{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:19:34Z","timestamp":1788455974395,"version":"build-2803163510"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension is a leading contributor to cardiovascular disease and early mortality, and its impact is growing rapidly in low-income countries. In the Central African Republic, the condition represents a major and under-addressed health problem. This study examines the outcomes of hypertension care in Bangui, focusing on factors influencing blood pressure control and reduction (CAR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study analyzed clinical records of hypertensive patients receiving care in Bangui. Demographic and clinical data were collected at baseline and at the most recent follow-up (October-November 2024) to identify factors associated with BP control (&amp;lt;140\/90 mmHg) and reduction (decrease of \u226520 mmHg in systolic or \u226510 mmHg in diastolic BP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 656 patients (69% female, median age 59 years). BP control and clinically significant BP reduction were achieved in 39.5 and 86.7% of patients. Diabetes was an independent predictor of lower BP control (OR = 0.36; 95%CI:0.25\u20130.52;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001) and lower BP reduction (OR = 0.56; 95%CI:0.35\u20130.88;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012). Chronic kidney disease was associated with lower BP reduction (OR = 0.10; 95%CI:0.02\u20130.52;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006). Higher baseline hypertension correlated with BP reduction (Grade 3 hypertension: OR = 88.3; 95%CI:23.4\u2013587;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). Older age was associated with BP reduction (OR = 1.16; 95%CI:1.04\u20131.29;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In Bangui, structured hypertension care proved feasible and led to significant BP reductions, although target control rates remained low, particularly in patients with diabetes and CKD. Strengthening follow-up and access to tailored treatment could improve outcomes in this fragile setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1664189","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:29:42Z","timestamp":1761715782000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypertension outcomes in a fragile setting: predictors of blood pressure reduction and control in the Central African Republic"],"prefix":"10.3389","volume":"13","author":[{"given":"Anna Maria","family":"Doro Altan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Tchenebou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevine","family":"Iffio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Bortolot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Guidotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Petrolati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Somse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Ciccacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"B1","article-title":"Global 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