{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:44:27Z","timestamp":1784810667685,"version":"3.55.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anomalies in basal metabolic rate (BMR) among middle-aged and older populations can lead to various metabolism-related diseases, presenting a significant global public health challenge. The association and mechanism between sleep duration and BMR remain unclear. This study aimed to investigate the mediating role of handgrip strength in the relationship between sleep duration and BMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study utilized data from the 2015 China Health and Retirement Longitudinal Study (CHARLS), comprising 10,161 participants aged 45 and older. The mediating effect of handgrip strength on the relationship between sleep duration and BMR was analyzed using linear regression model and bootstrap method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After controlling for confounding variables, a positive correlation was observed between sleep duration and BMR, with standardized regression coefficients (<jats:italic>\u03b2<\/jats:italic>) of 1.65, 95% confidence interval (CI) ranging from 0.63 to 2.70, and a significance level of <jats:italic>p<\/jats:italic>\u202f=\u202f0.002. Grip strength was positively correlated with BMR, <jats:italic>\u03b2<\/jats:italic> was 4.63, 95% CI: 4.34 to 5.91, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001. Handgrip strength mediates 22.42% of the total effect linking sleep duration to BMR. The mediating effect was 0.37, 95% CI: 0.07\u20130.67.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study identified significant positive correlations between sleep duration and BMR, as well as handgrip strength and BMR, with handgrip strength mediating the relationship between sleep duration and BMR.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1567396","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:25:44Z","timestamp":1752729944000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The mediating effect of handgrip strength on the association between sleep duration and basal metabolic rate in middle-aged and older adults: evidence from the China health and retirement longitudinal study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xinxiang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e462","DOI":"10.1016\/S2468-2667(19)30162-8","article-title":"Projections up to 2100 and a budget optimisation strategy towards cervical cancer elimination in China: a modelling study","volume":"4","author":"Xia","year":"2019","journal-title":"Lancet Public Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1086\/698372","article-title":"On the interplay among ambient temperature, basal metabolic rate, and body mass","volume":"192","author":"Naya","year":"2018","journal-title":"Am Nat"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3945\/ajcn.111.029975","article-title":"Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite","volume":"97","author":"Caudwell","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1111\/jdv.13522","article-title":"Body composition and basal metabolic rate in hidradenitis Suppurativa: a Danish population-based and hospital-based cross-sectional study","volume":"30","author":"Miller","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2337\/db22-0610","article-title":"Causal associations between basal metabolic rate and COVID-19","volume":"72","author":"Baranova","year":"2023","journal-title":"Diabetes"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"959","DOI":"10.3945\/ajcn.116.134965","article-title":"Does basal metabolic rate predict weight gain?","volume":"104","author":"Anthanont","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/ijc.32753","article-title":"Predicted basal metabolic rate and cancer risk in the European prospective investigation into Cancer and nutrition","volume":"147","author":"Kliemann","year":"2020","journal-title":"Int J Cancer"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/483158d","article-title":"Sugar: an excess of anything can harm","volume":"483","author":"Cottrell","year":"2012","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1126\/science.332.6033.1032-b","article-title":"CT risks dwarfed by diagnostic benefits","volume":"332","author":"Bodenstein","year":"2011","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1080\/15265161.2018.1445315","article-title":"Rejecting reality and substituting one?'s own; 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