{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:48:45Z","timestamp":1792003725232,"version":"4.4.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression in cervical cancer (CC) patients concurrently compromises disease management and quality of life. However, significant discrepancies persist among existing studies regarding the determinants of depression in this population worldwide. To address this gap, this study employs meta-analysis to systematically identify and synthesize the contributing factors to depression among cervical cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To provide evidence-based references for mitigating depression risk among cervical cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature was searched in databases including CNKI, Wanfang, VIP, CBM, Web of Science, PubMed, and EMBASE from their inception until March 2025. The literature was screened, selected, quality assessed, and data extracted and analyzed. Meta-analysis was conducted using Revman 5.4 and Stata 18 software, with odds ratios (OR) and their 95% confidence intervals (CI) as the observed indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1,108 articles were retrieved, with 15 articles ultimately included in the analysis. The results indicate that low educational attainment (OR = 3.25, 95% CI: 2.02\u20135.22), age \u226545 years (OR = 1.67, 95% CI: 1.09\u20132.55), inter-household monthly income disparity (OR = 3.06, 95% CI: 1.87\u20135.00), advanced tumor stage (OR = 1.99, 95% CI: 1.28\u20133.11), low social support (OR = 2.48, 95% CI: 1.95\u20133.16), moderate to severe pain (OR = 2.86, 95% CI: 1.76\u20134.65), limited disease awareness (OR = 2.58, 95% CI: 1.88\u20133.55), and undergoing hysterectomy (OR = 4.69, 95% CI: 3.03\u20137.24) are significant risk factors for depression in cervical cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The occurrence of depression in cervical cancer patients is influenced by multiple factors. Healthcare professionals and family members should conduct comprehensive assessments of patients' conditions to implement targeted prevention and intervention measures, thereby enhancing the psychological wellbeing of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/inplasy.com\/<\/jats:ext-link>\n                      , identifier: INPLASY202560039.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1657690","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:21:32Z","timestamp":1762147292000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Meta-analysis of factors influencing depression in cervical cancer patients"],"prefix":"10.3389","volume":"13","author":[{"given":"Rong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Wen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Qing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"474","DOI":"10.19401\/j.cnki.1007-3639.2021.06.06","article-title":"Guidelines for diagnosis and treatment of cervical cancer (2021 Edition)","volume":"31","year":"2021","journal-title":"Chin Oncol J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13283\/j.cnki.xdfckjz.2025.01.001","article-title":"Guidelines for cervical cancer screening in China II","volume":"34","year":"2025","journal-title":"Prog Obstet Gynecol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin."},{"key":"B4","doi-asserted-by":"publisher","first-page":"769","DOI":"10.7507\/1007-9424.202406046","article-title":"Interpretation and analysis of the Global Cancer Statistics Report 2022:a comparison between China and the world","volume":"31","author":"Yao","year":"2024","journal-title":"Chin J Bases Clin Gen Surg."},{"key":"B5","volume-title":"Relationship between Symptom Clusters and Quality Of Life in Patients With Cervical Cancer Undergoing Concurrent Chemoradiotherapy: The Mediation Effect Of Illness Perception","author":"Zhang","year":"2021"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3969\/j.issn.1006-6233.2013.11.007","article-title":"Risk factors analysis on depression psychological of patients with cervical cancer","volume":"19","author":"Li","year":"2013","journal-title":"Hebei Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3969\/j.issn.1673-5293.2018.03.014","article-title":"Investigation on coenitive emotion regulation and anxiety as well as depression in patients with cervical cancer accepting postoperative chemotherapy and their correlation analysis","volume":"29","author":"Yu","year":"2018","journal-title":"Chin J Woman Child Health Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.3802\/jgo.2018.29.e7","article-title":"Epidemiology of gynecologic cancers in China","volume":"29","author":"Jiang","year":"2018","journal-title":"J Gynecol Oncol"},{"key":"B9","author":"Xiaoping","year":"2023","journal-title":"Research on the Predictive Model and Cognitive Behavior Intervention Programme for Depression among Cervical Cancer Patients"},{"key":"B10","doi-asserted-by":"publisher","first-page":"5349","DOI":"10.1002\/cncr.24561","article-title":"Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis","volume":"115","author":"Satin","year":"2009","journal-title":"Cancer."},{"key":"B11","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S0022-3999(02)00309-4","article-title":"Depression and immune function: central pathways to morbidity and mortality","volume":"53","author":"Kiecolt-Glaser","year":"2002","journal-title":"J Psychosom Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.19791\/j.cnki.1006-6411.2021.07.009","article-title":"Related influencing factors and nursing countermeasures for depressive symptoms in postoperative cervical cancer patients","volume":"28","author":"Song","year":"2021","journal-title":"Modern Nurse."},{"key":"B13","first-page":"1247","article-title":"Investigation of the depression status of patients with cervical cancer during the radiotherapy and analysis of its influence factors","volume":"32","author":"Zhu","year":"2024","journal-title":"Chin J Fam Plann."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.13479\/j.cnki.jip.2020.03.056","article-title":"Depression and its influencing factors in patients with cervical cancer undergoing concurrent radio-therapy and chemotherapy","author":"Wang","year":"2020","journal-title":"J Int Psychiatry"},{"key":"B15","volume-title":"Depression and Quality of Life and Correlation Analysis Inpatients with Cervical Cancer during Concurrent Chemoradiotherapy","author":"Yang","year":"2018"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.19829\/j.zgfybj.issn.1001-4411.2022.18.036","article-title":"Investigation on depression and anxiety status and influencing factors in cervical cancer patients undergoing postoperative chemotherapy","volume":"37","author":"He","year":"2022","journal-title":"Mater Child Health Care Chin."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.3760\/cma.j.cn221370-20200420-00617","article-title":"Factors influencing anxiety and depression in young and middle-aged cervical cancer patients after surgery and corresponding nursing strategies","volume":"40","author":"Tang","year":"2021","journal-title":"Int J Nurs."},{"key":"B18","volume-title":"Study on Prevalence and Influencing Factors of Depressive and Anxiety Symptoms in Postoperative Patients with Cervical Cancer","author":"Sun","year":"2013"},{"key":"B19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3760\/cma.j.issn.1673-4351.2020.02.010","article-title":"Negative emotion survey and risk factor analysis in patients with cervical cancer","volume":"4","author":"You","year":"2019","journal-title":"Doctor."},{"key":"B20","doi-asserted-by":"publisher","first-page":"766","DOI":"10.16295\/j.cnki.0257-358x.2019.08.013","article-title":"Analysis of risk factors of depression in patients with cervical cancer and its correlation with TCM constitution","volume":"38","author":"Ke","year":"2019","journal-title":"Shandong J Tradit Chin Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.19538\/j.fk2019090120","article-title":"Analysis of depression and anxiety status and related factors in patients receiving postoperative chemotherapy for cervical cancer","volume":"35","author":"Wang","year":"2019","journal-title":"Chin J Pract Gynecol Obstet."},{"key":"B22","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3969\/j.issn.1005-4561.2020.09.024","article-title":"Investigation of psychological status and related factors in cervical cancer patients undergoing postoperative chemotherapy","volume":"30","author":"Lao","year":"2020","journal-title":"Zhejiang J Int Tradit Chin West Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.13479\/j.cnki.jip.2024.05.024","article-title":"The risk factors of depression in patients undergoing cervical cancer radical surgery","volume":"51","author":"Zhu","year":"2024","journal-title":"J Int Psychiatry."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1009-5519.2021.21.004","article-title":"Establishment of the nomogram model for predicting the risk factors of depression after cervical cancer surgery","author":"Zou","year":"2021","journal-title":"J Mod Med Health"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/IGC.0b013e3181e4a704","article-title":"Prevalence and predictors of anxiety and depression among cervical cancer survivors in Korea","volume":"20","author":"Kim","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"B26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3969\/j.1674-4055.2012.04.004","article-title":"Meta-analysis series part IV: quality assessment tools for observational studies","volume":"4","author":"Zeng","year":"2012","journal-title":"Chin J Evid Based Cardiovasc Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.16821\/j.cnki.hsjx.2018.05.005","article-title":"The Joanna Briggs institute critical appraisal tools for use in systematic review. Prevalence study and analytical cross sectional study","volume":"33","author":"Zhou","year":"2018","journal-title":"J Nurs Train"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.3969\/j.issn.1004-5775.2024.18.005","article-title":"Analysis of suicide risk in patients with depression and its related influencing factors","volume":"48","author":"Hong","year":"2024","journal-title":"Heilongjiang Med J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"659470","DOI":"10.3389\/fpsyt.2021.659470","article-title":"Prevalence of major depressive disorder among adults in china: a systematic review and meta-analysis","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.19793\/j.cnki.1006-6411.2022.18.012","article-title":"Comparative analysis of psychological distress in advanced cancer patients across different age groups","volume":"29","author":"Zhang","year":"2022","journal-title":"Modern Nurse."},{"key":"B32","first-page":"1975","article-title":"Relationship between hope and depression among patients undergoing chemotherapy after radical resection of rectal neoplasms","volume":"23","author":"Wei","year":"2019","journal-title":"Anhui Med Pharm J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.11735\/j.issn.1671-170X.2018.12.B012","article-title":"Effects of psychological intervention on depression and quality of life in breast cancer patients undergoing adjuvant chemotherapy","volume":"24","author":"Chen","year":"2018","journal-title":"J Chin Oncol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3969\/j.issn.1000-0399.2024.09.021","article-title":"Analysis of depression influencing factors in cancer patients based on lasso-logistic regression and random forest models","volume":"45","author":"Zhou","year":"2024","journal-title":"Anhui Med J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.11997\/nitcwm.202501033","article-title":"Wang J. Influencing factors and intervention strategies of postoperative anxiety, depression and psychosocial adaptation status in patients with thyroid cancer","volume":"11","author":"Fang","year":"2025","journal-title":"J Clin Nurs Pract"},{"key":"B36","doi-asserted-by":"publisher","first-page":"101328","DOI":"10.1016\/j.tranon.2021.101328","article-title":"Factors associated with and risk factors for depression in cancer patients - A systematic literature review","volume":"16","author":"Riedl","year":"2022","journal-title":"Transl Oncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"826","DOI":"10.11915\/j.issn.1671-5403.2022.11.177","article-title":"Insomnia in the elderly adults with advanced cancer: a national multi-center survey","volume":"21","author":"Pang","year":"2022","journal-title":"Chin J Multi Organ Dis Elder"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.3969\/j.issn.1006-3110.2022.11.020","article-title":"Wang J. Investigation of influencing factors for depressive mood in patients with advanced gastric cancer and its relationship with chemotherapy tolerance","volume":"29","author":"Wang","year":"2022","journal-title":"Pract Prevent Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3969\/j.issn.1000-1905.2021.05.024","article-title":"Relationship between perceived social support and depression in cervical cancer patients during chemotherapy: the intermediary mechanism of rumination","volume":"55","author":"Liu","year":"2021","journal-title":"J Harbin Med Univ."},{"key":"B40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/NCC.0000000000001146","article-title":"Social support and life satisfaction in women with cervical cancer: a serial multiple mediation model","volume":"47","author":"Li","year":"2024","journal-title":"Cancer Nurs."},{"key":"B41","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/medicina58040507","article-title":"Risk factors and predictive value of depression and anxiety in cervical cancer patients","volume":"58","author":"Tosic Golubovic","year":"2022","journal-title":"Medicina"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3318","DOI":"10.3760\/cma.j.cn115682-20210226-00881","article-title":"Analysis of psychological distress and its influencing factors in postoperative lung cancer patients","volume":"27","author":"Chen","year":"2021","journal-title":"Chin J Mod Nurs."},{"key":"B43","doi-asserted-by":"publisher","first-page":"129","DOI":"10.11997\/nitcwm.202406039","article-title":"Analysis of depressive status, cancer-related fatigue, and their influencing factors in breast cancer patients","volume":"10","author":"Wu","year":"2024","journal-title":"J Clin Nurs Pract."},{"key":"B44","doi-asserted-by":"publisher","first-page":"977","DOI":"10.6004\/jnccn.2019.0038","article-title":"Adult cancer pain, version 3","volume":"17","author":"Swarm","year":"2019","journal-title":"J Natl Compr Canc Netw."},{"key":"B45","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1001\/jamapsychiatry.2018.0284","article-title":"Longitudinal associations among bullying by peers, disordered eating behavior, and symptoms of depression during adolescence","volume":"75","author":"Lee","year":"2018","journal-title":"JAMA Psychiatry."},{"key":"B46","doi-asserted-by":"publisher","first-page":"21466","DOI":"10.1038\/s41598-022-25068-7","article-title":"Cognitive behavioral therapy for anxiety and depression in cancer survivors: a meta-analysis","volume":"12","author":"Zhang","year":"2022","journal-title":"Sci Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/pon.4100","article-title":"Trajectories of total depression and depressive symptoms in prostate cancer patients receiving six months of hormone therapy","volume":"26","author":"Sharpley","year":"2017","journal-title":"Psychooncology."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1007\/s00520-020-05383-3","article-title":"Effects of Internet-based psycho-educational interventions on mental health and quality of life among cancer patients: a systematic review and meta-analysis","volume":"28","author":"Wang","year":"2020","journal-title":"Support Care Cancer."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1007\/s11606-020-06204-3","article-title":"Psychological distress and access to mental health services among cancer survivors: a national health interview survey analysis","volume":"36","author":"Arega","year":"2021","journal-title":"J Gen Intern Med."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1657690\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:22:34Z","timestamp":1762147354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1657690\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":49,"alternative-id":["10.3389\/fpubh.2025.1657690"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1657690","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"article-number":"1657690"}}