{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:40:34Z","timestamp":1764139234294,"version":"3.46.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While international cooperation in blood donor safety surveillance is growing, data from China\u2019s national network remains unpublished. We have established a national donor hemovigilance system to collect data and analyze the current state of blood donor safety in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study on donor hemovigilance data reported to the national network from 2020 to 2022 in China. Demographic information and data on adverse donor reactions (ADRs) among blood donors were collected from 85 Blood Services. R software (version 4.2.3) was used for all statistical analyses. Frequency and composition rates were used to describe the data of total donation, as well as data on the different types of ADRs. The Chi-square test was used to analyze risk factors for Vasovagal reactions (VVRs) and inter-group comparisons of VVRs stratified by age (18\u201322; 23\u201329; 30\u201339; 40\u201349; 50\u201360), gender (female\/male), donation history (first time\/repeat), and blood donation volume (200\u202fmL\/300\u202fmL\/400\u202fmL), type of collection site (fixed site\/blood collection shelter\/blood collection vehicle\/others) and donor source (individual\/social group\/high school). Lastly, risk factors for blood donation-related syncope were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 2020 and 2022, 32,523 cases of ADRs were reported, among which VVRs accounted for 96.8% of all reactions. The overall reported incidence of ADRs was 12.577%. Notably, the incidence of VVRs decreased with increasing donor age. Additionally, the estimated incidences of VVRs were higher among female donors (13.600%) and first-time donors (18.536%) compared to male donors (11.205%) or repeat donors (5.819%). Moreover, 1,120 VVRs with syncope were recorded, accounting for 3.56% of total VVR cases. Finally, donors from outdoor blood collection sites (0.590%) and groups (1.073%) were at a significantly higher risk of syncope compared to those from indoor blood donation sites (0.438%) and individual donors (0.174%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The reported incidence rate of ADRs related to blood donation was very low. The higher prevalence of VVR and syncope in young, females, first-time donors, college students, and donating in mobile vehicles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1567370","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:35:28Z","timestamp":1764138928000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Profile and risk factors of blood donors who experienced adverse reactions: a cross-sectional study on donor hemovigilance data reported to the national network from 2020 to 2022 in China"],"prefix":"10.3389","volume":"13","author":[{"given":"Junhong","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/trf.15854","article-title":"Donor hemovigilance: a call to arms","volume":"60","author":"Storch","year":"2020","journal-title":"Transfusion"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.tracli.2024.03.001","article-title":"How we forecast tomorrow\u2019s haemovigilance","volume":"31","author":"Wood","year":"2024","journal-title":"Transfus Clin Biol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.biologicals.2011.12.003","article-title":"Donor vigilance: what are we doing about it?","volume":"40","author":"Wiersum-Osselton","year":"2012","journal-title":"Biologicals"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/vox.12323","article-title":"Development of standard definitions for surveillance of complications related to blood donation","volume":"110","author":"Goldman","year":"2016","journal-title":"Vox 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Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/vox.13048","article-title":"Complications of blood donation reported to haemovigilance systems: analysis of eleven years of international surveillance","volume":"116","author":"Wiersum-Osselton","year":"2021","journal-title":"Vox Sang"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"376","DOI":"10.13303\/j.cjbt.issn.1004-549x.2021.04.013","article-title":"Incidence of adverse reactions to whole blood donation in China: a meta-analysis","volume":"34","author":"Yang","year":"2021","journal-title":"Chin J Blood Transfus"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/vox.13421","article-title":"First donor haemovigilance system at a national level in China: establishment and improvement","volume":"118","author":"Yang","year":"2023","journal-title":"Vox Sang"},{"key":"ref11","year":""},{"key":"ref12","year":""},{"key":"ref13","volume-title":"R: a language and environment for statistical computing","year":"2022"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2450\/2021.0114-21","article-title":"Vasovagal reactions in whole blood and apheresis donors: a cross-sectional study on donor haemovigilance data from 2016 to 2019 in Italy","volume":"20","author":"Piccinini","year":"2022","journal-title":"Blood Transfus"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/vox.12447","article-title":"The international haemovigilance network database for the surveillance of adverse reactions and events in donors and recipients of blood components: technical issues and results","volume":"111","author":"Politis","year":"2016","journal-title":"Vox Sang"},{"key":"ref16","year":""},{"key":"ref17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.13303\/j.cjbt.issn.1004-549x.2024.02.017","article-title":"Reported incidence of adverse reactions in plateletapheresis donors in China: a 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(2018)","volume":"48","author":"Orru\u2019","year":"2021","journal-title":"Transfus Med Hemother"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/trf.15065","article-title":"Can we prevent vasovagal reactions in young inexperienced whole blood donors? A placebo controlled study comparing effects of a 330 vs 500 mL water drink prior to donation","volume":"59","author":"Wiersum-Osselton","year":"2019","journal-title":"Transfusion"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/vox.13579","article-title":"Development and validation of a scoring system to predict vasovagal reaction upon whole-blood donation","volume":"119","author":"Hashizume","year":"2024","journal-title":"Vox Sang"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/trf.16099","article-title":"Donation related fears predict vasovagal reactions and donor attrition among high school donors","volume":"61","author":"France","year":"2021","journal-title":"Transfusion"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1111\/trf.17759","article-title":"Donor complication rates in whole blood, plasma and platelet donors: age versus experience","volume":"64","author":"Paalvast","year":"2024","journal-title":"Transfusion"},{"key":"ref26","year":""},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1111\/trf.13716","article-title":"Prevention of syncopal-type reactions after whole blood donation: a cluster-randomized trial assessing hydration and muscle tension exercise","volume":"56","author":"Morand","year":"2016","journal-title":"Transfusion"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1037\/hea0000053","article-title":"Social contagion of vasovagal reactions in the blood collection clinic: a possible example of mass psychogenic illness","volume":"33","author":"Ditto","year":"2014","journal-title":"Health Psychol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1111\/trf.16333","article-title":"Frequency of rare, serious donor reactions: international perspective","volume":"61","author":"Young","year":"2021","journal-title":"Transfusion"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1567370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:35:31Z","timestamp":1764138931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1567370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":29,"alternative-id":["10.3389\/fpubh.2025.1567370"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1567370","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"article-number":"1567370"}}