{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:13:03Z","timestamp":1793020383609,"version":"4.5.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Studies examining associations between meteorological factors and outpatient visits for chronic rhinosinusitis (CRS) are limited. This study aimed to investigate the effects of daily mean temperature, relative humidity (RH) and precipitation on outpatient visits for CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic records of CRS outpatient visits were collected from Tongji hospital in Wuhan, China from January 1, 2018 to December 31, 2019. Daily meteorological data were obtained from the Wuhan Meteorological Bureau during the same period. A generalized additive negative binomial regression model combined with a distributed lag non-linear model (DLNM) was employed to analyze the lag-exposure-response relationship between meteorological factors and the number of CRS outpatient visits. Stratified analyses were conducted to identify potential effect modifications by age and season.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14,259 CRS outpatient visits were recorded. Relative humidity and precipitation showed no significant association with daily CRS visits, whereas low temperatures significantly elevated CRS outpatient visits. Specifically, extreme temperature (\u22121.8\u00b0C, 1st percentile) was found to be associated with 1.946 (95% CI 1.273\u20132.973) times the risk of outpatient visits due to CRS, compared to the reference value of 32.9\u00b0C. Furthermore, the number of outpatient visits for childhood and younger individuals with CRS showed a negative correlation with temperatures, whereas middle-aged individuals and older adult individuals showed no such correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that meteorological phenomena may have detrimental effects on health, thereby contributing to a better understanding of the environmental risk factors associated with this disease.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1621856","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:31:53Z","timestamp":1751002313000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of meteorological factors on outpatient visits for chronic rhinosinusitis in Wuhan, China (2018\u20132019): a time-series analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoli","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/j.jaci.2022.02.016","article-title":"Mechanisms and pathogenesis of chronic rhinosinusitis","volume":"149","author":"Kato","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/alr.22741","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis 2021","volume":"11","author":"Orlandi","year":"2021","journal-title":"Int Forum Allergy Rhinol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1177\/1945892420982236","article-title":"Clinical and biological markers predict the efficacy of glucocorticoid- and macrolide-based postoperative therapy in patients with chronic Rhinosinusitis","volume":"35","author":"Zeng","year":"2021","journal-title":"Am J Rhinol Allergy"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study","volume":"66","author":"Hastan","year":"2011","journal-title":"Allergy"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"173526","DOI":"10.1016\/j.scitotenv.2024.173526","article-title":"Air pollution, genetic factors, and chronic rhinosinusitis: a prospective study in the UK biobank","volume":"940","author":"Zhou","year":"2024","journal-title":"Sci Total Environ"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/lio2.774","article-title":"Environmental air pollution and chronic rhinosinusitis: a systematic review","volume":"7","author":"Leland","year":"2022","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.jaci.2019.11.040","article-title":"Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts","volume":"145","author":"Burte","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"294","DOI":"10.21053\/ceo.2018.00612","article-title":"The effects of air pollutants on the prevalence of common ear, nose, and throat diseases in South Korea: a National Population-Based Study","volume":"12","author":"Park","year":"2019","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"110923","DOI":"10.1016\/j.ecoenv.2020.110923","article-title":"Acute effect of ambient air pollution on hospital outpatient cases of chronic sinusitis in Xinxiang, China","volume":"202","author":"Lu","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/alr.23128","article-title":"Climate change, the environment, and rhinologic disease","volume":"13","author":"Kim","year":"2023","journal-title":"Int Forum Allergy Rhinol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"451","DOI":"10.4193\/Rhin21.141","article-title":"Association between air pollution and chronic rhinosinusitis: a nested case-control study using meteorological data and national health screening cohort data","volume":"59","author":"Wee","year":"2021","journal-title":"Rhinology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1177\/19458924211069226","article-title":"The impact of climatic, socioeconomic, and geographic factors on the prevalence of allergic fungal Rhinosinusitis: a worldwide ecological study","volume":"36","author":"AlQahtani","year":"2022","journal-title":"Am J Rhinol Allergy"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1002\/alr.23152","article-title":"Association between ambient temperature and chronic rhinosinusitis","volume":"13","author":"Du","year":"2023","journal-title":"Int Forum Allergy Rhinol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s00484-014-0899-0","article-title":"Temperature effects on outpatient visits of respiratory diseases, asthma, and chronic airway obstruction in Taiwan","volume":"59","author":"Wang","year":"2015","journal-title":"Int J Biometeorol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"464","DOI":"10.4193\/Rhin20.600","article-title":"European position paper on rhino sinusitis and nasal polyps 2020","volume":"58","author":"okkens","year":"2020","journal-title":"Rhinology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/bjd\/ljac124","article-title":"Effects of ambient air pollution on outpatient visits for psoriasis in Wuhan, China: a time-series analysis","volume":"188","author":"Lan","year":"2023","journal-title":"Br J Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Mortality GBD, causes of death C. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study 2013","volume":"385","year":"2015","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.scitotenv.2018.06.189","article-title":"A time-series study of the association of rainfall, relative humidity and ambient temperature with hospitalizations for rotavirus and norovirus infection among children in Hong Kong","volume":"643","author":"Wang","year":"2018","journal-title":"Sci Total Environ"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v043.i08","article-title":"Distributed lag linear and non-linear models in R: the package dlnm","volume":"43","author":"Gasparrini","year":"2011","journal-title":"J Stat Softw"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e6876","DOI":"10.7717\/peerj.6876","article-title":"Hierarchical generalized additive models in ecology: an introduction with mgcv","volume":"7","author":"Pedersen","year":"2019","journal-title":"PeerJ"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e0288101","DOI":"10.1371\/journal.pone.0288101","article-title":"Geo-climatic risk factors for chronic rhinosinusitis in Southwest Iran","volume":"18","author":"Ghatee","year":"2023","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s11882-020-00917-5","article-title":"Common cold and acute Rhinosinusitis: up-to-date management in 2020","volume":"20","author":"Jaume","year":"2020","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41390-023-02549-7","article-title":"Understanding COVID-19 in children: immune determinants and post-infection conditions","volume":"94","author":"Rotulo","year":"2023","journal-title":"Pediatr Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"l1878","DOI":"10.1136\/bmj.l1878","article-title":"Raising awareness of the health effects of environmental exposures","volume":"365","author":"Trakoli","year":"2019","journal-title":"BMJ"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1038\/s41591-023-02438-w","article-title":"Climate change and health: three grand challenges","volume":"29","author":"Campbell-Lendrum","year":"2023","journal-title":"Nat Med"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1621856\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:31:54Z","timestamp":1751002314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1621856\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":25,"alternative-id":["10.3389\/fpubh.2025.1621856"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1621856","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"article-number":"1621856"}}