{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:03:10Z","timestamp":1792735390688,"version":"4.5.0"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Air pollution is a significant global health concern, particularly for younger children who are especially susceptible to its adverse effects. Pollutants such as particulate matter (PM), nitrogen oxides (NO and NO\u2082), sulfur dioxide (SO<jats:sub>2<\/jats:sub>), ozone (O<jats:sub>3<\/jats:sub>), and carbon monoxide (CO) are associated with increased risks of upper respiratory tract infections (URTI) and lower respiratory tract infections (LRTI). While this association is well-documented, there are critical gaps in understanding the magnitude of these risks, the roles of specific pollutants, and the influence of age, sex, and exposure duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To confirm the relationship between air pollution and respiratory tract infections in children and to identify areas for further research on reducing pollution-related respiratory damage, a literature review was conducted using the MEDLINE\/PubMed database for studies published from January 2000 to December 2024. Eligible studies included randomized controlled trials, cohort studies, and meta-analyses focusing on the relationship between air pollution and respiratory infections in children. Studies were grouped by pollutant type, exposure timing, and infection type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature analysis confirmed that pollution significantly increases the risk of URTI and LRTI in children, with infants and young children being the most vulnerable. Potential mechanisms for the development of respiratory tract pollution-related diseases include the promotion of oxidative stress, induction of inflammatory responses, deregulation of the immune system, and genetic alterations. Prenatal exposure significantly alters respiratory tract development, increasing the risk of LRTI and acute otitis media (AOM) early in life. Both short-term and long-term postnatal exposures can cause severe and recurrent LRTIs, reducing quality of life and leading to frequent hospitalizations and early death. However, the available data do not allow for precise definition of the magnitude of the risk, the individual and combined roles of specific pollutants, and the influence of factors such as age, sex, duration, and site of exposure on the development and severity of respiratory infections. Inconsistent findings on pollutant combinations and specific diseases like otitis media highlight the need for further research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Air pollution is a major risk factor for respiratory infections in children, both prenatal and postnatal exposure can have significant negative impact. However, present knowledge is inadequate to develop effective preventive and therapeutic measures. Further studies are needed to minimize these cultural limits. In particular, it is necessary to delve deeper into how the various pollutants circulate, how they interact with each other, and how they are influenced by climate change and other environmental drivers. Results of these key researches can be translate into clinical and public health practice capable to help protect and improve children\u2019s environmental health.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1567206","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:43:49Z","timestamp":1745930629000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["How air pollution fuels respiratory infections in children: current insights"],"prefix":"10.3389","volume":"13","author":[{"given":"Susanna","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Fainardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Titolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lazzara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialaura","family":"Menzella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Campana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Argentiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Principi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref1","article-title":"From 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Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"20143085","DOI":"10.1098\/rspb.2014.3085","article-title":"Evolution of the immune system in humans from infancy to old age","volume":"282","author":"Simon","year":"2015","journal-title":"Proc Biol Sci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1164\/rccm.2111021","article-title":"Association between air pollution and lung function growth in southern California children: results from a secondcohort","volume":"166","author":"Gauderman","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1056\/NEJMoa040610","article-title":"The effect of air pollution on lung development from 10 to 18 years of age","volume":"351","author":"Gauderman","year":"2004","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(07)60037-3","article-title":"Effect of 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Effects on pulmonary function","volume":"159","author":"Peters","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1164\/ajrccm.164.11.2102005","article-title":"Respiratory effects of relocating to areas of differing air pollution levels","volume":"164","author":"Avol","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1289\/ehp.1205961","article-title":"Long-term exposure toPM10 and NO2 in association with lung volume and airwayresistance in the MAAS birth cohort","volume":"121","author":"Molter","year":"2013","journal-title":"Environ Health Perspect"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1164\/rccm.200510-1678OC","article-title":"Lung function growth in children with long-term exposure to air pollutants in Mexico City","volume":"176","author":"Rojas-Martinez","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3109\/02770903.2011.570407","article-title":"Outdoor air pollution and asthma in children","volume":"48","author":"Tzivian","year":"2011","journal-title":"J Asthma"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2000147","DOI":"10.1183\/13993003.00147-2020","article-title":"Air pollution and the development of asthma from birth until young adulthood","volume":"56","author":"Gehring","year":"2020","journal-title":"Eur Respir J"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"110493","DOI":"10.1016\/j.envres.2020.110493","article-title":"Traffic-related organic and inorganic air pollution and risk of development of childhood asthma: a meta-analysis","volume":"194","author":"Han","year":"2021","journal-title":"Environ Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"740800","DOI":"10.3389\/fpubh.2021.740800","article-title":"Global burden of respiratory diseases attributable to ambient particulate matter pollution: findings from the global burden of disease study 2019","volume":"9","author":"Wu","year":"2021","journal-title":"Front Public Health"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1471-2466-14-130","article-title":"Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma","volume":"14","author":"Esposito","year":"2014","journal-title":"BMC Pulm Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"10074","DOI":"10.3390\/su141610074","article-title":"Airborne nanoparticles (PM0.1) in southeast Asian cities: a review","volume":"14","author":"Phairuang","year":"2022","journal-title":"Sustain For"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3390\/atmos14010066","article-title":"Ambient nanoparticles (PM0.1) mapping in Thailand","volume":"14","author":"Phairuang","year":"2023","journal-title":"Atmos"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.4209\/aaqr.2017.09.0340","article-title":"On the morphology and composition of particulate matter in an urban environment","volume":"18","author":"Zeb","year":"2018","journal-title":"Aerosol Air Qual Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.1021\/es103563z","article-title":"Intake fraction for particulate matter: recommendations for life cycle impact assessment","volume":"45","author":"Humbert","year":"2011","journal-title":"Environ Sci Technol"},{"key":"ref27","article-title":"Global air quality guidelines: particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide","year":"2024"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"139870","DOI":"10.1016\/j.chemosphere.2023.139870","article-title":"Residential combustion of coal: effect of the fuel and combustion stage on emissions","volume":"340","author":"Vicente","year":"2024","journal-title":"Chemosphere"},{"key":"ref29","article-title":"United States Environmental Protection Agency. 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and air pollution exposure","volume":"2011","author":"Lodovici","year":"2011","journal-title":"J Toxicol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.3390\/ijms24054345","article-title":"Outdoor air pollution and childhood respiratory disease: the role of oxidative stress","volume":"24","author":"Dondi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/j.tiv.2010.08.017","article-title":"Endotoxin and polycyclic aromatic hydrocarbons in ambient fine particulate matter from Fresno, California initiate human monocyte inflammatory responses mediated by reactive oxygen species","volume":"24","author":"den Hartigh","year":"2010","journal-title":"Toxicol In Vitro"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1743-8977-7-18","article-title":"Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine 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