{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:33:46Z","timestamp":1782758026696,"version":"3.54.5"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Our study aimed to clarify the impact of home quarantine on disease severity, quality of life, and mental health in psoriasis patients through the multidimensional analysis of the status of home quarantine, the severity of psoriasis, quality of life, and depression scores during the COVID-19 pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2022 to 2023, we conducted telephone follow-up on 963 psoriasis patients. Participants\u2019 demographic characteristics, psoriasis condition, home quarantine duration, quality of life and depression symptom scores were collected. The association between COVID-19 lockdown and patient-reported outcomes were investigated with pearson correlation and Spearman correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 963 participants were recruited, finally 605 participants were enrolled. The mean values of age and disease duration was 43.63\u202fyears, 312.35\u202fyears, 67.6% were male. Patients with disease-related impaired quality of life (DLQI &amp;gt; 5) accounted for 7.44%. A total of 65 patients had varying degrees of depression symptoms (QIDS-SR16\u202f&amp;gt;\u202f5 points). The result of correlation analysis revealed a positive correlation between BSA and both DLQI and QIDS-SR16 scores (R\u202f=\u202f0.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001; R\u202f=\u202f0.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results revealed that COVID-19 lockdown had a measurable impact on disease severity, quality of life, and mental health in psoriasis patients. Many individuals experienced varying degrees of symptoms aggravation during the lockdown. The severity of psoriasis was negatively correlated with quality of life and positively correlated with depression symptoms, with older adult patients being particularly vulnerable to depression. These findings highlight the importance for dermatologists to integrate mental health assessment and support into routine psoriasis management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1603623","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:18:04Z","timestamp":1761106684000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The association between COVID-19 lockdown and disease severity, quality of life, and mental health in patients with psoriasis: a cross-sectional study in Southwestern China"],"prefix":"10.3389","volume":"13","author":[{"given":"Xinyi","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"743180","DOI":"10.3389\/fmed.2021.743180","article-title":"The global, regional, and national burden of psoriasis: results and insights from the global burden of disease 2019 study","volume":"8","author":"Damiani","year":"2021","journal-title":"Front Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jaad.2008.10.062","article-title":"Trends in incidence of adult-onset psoriasis over three decades: a population-based study","volume":"60","author":"Icen","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1186455","DOI":"10.3389\/fimmu.2023.1186455","article-title":"Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies","volume":"14","author":"Brembilla","year":"2023","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1038\/jid.2013.508","article-title":"The prevalence and odds of depressive symptoms and clinical depression in psoriasis patients: a systematic review and meta-analysis","volume":"134","author":"Dowlatshahi","year":"2014","journal-title":"J Invest Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/jdv.13891","article-title":"The prevalence of anxiety in patients with psoriasis: a systematic review of observational studies and clinical trials","volume":"31","author":"Fleming","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"552764","DOI":"10.3389\/fpsyg.2020.552764","article-title":"Positive psychological factors are associated with better spiritual well-being and lower distress in individuals with skin diseases","volume":"11","author":"Iani","year":"2020","journal-title":"Front Psychol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.comppsych.2016.08.001","article-title":"Health-related quality of life and its association with alexithymia and difficulties in emotion regulation in patients with psoriasis","volume":"70","author":"Innamorati","year":"2016","journal-title":"Compr Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jpsychores.2017.12.011","article-title":"Cognitive impairment in patients with psoriasis: a matched case-control study","volume":"105","author":"Innamorati","year":"2018","journal-title":"J Psychosom Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/13651501.2017.1301482","article-title":"Psychiatric comorbidity and suicidal ideation in psoriasis, melanoma and allergic disorders","volume":"21","author":"Pompili","year":"2017","journal-title":"Int J Psychiatry Clin Pract"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.jiph.2021.05.020","article-title":"COVID-19: a new challenge for mental health and policymaking recommendations","volume":"14","author":"Alshammari","year":"2021","journal-title":"J Infect Public Health"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12985-021-01729-3","article-title":"Mental health status of COVID-19 survivors: a cross sectional study","volume":"19","author":"Jafri","year":"2022","journal-title":"Virol J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/ijerph19010161","article-title":"Mental health in the time of COVID-19 pandemic: a worldwide perspective","volume":"19","author":"Sampogna","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"ref14","first-page":"64","article-title":"Dermatology life quality index in patients of psoriasis and its correlation with severity of disease","volume":"32","author":"Khan","year":"2020","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e20200378","DOI":"10.47626\/2237-6089-2020-0378","article-title":"Validation of the Brazilian Portuguese version of the quick inventory of depressive symptomatology and self-report (QIDS-SR16) for the Brazilian population","volume":"45","author":"Bandinelli","year":"2023","journal-title":"Trends Psychiatry Psychother"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fpsyg.2016.00087","article-title":"Getting under the skin: report from the international psoriasis council workshop on the role of stress in psoriasis","volume":"7","author":"Schwartz","year":"2016","journal-title":"Front Psychol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"409637","DOI":"10.1155\/2015\/409637","article-title":"Exploring the physiological link between psoriasis and mood disorders","volume":"2015","author":"Connor","year":"2015","journal-title":"Dermatol Res Pract"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"403908","DOI":"10.1155\/2012\/403908","article-title":"Psychological stress and the cutaneous immune response: roles of the HPA Axis and the sympathetic nervous system in atopic dermatitis and psoriasis","volume":"2012","author":"Hall","year":"2012","journal-title":"Dermatol Res Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1007\/s00127-022-02303-0","article-title":"Mental health and COVID-19 in a general population cohort in Spain (COVICAT study)","volume":"57","author":"Goldberg","year":"2022","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1111\/ced.14330","article-title":"Mental health and dermatology practice in the COVID-19 pandemic","volume":"45","author":"Lada","year":"2020","journal-title":"Clin Exp Dermatol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3390\/dermatopathology9030027","article-title":"The impact of COVID-19 pandemic on dermatological conditions: a novel, comprehensive review","volume":"9","author":"Pendlebury","year":"2022","journal-title":"Dermatopathology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"625","DOI":"10.4103\/idoj.idoj_46_22","article-title":"Effect of lockdown due to COVID-19 on health and lifestyle of psoriasis patients: a web-based survey","volume":"13","author":"Narang","year":"2022","journal-title":"Indian Dermatol Online J"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1027853","DOI":"10.3389\/fmed.2022.1027853","article-title":"Factors associated with worsened clinical symptoms of psoriasis and disease-related quality of life during the COVID-19 lockdown: a cross-sectional study","volume":"9","author":"Burkauskas","year":"2022","journal-title":"Front Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.1038\/s41598-024-54424-y","article-title":"Prevalence, outcomes and associated factors of SARS-CoV-2 infection in psoriasis patients of Southwest China: a cross-sectional survey","volume":"14","author":"Zou","year":"2024","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e0275293","DOI":"10.1371\/journal.pone.0275293","article-title":"Paradoxical improvement of life quality in the COVID-19 era in psoriasis patients","volume":"17","author":"Boch","year":"2022","journal-title":"PLoS One"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1603623\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:18:05Z","timestamp":1761106685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1603623\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":25,"alternative-id":["10.3389\/fpubh.2025.1603623"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1603623","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"article-number":"1603623"}}