{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:51:17Z","timestamp":1789055477636,"version":"build-2803163510"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amidst global demographic aging patterns, understanding divergent trajectories of pancreatitis burden is crucial for health equity. This study compares China\u2019s pancreatitis burden (1990\u20132021) against global aggregates, focusing on age-sex stratification within aging populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Leveraging Global Burden of Disease 2021 datasets, we analyzed age-standardized rates (ASR) for incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs\/ASDR). Joinpoint regression quantified temporal trends via average annual percentage changes (AAPC). Statistical significance was determined through 95% confidence intervals (CIs). GBD standardization protocols ensured comparability of sex-age stratified analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 1990 to 2021, China witnessed significant declines in pancreatitis burden. The age-standardized rates per 100,000 population fell as follows: incidence (ASIR) from 35.35 to 23.95; prevalence (ASPR) from 35.33 to 24.15; mortality (ASMR) from 0.98 to 0.64; and DALYs (ASDR) from 29.77 to 18.27. The corresponding average annual percentage changes (AAPCs: ASIR \u22121.34%; ASPR \u22121.25%; ASMR \u22121.40%; ASDR \u22121.57%) were substantially greater than the global averages (ASIR \u22120.44%; ASPR \u22120.99%; ASMR \u22120.47%; ASDR \u22120.53%). Age and sex disparities were clear, with males having higher rates below age 65, and females bearing a greater burden thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights a marked decline in China\u2019s pancreatitis burden, linked to healthcare advances, despite persistent disparities in older populations. Moving beyond isolated descriptions of trends, our study introduces a direct comparative analysis that quantifies China\u2019s steeper decline in pancreatitis burden relative to the global average. This provides a nuanced, quantitative benchmark for evaluating the effectiveness of national health policies. These findings call for equitable policies and future work on region-specific risks and scalable interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1616215","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T05:13:39Z","timestamp":1764911619000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative analysis of trends in the burden of pancreatitis in China and worldwide, 1990\u20132021"],"prefix":"10.3389","volume":"13","author":[{"given":"Jianwang","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","article-title":"Burden 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