionists, and research documentation will be used to examine adaptations and implementation barriers\/facilitators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>A community-based, co-designed lifestyle intervention may improve physical activity and other health outcomes in older adults living in neighborhoods with health inequities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:uri>ClinicalTrials.gov<\/jats:uri>, NCT05008159.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1555222","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:11:41Z","timestamp":1745467901000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Study protocol for the randomized controlled trial of EMBOLDEN: a multifaceted intervention aimed at Enhancing physical and community MoBility in OLDEr adults with health inequities using commuNity co-design"],"prefix":"10.3389","volume":"13","author":[{"given":"Rebecca","family":"Ganann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Neil-Sztramko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Kuspinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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evaluation","volume":"46","author":"Washburn","year":"1993","journal-title":"J Clin Epidemiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1046\/j.1532-5415.2003.51512.x","article-title":"Measuring life-space mobility in community-dwelling older adults","volume":"51","author":"Baker","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"iv86","DOI":"10.1093\/ageing\/afad119","article-title":"Assessing the measurement properties of life-space mobility measures in community-dwelling older adults: a systematic review","volume":"52","author":"Kuspinar","year":"2023","journal-title":"Age Ageing"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1093\/ptj\/85.10.1008","article-title":"Assessing mobility in older adults: the UAB study of aging life-space assessment","volume":"85","author":"Peel","year":"2005","journal-title":"Phys Ther"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/sj.ejcn.1602225","article-title":"Validity and reliability of SCREEN II (seniors in the community: risk evaluation for eating and nutrition, version II)","volume":"59","author":"Keller","year":"2005","journal-title":"Eur J Clin Nutr"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1891\/1061-3749.9.2.151","article-title":"Reliability and validity testing of the revised 12-item short-form health survey in older adults","volume":"9","author":"Resnick","year":"2001","journal-title":"J Nurs Meas"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1007\/s11136-012-0322-4","article-title":"Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: a multi-country study","volume":"22","author":"Janssen","year":"2013","journal-title":"Qual Life Res"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/2050-7283-1-25","article-title":"Validation and development of a shorter version of the resilience scale RS-11: results from the population-based KORA\u2013age study","volume":"1","author":"Von Eisenhart","year":"2013","journal-title":"BMC Psychol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10433-010-0144-6","article-title":"The De Jong Gierveld short scales for emotional and social loneliness: tested on data from 7 countries in the UN generations and gender surveys","volume":"7","author":"De Jong","year":"2010","journal-title":"Eur J Ageing"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1093\/geronb\/gbn032","article-title":"Assessing outcome expectations in older adults: the multidimensional outcome expectations for exercise scale","author":"Wojcicki","year":"2009","journal-title":"J Gerontol Ser B Psychol Sci Soc 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