{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:51:32Z","timestamp":1770231092744,"version":"3.49.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>High alcohol use (HAU) is a major global public health concern, contributing to injuries such as Self-harm and interpersonal violence (SIV), Transport injuries (TI), and Unintentional injuries (UII). However, comprehensive global assessments of HAU-related injury burden remain limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from Global Burden of Disease (GBD) 2021, we estimated HAU-related mortality and disability-adjusted life years (DALYs) from 1990 to 2021 across 204 countries and regions. We analyzed trends in Age-Standardized Disability-Adjusted Life Years Rate (ASDR) and Age-Standardized Mortality Rate (ASMR), examined Socio-demographic index (SDI) disparities, and employed age-period-cohort (APC) and Bayesian APC (BAPC) models for future projections. Frontier analysis identified countries with the greatest potential for burden reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite the decline in ASDR and ASMR in overall global injuries, Low-middle SDI regions continue to experience increasing SIV and TI burdens (ASDR rose from 57.25 to 70.55; 25.08 to 30.8 respectively), while UII remains high in High-middle and High SDI countries (The ASDR were 57.94 and 59.12 respectively). Young adults and the elderly bear the greatest burden. BAPC projections indicate that China, India, and several high-burden nations will see further increases in DALYs and ASDR by 2030, highlighting the need for urgent interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Targeted policy measures, such as raising the legal drinking age, strengthening alcohol control for young people in Low and Low-middle-SDI regions, and enhancing older adults healthcare services in High-SDI regions, are essential to mitigate HAU-related injuries. Evidence-based, SDI-adapted strategies can significantly reduce this burden.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2025.1675607","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T05:32:09Z","timestamp":1760592729000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Global burden and trends of high alcohol use-related injuries from 1990 to 2030: a comprehensive assessment of self-harm and interpersonal violence, transport injuries, and unintentional injuries using global burden of disease 2021"],"prefix":"10.3389","volume":"13","author":[{"given":"Qiheng","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianjin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenzhi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongliang","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e176345","DOI":"10.1172\/JCI176345","article-title":"Alcohol-associated liver disease","volume":"134","author":"Mackowiak","year":"2024","journal-title":"J Clin Invest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1111\/add.13757","article-title":"The relationship between different dimensions of alcohol use and the burden of disease\u2014an update","volume":"112","author":"Rehm","year":"2017","journal-title":"Addiction."},{"key":"B3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0140-6736(18)32850-2","article-title":"An evaluation of the effects of lowering blood alcohol concentration limits for drivers on the rates of road traffic accidents and alcohol consumption: a natural experiment","volume":"393","author":"Haghpanahan","year":"2019","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/1524838015589253","article-title":"Association between substance use and the perpetration of family violence in industrialized countries: a systematic review","volume":"18","author":"Choenni","year":"2017","journal-title":"Trauma Violence Abuse."},{"key":"B5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nrgastro.2013.86","article-title":"Genetics and alcoholism","volume":"10","author":"Edenberg","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13011-016-0081-2","article-title":"Alcohol consumption as a risk factor for global burden of disease. 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