{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T15:00:30Z","timestamp":1763391630741,"version":"3.45.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>China consistently ranked among the top three contributors to global pertussis cases from 2021 to 2024. However, limited research on the accessibility of pertussis vaccines from a supply\u2013demand perspective has hindered effective control measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A birth cohort-stratified survey was conducted in Hubei Province, China, from March to August 2024. Data on the geographical, awareness-related, and economic accessibility of pertussis vaccination services were collected using electronic questionnaires and field surveys, targeting vaccination staff (supply-side) and caregivers of eligible children (demand-side). Influencing factors were analyzed using the \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test and univariate and multivariate logistic regression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1,350 vaccination staff members from 914 clinics and 1,098 caregivers of eligible children across 17 prefecture-level cities were surveyed. Geographically, 80% of vaccination staff members reported that their clinic\u2019s nearest clients lived within 2\u202fkm, and 89.89% of caregivers of eligible children traveled &amp;lt;30\u202fmin for vaccination. Average awareness rates were 72.92% for vaccination staff and 69.90% for caregivers of eligible children (\n                      <jats:italic>\n                        \u03c7\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:italic>\n                      \u202f=\u202f14.887,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Among vaccination staff, female individuals and those aged \u226430\u202fyears with college education, senior titles, or more than 15\u202fyears of experience showed \u22652-fold higher odds of having good awareness. Caregivers of eligible children who held a college degree, worked in medical professions, resided in urban residence, fulfilled maternal\/grandmaternal roles, had an income of \u2265100,000 CNY, or had infants aged \u226412\u202fmonths showed 1.5\u20132.6-fold higher awareness. Economically, 93.11% of vaccination staff worked in clinics that provided free National Immunization Program (NIP) pertussis vaccines (DTaP), and 87.80% of caregivers of eligible children were willing to pay for non-NIP pertussis vaccines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The geographical and economic accessibility of pertussis vaccination services is relatively reasonable in Hubei Province, China. However, knowledge gaps still exist on both the supply and demand sides. Targeted training for older, male, or less-experienced vaccination staff, along with customized education for rural, low-income, male caregivers of eligible children, could help bridge these gaps and reduce the disease burden in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1669984","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:56:03Z","timestamp":1763391363000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Accessibility of pertussis vaccine immunization services in Hubei Province from a supply\u2013demand coupling perspective"],"prefix":"10.3389","volume":"13","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhua","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"ftv050","DOI":"10.1093\/femspd\/ftv050","article-title":"Seroprevalence studies of pertussis: what have we learned from different immunized populations","volume":"73","author":"Barkoff","year":"2015","journal-title":"Pathog Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"638","DOI":"10.19914\/j.CJVI.2022119","article-title":"Epidemiological characteristics of pertussis in China, 2018-2021","volume":"28","author":"Wu","year":"2022","journal-title":"Chin J Vaccines Immun"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.19914\/j.CJVI.2024007","article-title":"Epidemiological characteristics of pertussis in China, 2022","volume":"30","author":"Zhang","year":"2024","journal-title":"Chin J Vaccines Immun"},{"year":"","key":"ref5"},{"key":"ref6","first-page":"709","article-title":"Chinese pertussis action plan: expert consensus","volume":"55","year":"2021","journal-title":"Chin J Prev Med"},{"year":"","key":"ref7"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"7000","DOI":"10.1016\/j.vaccine.2014.10.018","article-title":"Pertussis vaccine for adults: knowledge, attitudes, and vaccine receipt among adults with children in the household","volume":"32","author":"Suryadevara","year":"2014","journal-title":"Vaccine"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40520-021-02018-3","article-title":"Improving vaccination rates in older adults and at-risk groups: focus on pertussis","volume":"34","author":"Choi","year":"2022","journal-title":"Aging Clin Exp Res"},{"year":"2020","key":"ref10"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3761\/j.issn.2096-7446.2024.01.015","article-title":"Development and psychometric evaluation of a knowledge-attitude-practice questionnaire for ICU nurses on targeted temperature management in patients with severe traumatic brain injury","volume":"5","author":"Zhu","year":"2024","journal-title":"Chin J Emerg Crit Care Nurs"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1016\/S0140-6736(24)00850-X","article-title":"Contribution of vaccination to improved survival and health: modelling 50 years of the expanded Programme on immunization","volume":"403","author":"Shattock","year":"2024","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1371258","DOI":"10.3389\/fpubh.2024.1371258","article-title":"Trends and projections of age-appropriate vaccination coverage in 41 low- and middle- income countries in Asia and sub-Saharan Africa, 2000-2030","volume":"12","author":"Islam","year":"2024","journal-title":"Front Public Health"},{"year":"","key":"ref14"},{"year":"","key":"ref15"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.11847\/zgggws2015-31-08-15","article-title":"Accessibility of hepatitis B vaccination service among rural adults in Hebei province","volume":"31","author":"Liu","year":"2015","journal-title":"Chin J Public Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01037-2","article-title":"Global, regional, and national trends in routine childhood vaccination coverage from 1980 to 2023 with forecasts to 2030: a systematic analysis for the global burden of disease study 2023","year":"2025","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2030623","DOI":"10.1080\/21645515.2022.2030623","article-title":"Vaccination coverage determinants in low uptake areas of China: a qualitative study of provider perspectives in Sichuan, Guangdong, and Henan provinces","volume":"18","author":"Lin","year":"2022","journal-title":"Hum Vaccin Immunother"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.vaccine.2019.09.097","article-title":"Differential determinants and reasons for the non- and partial vaccination of children among Nigerian caregivers","volume":"38","author":"Sato","year":"2020","journal-title":"Vaccine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s40249-023-01134-8","article-title":"Prevalence and factors associated with pentavalent vaccination: a cross-sectional study in southern China","volume":"12","author":"Xu","year":"2023","journal-title":"Infect Dis Poverty"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"6036","DOI":"10.1016\/j.vaccine.2023.08.045","article-title":"Mumps vaccine hesitancy: current evidence and an evidence-based campaign in Japan","volume":"41","author":"Ugai","year":"2023","journal-title":"Vaccine"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12889-022-12573-7","article-title":"Disparities in HPV vaccine knowledge and adolescent HPV vaccine uptake by parental nativity among diverse multiethnic parents in New Jersey","volume":"22","author":"Anuforo","year":"2022","journal-title":"BMC Public Health"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3390\/vaccines9070713","article-title":"Healthcare providers' vaccine perceptions, hesitancy, and recommendation to patients: a systematic review","volume":"9","author":"Lin","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.3390\/vaccines10122013","article-title":"Beliefs and sociodemographic and occupational factors associated with vaccine hesitancy among health workers","volume":"10","author":"de Ara\u00fajo","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/1471-2458-11-239","article-title":"Does improving maternal knowledge of vaccines impact infant immunization rates? A community-based randomized-controlled trial in Karachi, Pakistan","volume":"11","author":"Owais","year":"2011","journal-title":"BMC Public Health"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2069427","DOI":"10.1080\/21645515.2022.2069427","article-title":"Measuring parents' acceptance of non-national immunization program vaccines for children and its influencing factors during the COVID-19 pandemic in Shanghai, China","volume":"18","author":"Wu","year":"2022","journal-title":"Hum Vaccin Immunother"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1016\/S2214-109X(17)30072-4","article-title":"Mobile phone-delivered reminders and incentives to improve childhood immunisation coverage and timeliness in Kenya (M-SIMU): a cluster randomised controlled trial","volume":"5","author":"Gibson","year":"2017","journal-title":"Lancet Glob Health"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e072990","DOI":"10.1136\/bmjopen-2023-072990","article-title":"Health system barriers to timely routine measles vaccinations in rural Southwest China: a qualitative study on the perspectives of township vaccination professionals and village doctors","volume":"13","author":"Cheng","year":"2023","journal-title":"BMJ Open"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e005035","DOI":"10.1136\/bmjgh-2021-005035","article-title":"Short message service (SMS) reminders for childhood immunisation in low-income and middle-income countries: a systematic review and meta-analysis","volume":"6","author":"Eze","year":"2021","journal-title":"BMJ Glob Health"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1071\/HC14304","article-title":"Factors contributing to high immunisation coverage among New Zealand Asians","volume":"6","author":"Pal","year":"2014","journal-title":"J Prim Health Care"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1669984\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:56:09Z","timestamp":1763391369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1669984\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":30,"alternative-id":["10.3389\/fpubh.2025.1669984"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1669984","relation":{},"ISSN":["2296-2565"],"issn-type":[{"type":"electronic","value":"2296-2565"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"article-number":"1669984"}}