{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:12:57Z","timestamp":1761005577207,"version":"build-2065373602"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019 (COVID-19) remains a major global health challenge, mostly affecting developing countries such as Ethiopia, which is facing low COVID-19 vaccination acceptance. This study aimed to assess the uptake of the COVID-19 vaccine and its associated factors among high school students in Lemi Kura Sub-City, Addis Ababa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An institution-based cross-sectional study was conducted at public high schools. Self-administered questionnaires were used to collect data from randomly selected high school students. We used Epi Info and SPSS for data entry and analysis. Descriptive and multivariable logistic regression analyses were performed to identify factors associated with COVID-19 vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 802 participants (95% response rate), 46.2% were vaccinated. A total of 445 students (55.5%) had a positive attitude toward the COVID-19 vaccine, and 319 students (39.8%) had good knowledge about it. In addition, 625 students (78%) had undergone COVID-19 testing, and 286 students (35.7%) reported a history of infection. Factors significantly associated with vaccine uptake were good knowledge (AOR\u202f=\u202f2.1, 95%CI: 1.4\u20133.1), positive attitude (AOR\u202f=\u202f14.4, 95%CI: 9.5\u201322), prior testing (AOR\u202f=\u202f2.1, 95%CI: 1.2\u20133.7), and absence of exposure to negative information (AOR\u202f=\u202f2.26, 95%CI: 1.3\u20133.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall COVID-19 vaccine uptake was low. Knowledge, attitude, prior COVID-19 testing, and exposure to misinformation significantly influenced vaccine uptake among high school students. Improving awareness among the target population is essential to enhancing vaccination rates.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1571217","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:23:14Z","timestamp":1760937794000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 vaccine uptake and associated factors among high school students in Lemi Kura Sub-City, Addis Ababa, 2022"],"prefix":"10.3389","volume":"13","author":[{"given":"Etana","family":"Busa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jemal","family":"Beksisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinabu","family":"Reda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisay Abebe","family":"Debela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref1","volume-title":"Coronavirus disease 2019 (COVID-19) situation report","year":"2021"},{"key":"ref2","volume-title":"COVID-19 weekly epidemiological update - edition 116","year":"2022"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e1099","DOI":"10.1016\/S2214-109X(22)00233-9","article-title":"COVID-19 in the 47 countries of the WHO African region: a modelling analysis of past trends and future patterns","volume":"10","author":"Cabore","year":"2022","journal-title":"Lancet Glob Heal"},{"key":"ref4","unstructured":"COVID-19 weekly epidemiological update\n          \n          \n          Geneva\n          WHO\n          \n          2022"},{"key":"ref5","year":"2022"},{"key":"ref6","volume-title":"Who Sage roadmap for prioritizing uses of Covid 19 vaccines in the context of limited supply","year":"2020"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/1468-0009.12503","article-title":"International collaboration to ensure equitable access to vaccines for COVID-19: the ACT-accelerator and the COVAX facility","volume":"99","author":"Eccleston-Turner","year":"2021","journal-title":"Milbank Q"},{"key":"ref8","volume-title":"Status of COVID-19 vaccines within WHO EUL \/ PQ evaluation process","year":"2021"},{"key":"ref9","author":"Scarpetta","year":"2021"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/vaccines9080905","article-title":"Disparities in covid-19 vaccination among low-, middle-, and high-income countries: the mediating role of vaccination policy","volume":"9","author":"Duan","year":"2021","journal-title":"Vaccine"},{"key":"ref11","volume-title":"Covid19 management handbook","year":"2020"},{"key":"ref12","volume-title":"Updated stakeholder engagement plan (SEP) Ethiopia COVID-19 emergency response project July 2020","year":"2020"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/2313367","article-title":"COVID-19 vaccine acceptance level in Ethiopia: a systematic review and Meta-analysis","volume":"2022","author":"Sahile","year":"2022","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0263081","article-title":"COVID-19 vaccine hesitancy among medical and health science students attending Wolkite university in Ethiopia","volume":"17","author":"Mose","year":"2022","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.2147\/IDR.S320771","article-title":"Covid-19 vaccination acceptance and its associated factors in Sodo town, wolaita zone, southern Ethiopia: cross-sectional study","volume":"14","author":"Mesele","year":"2021","journal-title":"Infect Drug Resist"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40545-021-00397-6","article-title":"COVID-19 vaccines: awareness, attitude and acceptance among undergraduate university students","volume":"15","author":"Asres","year":"","journal-title":"J Pharm Policy Pract"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"35909","DOI":"10.11604\/pamj-oh.2022.8.14.35909","article-title":"COVID-19 vaccine uptake and its determinants among residents of South Gondar zone, Northwest Ethiopia: a cross-sectional study","volume":"8","author":"Dagnew","year":"2022","journal-title":"PAMJ One Heal"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.2147\/JMDH.S381151","article-title":"COVID-19 vaccine acceptance and associated factors among college students in Dessie City, northeastern Ethiopia","volume":"15","author":"Berihun","year":"2022","journal-title":"J Multidiscip Healthc"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e0269273","DOI":"10.1371\/journal.pone.0269273","article-title":"Determinants of COVID-19 vaccine acceptance in Ethiopia: a systematic review and meta-analysis","volume":"17","author":"Mose","year":"2022","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/vaccines9010042","article-title":"High rates of COVID-19 vaccine hesitancy and its association with conspiracy beliefs: a study in jordan and kuwait among other Arab Countries","volume":"9","author":"Sallam","year":"2021","journal-title":"Vaccines"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4280","DOI":"10.1002\/jmv.26910","article-title":"Vaccine hesitancy: beliefs and barriers associated with COVID-19 vaccination among Egyptian medical students","volume":"93","author":"Saied","year":"2021","journal-title":"J Med Virol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1177\/22799036221103108","article-title":"COVID-19 vaccination perceptions and attitudes among Egyptian medical students","volume":"11","author":"Abdel-Aziz","year":"2022","journal-title":"J Public Health Res"},{"key":"ref23","year":"2014"},{"key":"ref24","first-page":"466","article-title":"Slow progression: educational trajectories of young men and women in Ethiopia","volume":"24","author":"Tafere","year":"2021","journal-title":"J Youth Stud"},{"key":"ref25","volume-title":"Population Projections for Ethiopia 2007\u20132037","year":"2014"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1186\/s40068-024-00359-2","article-title":"Land use transformation by urban informal settlements and ecosystem impact","volume":"13","author":"Hailu","year":"2024","journal-title":"Environ Syst Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.dsx.2021.04.004","article-title":"Development and validation of a questionnaire to assess knowledge, attitude, practices, and concerns regarding COVID-19 vaccination among the general population","volume":"15","author":"Kumari","year":"2021","journal-title":"Diabetes Metab Syndr"},{"key":"ref28","volume-title":"Community needs, perceptions and demand: community assessment tool","year":"2021"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"560","DOI":"10.4103\/ijcm.IJCM_16_20","article-title":"Errors in the use of multivariable logistic regression analysis: an empirical analysis","volume":"45","author":"Kluwer","year":"2020","journal-title":"Indian J Community Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/rssb.12122","article-title":"Sequential selection procedures and false discovery rate control","volume":"78","author":"G\u2019Sell","year":"2016","journal-title":"J R Stat Soc Ser B Stat Methodol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2352-4642(18)30022-1","article-title":"The age of adolescence","volume":"2","author":"Sawyer","year":"2018","journal-title":"Lancet Child Adolesc Heal"},{"key":"ref32","first-page":"1","article-title":"Global adolescent health: investing in the triple dividend","author":"Sawyer","year":"2018"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"105010","DOI":"10.1016\/j.nedt.2021.105010","article-title":"Factors influencing nursing students\u2019 intention to accept COVID-19 vaccination: a pooled analysis of seven European countries","volume":"104","author":"Patelarou","year":"2021","journal-title":"Nurse Educ Today"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e0266670","DOI":"10.1371\/journal.pone.0266670","article-title":"COVID-19 vaccine acceptance, hesitancy, and associated factors among medical students in Sudan","volume":"17","author":"Raja","year":"2022","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"303","DOI":"10.18203\/2394-6040.ijcmph20215014","article-title":"Knowledge, attitude and practice towards COVID-19 vaccination acceptance in West India","volume":"9","author":"Bhartiya","year":"2021","journal-title":"Int J Community Med Public Health"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41182-021-00331-1","article-title":"Ong medical students in UgaAease-2019 vaccine AMNDA","volume":"49","author":"Olum","year":"2021","journal-title":"Trop Med Health"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/pubmed\/fdaa230","article-title":"COVID-19 vaccine hesitancy among medical students","volume":"43","author":"Lucia","year":"2021","journal-title":"J Public Health"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2147\/POR.S271096","article-title":"Acceptability of vaccination against COVID-19 among healthcare workers in the Democratic Republic of the Congo","volume":"11","author":"Nzaji","year":"2020","journal-title":"Pragmat Obs Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41562-021-01056-1","article-title":"Measuring the impact of COVID-19 vaccine misinformation on vaccination intent in the UK and USA","volume":"5","author":"Loomba","year":"2021","journal-title":"Nat Hum Behav"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2024\/9947720","article-title":"Misinformation on COVID-19 vaccine and its associated factors among residents in Gondar, Ethiopia, 2022","volume":"2024","author":"Jember","year":"2024","journal-title":"Biomed Res Int"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1056\/NEJMra2106441","article-title":"The vaccine-hesitant moment","volume":"387","author":"Larson","year":"2022","journal-title":"N Engl J Med"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1571217\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:23:17Z","timestamp":1760937797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1571217\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":41,"alternative-id":["10.3389\/fpubh.2025.1571217"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1571217","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"article-number":"1571217"}}