{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:49:35Z","timestamp":1769575775565,"version":"3.49.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015997","name":"Brazilian Biodivesity Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p><jats:italic>Coxiella burnetii<\/jats:italic>, the causative agent of Q fever, a zoonotic pathogen with primarily airborne transmission and diverse host species, have been reported in serosurveys of vulnerable populations worldwide. Although vulnerable populations from oceanic islands and mainland seashore areas in Brazil may be also exposed <jats:italic>C. burnetti<\/jats:italic>, no study to date has concomitantly assessed owners and dogs in such environmental setting. Accordingly, the present study aimed to assess the <jats:italic>C. burnetii<\/jats:italic> seroprevalence in owners and their dogs from oceanic islands and mainland seashore areas of southern Brazil. Overall, 5\/335 (1.49%) humans and none\/352 (0%) dogs of three oceanic islands and two mainland coastal areas were seropositive to anti-<jats:italic>Coxiella burnetii<\/jats:italic> antibodies by Indirect Immunofluorescence Assays (IFA). Such low seroprevalence may have been consequence of the livestock absence of these environmentally preserved islands, in addition to a major geographical barrier to airborne dispersal in southern Brazilian seashore mainland areas due to the rainforest (Serra do Mar) mountains. Finally, absence of dog seropositivity herein, suggesting that seropositive humans were exposed to <jats:italic>C. burnetti<\/jats:italic> outside these islands and seashore mainland areas, may provide new insights of <jats:italic>C. burnetii<\/jats:italic> transmission, disease cycle and prevention.<\/jats:p>","DOI":"10.3389\/fpubh.2025.1643457","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:35:25Z","timestamp":1755063325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["One Health approach to Coxiella burnetii: first serosurvey of owners and dogs living on oceanic islands and mainland seashore areas of Brazil"],"prefix":"10.3389","volume":"13","author":[{"given":"Aaronson Ramathan","family":"Freitas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo Alves de","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise Bach","family":"Kmetiuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaella","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruana R.","family":"Delai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Turra","family":"Pimp\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Henrique","family":"Perotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Roque de Barros-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiano Borges","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vamilton Alvares","family":"Santar\u00e9m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helio","family":"Langoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Welker","family":"Biondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/CMR.00045-16","article-title":"From Q fever to Coxiella burnetii infection: a paradigm change","volume":"30","author":"Eldin","year":"2017","journal-title":"Clin Microbiol Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.idc.2008.03.002","article-title":"Q fever","volume":"22","author":"Tissot-Dupont","year":"2008","journal-title":"Infect Dis Clin North Am."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1466981","DOI":"10.3389\/fpubh.2024.1466981","article-title":"Coxiella burnetii (Q fever) exposure in wildlife professionals","volume":"12","author":"de Fran\u00e7a","year":"2024","journal-title":"Front Public Health."},{"key":"B4","doi-asserted-by":"publisher","first-page":"101032","DOI":"10.1016\/j.onehlt.2025.101032","article-title":"One health behind bars: seroincidence of Coxiella burnetii in women inmates, correctional officers, and feral cats","volume":"20","author":"de Fran\u00e7a","year":"2025","journal-title":"One Health."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10142","DOI":"10.1038\/s41598-024-60850-9","article-title":"One Health approach to Coxiella burnetii in Brazilian indigenous communities","volume":"14","author":"Farinhas","year":"2024","journal-title":"Sci Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/tropicalmed9040078","article-title":"Serosurvey of Coxiella burnetii in police officers and working dogs in Brazil: case report and One Health implications","volume":"9","author":"de Fran\u00e7a","year":"2024","journal-title":"Trop Med Infect Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/microorganisms12010092","article-title":"Serosurvey of Coxiella burnetii in descendants of former black slaves (Quilombola Communities) of Southern Brazil","volume":"12","author":"de Fran\u00e7a","year":"2024","journal-title":"Microorganisms."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0010392","DOI":"10.1371\/journal.pntd.0010392","article-title":"Seropositivity for Coxiella burnetii in suspected patients with dengue in S\u00e3o Paulo state, Brazil","volume":"16","author":"Fran\u00e7a","year":"2022","journal-title":"PLoS Negl Trop Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"101032","DOI":"10.1016\/j.onehlt.2025.101032","article-title":"One Health behind bars: seroincidence of Coxiella burnetii in woman inmates, correctional officers and feral cats","volume":"20","author":"Fran\u00e7a","year":"2025","journal-title":"One Health."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0004112","DOI":"10.1371\/journal.pntd.0004112","article-title":"Brucellosis and Coxiella burnetii infection in householders and their animals in secure villages in Herat Province, Afghanistan: a cross-sectional study","volume":"9","author":"Akbarian","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"key":"B11","unstructured":"Parque Estadual da Ilha do Mel (PEIM)"},{"key":"B12","unstructured":"Ilha do Mel e Parque do Monge est\u00e3o entre os atrativos mais visitados do Pa\n          \n          2024"},{"key":"B13","unstructured":"Uso e ocupa\u00e7\u00e3o do solo na Ilha do Mel\n          \n          2019"},{"key":"B14","unstructured":"IBGE | Cidades@ | Paran\u00e1 | Guaraque\u00e7aba | Panorama, (n.d.)"},{"key":"B15","unstructured":"IBGE | Cidades@ | Paran\u00e1 | Pontal do Paran\u00e1 | Panorama, (n.d.)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/trstmh\/trab113","article-title":"Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state","volume":"116","author":"Meurer","year":"2022","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"B17","unstructured":"Stevenson\n              M\n            \n            \n              Sergeant\n              E\n            \n            \n              Heuer\n              C\n            \n            \n              Nunes\n              T\n            \n            \n              Heuer\n              C\n            \n            \n              Marshall\n              J\n            \n          \n          epiR: Tools for the Analysis of Epidemiological Data\n          \n          2025"},{"key":"B18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4269\/ajtmh.2004.71.93","article-title":"Prevalence of antibodies to spotted fever group rickettsiae in humans and domestic animals in a Brazilian spotted fever-endemic area in the state of S\u00e3o Paulo, Brazil: serologic evidence for infection by Rickettsia rickettsii and another spotted fever group Rickettsia","volume":"71","author":"Horta","year":"2004","journal-title":"Am J Trop Med Hyg."},{"key":"B19","unstructured":"Pereira\n              RHM\n            \n            \n              Goncalves\n              CN\n            \n          \n          geobr: Download Official Spatial Data Sets of Brazil\n          \n          2024"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1201\/9780429459016","author":"Pebesma","year":"2023","journal-title":"Spatial Data science: With Applications in R"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2300688","DOI":"10.2807\/1560-7917.ES.2024.29.27.2300688","article-title":"Epidemiology of Q fever in humans in four selected regions, Spain, 2016 to 2022","volume":"29","author":"Cifo","year":"2024","journal-title":"Euro Surveill."},{"key":"B22","doi-asserted-by":"publisher","first-page":"ofz227","DOI":"10.1093\/ofid\/ofz227","article-title":"Seroprevalence of Coxiella burnetii (Q fever) exposure in humans on reunion island","volume":"6","author":"Jaubert","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1128\/JCM.36.7.2063-2067.1998","article-title":"Q Fever in the Greek Island of crete: detection, isolation, and molecular identification of eight strains of Coxiella burnetii from clinical samples","volume":"36","author":"Spyridaki","year":"1998","journal-title":"J Clin Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"100485","DOI":"10.1016\/j.onehlt.2023.100485","article-title":"Is there a higher risk of exposure to Coxiella burnetii for pre-clinical veterinary students?","volume":"16","author":"Conan","year":"2023","journal-title":"One Health."},{"key":"B25","doi-asserted-by":"publisher","first-page":"101132","DOI":"10.1016\/j.vprsr.2024.101132","article-title":"Molecular screening of selected vector-borne pathogens circulating in owned dogs in the Caribbean archipelago of Guadeloupe (France)","volume":"56","author":"Imbert","year":"2024","journal-title":"Vet Parasitol: Reg Stud Reports."},{"key":"B26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1023\/A:1007400327007","article-title":"Occupational risks of zoonotic infections in Dutch forestry workers and muskrat catchers","volume":"14","author":"Moll van Charante","year":"1998","journal-title":"Eur J Epidemiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"100197","DOI":"10.1016\/j.onehlt.2020.100197","article-title":"Coxiella burnetii seroprevalence and Q fever in Australian wildlife rehabilitators","volume":"12","author":"Mathews","year":"2021","journal-title":"One Health."},{"key":"B28","doi-asserted-by":"publisher","first-page":"767","DOI":"10.5604\/12321966.1129930","article-title":"Prevalence of antibodies against selected zoonotic agents in forestry workers from eastern and southern Poland","volume":"21","author":"\u017bukiewicz-Sobczak","year":"2014","journal-title":"Ann Agric Environ Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e0241246","DOI":"10.1371\/journal.pone.0241246","article-title":"Coxiella burnetii in slaughterhouses in Brazil: a public health concern","volume":"15","author":"Mioni M de","year":"2020","journal-title":"PLoS ONE."},{"key":"B30","doi-asserted-by":"publisher","first-page":"106258","DOI":"10.1016\/j.actatropica.2021.106258","article-title":"Molecular detection of Coxiella burnetii in aborted bovine fetuses in Brazil","volume":"227","author":"Mioni M de","year":"2022","journal-title":"Acta Trop."},{"key":"B31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.actatropica.2018.04.010","article-title":"Coxiella burnetii in dairy goats with a history of reproductive disorders in Brazil","volume":"183","author":"de Oliveira","year":"2018","journal-title":"Acta Trop."},{"key":"B32","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3390\/tropicalmed7100252","article-title":"Seropositivity of anti-toxoplasma gondii antibodies in owners and their dogs living on island and mainland seashore areas of southern Brazil","volume":"7","author":"Freitas","year":"2022","journal-title":"Trop Med Infect Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"100353","DOI":"10.1016\/j.onehlt.2021.100353","article-title":"One Health approach on human seroprevalence of anti-Toxocara antibodies, Toxocara spp. eggs in dogs and sand samples between seashore mainland and island areas of southern Brazil","volume":"13","author":"Delai","year":"2021","journal-title":"One Health."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1002\/jcop.22880","article-title":"COVID-19 and vulnerable populations","volume":"50","author":"Lewis","year":"2022","journal-title":"J Community Psychol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e0003898","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global morbidity and mortality of leptospirosis: a systematic review","volume":"9","author":"Costa","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"135","DOI":"10.20506\/rst.38.1.2948","article-title":"Opportunities for One Health policies to reduce poverty: -EN- -FR- Le potentiel de l'approche Une seule sant\u00e9 en mati\u00e8re de r\u00e9duction de la pauvret\u00e9 -ES- Las pol\u00edticas en clave de Una sola salud abren posibilidades para reducir la pobreza","volume":"38","author":"Kakkar","year":"2019","journal-title":"Rev Sci Tech OIE."},{"key":"B37","first-page":"1","article-title":"Diagnosis and management of Q fever\u2013United States, 2013: recommendations from CDC and the Q Fever working group","volume":"62","author":"Anderson","year":"2013","journal-title":"MMWR Recomm Rep."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1643457\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T13:17:18Z","timestamp":1755523038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1643457\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":37,"alternative-id":["10.3389\/fpubh.2025.1643457"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1643457","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"article-number":"1643457"}}