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Originating in the mid-to-late 20th century, DHTs have facilitated substantial progress in personalized medicine, predictive analytics, and remote patient monitoring through the implementation of artificial intelligence (AI), wearable devices, and telemedicine platforms. During the Coronavirus Disease 2019 (COVID-19) pandemic, these technologies proved indispensable for epidemic surveillance and precision containment, while also mitigating healthcare access disruptions. Nevertheless, critical challenges including the digital ethics and equity, technical and regulatory policy restrictions, privacy and data security concerns, and clinical workflow integration issues remain to be addressed. This narrative review explores the transformative role of DHTs throughout the disease management continuum\u2014from prevention to prognosis\u2014and evaluates their contributions to healthcare quality and safety. It also provides strategies for stakeholders to address existing barriers. By overcoming these challenges, DHTs can further elevate healthcare standards, fostering a safer and more efficient global healthcare system.<\/jats:p>","DOI":"10.3389\/fpubh.2025.1646802","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:31:05Z","timestamp":1758864665000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Digital health: current applications, challenges, and future directions for enhancing healthcare quality and safety"],"prefix":"10.3389","volume":"13","author":[{"given":"Saidi","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siran","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jailson da","family":"Gra\u00e7a Esp\u00edrito Santo Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonilde Lavres Ceita","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Neob\u00edsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monazeri Lima Bragan\u00e7a","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Etchu Takounjou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karem Maimite Das","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzimery","family":"dos Ramos da Concei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinela","family":"da Costa Encarna\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.36255\/exon-publications-digital-health","volume-title":"Digital health","author":"Linwood","year":"2022"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3233\/SHTI200696","article-title":"What is digital health? 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