{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T12:01:59Z","timestamp":1781956919162,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"Introduction<\/jats:title>The older population is growing fast, and it is important to investigate the cardiovascular health factors and behaviors that are associated with cardiovascular disease (CVD) and mortality among older individuals.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 920 older adults (mean age: 74\u202fyears, 55% women) from the InCHIANTI study were included for analysis. Cardiovascular health (CVH) was assessed using the Life\u2019s Essential 8 (LE8) developed by the American Heart Association, including 8 health behaviors (smoking, diet, physical activity, sleep) and factors (body mass index, blood cholesterol, blood glucose, blood pressure). The LE8 score ranges from 0 to 100, with higher score indicating better CVH. CVH was analyzed on both a continuous scale [per 1 standard deviation (SD) increase] and categorical scale [low (CVH) score &lt; 50 vs. moderate\/high (CVH) score \u2265 50]. Cox hazard models were used to calculate the hazard ratios (HRs) of CVD and all-cause mortality associated with CVH and its components adjusting for age, sex, study site, education, presence of ADL and IADL limitations, cognitive impairment, depression, and presence of chronic disease.<\/jats:p><\/jats:sec>Results<\/jats:title>The median follow-up time was 14.5\u202fyears. Participants with moderate\/high CVH had better survival rates for both CVD and all-cause mortality compared to those with low CVH. One SD increase in LE8 score was associated with 28% (p<\/jats:italic>\u202f=\u202f0.001) and 17% (p<\/jats:italic>\u202f&lt;\u202f0.001) lower risk of CVD and all-cause mortality, respectively.<\/jats:p><\/jats:sec>Discussion<\/jats:title>Among older community dwelling men and women, better CVH is inversely associated with CVD and all-cause mortality, and this lends credence to the importance of prioritizing health factors and behaviors in preventing chronic disease and promoting healthier lives among older adults.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1570463","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:44:49Z","timestamp":1748583889000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiovascular health assessed using Life\u2019s Essential 8 is associated with all-cause and cardiovascular disease mortality among community-dwelling older men and women in the InCHIANTI study"],"prefix":"10.3389","volume":"13","author":[{"given":"Vivek","family":"Sarma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bandinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameera A.","family":"Talegawkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"ref1","volume-title":"The next four decades: The older population in the United States: 2010 to 2050","author":"Vincent","year":"2010"},{"key":"ref2","volume-title":"Global health and ageing (NIH Publication No. 11-7737)","year":"2011"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"107184","DOI":"10.1016\/j.vascn.2022.107184","article-title":"On the perspective of an aging population and its potential impact on drug attrition and pre-clinical cardiovascular safety assessment","volume":"117","author":"Fermini","year":"2022","journal-title":"J Pharmacol Toxicol Methods"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e12861","DOI":"10.1111\/acel.12861","article-title":"Trends in age-related disease burden and healthcare utilization","volume":"18","author":"Atella","year":"2019","journal-title":"Aging Cell"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0140-6736(89)90828-3","article-title":"Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART)","volume":"334","author":"Burr","year":"1989","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-319-23847-0_5","article-title":"Chronic disease prevention and health promotion","volume-title":"Public health ethics: cases spanning the globe","author":"Schmidt","year":"2016"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1001\/jama.1993.03500040049035","article-title":"Body fat distribution and 5-year risk of death in older women","volume":"269","author":"Folsom","year":"1993","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1136\/bjsports-2014-094522","article-title":"Increases in physical activity is as important as smoking cessation for reduction in total mortality in elderly men: 12 years of follow-up of the Oslo II study","volume":"49","author":"Holme","year":"2015","journal-title":"Br J Sports Med"},{"key":"ref9","first-page":"3","article-title":"CDC National Health Report: leading causes of morbidity and mortality and associated behavioral risk and protective factors--United States, 2005-2013","volume":"63","author":"Johnson","year":"2014","journal-title":"MMWR Suppl"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/00004872-198712000-00019","article-title":"Blood pressure and mortality in old age. 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