{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:31:27Z","timestamp":1763965887372,"version":"3.45.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Human leptospirosis is a widespread zoonosis with endemic appearance in different parts of the world. Despite causing more than 1 million cases, nearly 60.000 deaths and 3 million disability-adjusted life-years per year, leptospirosis remains an underrecognized and neglected disease calling for multinational surveillance and international collaboration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The leptospirosis registry\n                      <jats:italic>LeptoScope<\/jats:italic>\n                      is a novel project enabling both international and multi-disciplinary research on\n                      <jats:italic>Leptospira<\/jats:italic>\n                      -caused diseases.\n                      <jats:italic>LeptoScope<\/jats:italic>\n                      has an electronic case report form and can be assessed on the General Data Protection Regulation compliant platform\n                      <jats:uri>clinicalsurveys.net<\/jats:uri>\n                      . Due to its modular structure,\n                      <jats:italic>LeptoScope<\/jats:italic>\n                      depicts or hides items according to the documented case (e.g., patients treated in outpatient setting versus patient admitted to the intensive care unit). This ensures rapid, but standardized enrolment of patients even in epidemics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Information collected in\n                      <jats:italic>LeptoScope<\/jats:italic>\n                      include demographics, pre-existing diseases, clinical presentation and measures in addition to outcome. A multinational research team from Germany, Belgium and Spain contributed a pilot cohort of 78 cases with\n                      <jats:italic>Leptospira<\/jats:italic>\n                      -associated diseases to confirm\n                      <jats:italic>LeptoScope\u2019s<\/jats:italic>\n                      functionality and practicality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>LeptoScope<\/jats:italic>\n                      is to our knowledge the first worldwide research platform on public health and clinical studies concerning\n                      <jats:italic>Leptospira<\/jats:italic>\n                      -associated diseases.\n                      <jats:italic>LeptoScope<\/jats:italic>\n                      promotes the needed collaboration at the cross-roads of public health, microbiology, infectious diseases and nephrology for an underrecognized and often neglected disease. Ensuring controlled or uncontrolled level II evidence\n                      <jats:italic>LeptoScope<\/jats:italic>\n                      may improve patient care and may provide evidence for robust treatment recommendations in future.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1687249","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:28:18Z","timestamp":1763965698000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and set-up of the leptospirosis registry LeptoScope for epidemiology, outbreaks and clinical studies on human leptospirosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Sadrija","family":"Cukoski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Theo","family":"Brehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Van Praet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Dolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Eberwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iker","family":"Falces-Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Wanken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman-Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Burst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix C.","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"Bharti","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1469-0691.2011.03474.x","article-title":"Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world","volume":"17","author":"Hartskeerl","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e0003898","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global morbidity and mortality of leptospirosis: a systematic review","volume":"9","author":"Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s10096-019-03797-4","article-title":"Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review","volume":"39","author":"Karpagam","year":"2020","journal-title":"Eur J Clin Microbiol Infectious Diseases"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e0004652","DOI":"10.1371\/journal.pntd.0004652","article-title":"Micronutrients and leptospirosis: a review of the current evidence","volume":"10","author":"Herman","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"ofaf035","DOI":"10.1093\/ofid\/ofaf035","article-title":"Leptospirosis-improving healthcare outcomes for a neglected tropical disease","volume":"12","author":"Mu\u00f1oz-Zanzi","year":"2025","journal-title":"Open Forum Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0012796","DOI":"10.1371\/journal.pntd.0012796","article-title":"Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect","volume":"19","author":"Tshokey","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2015.20.4.21019","article-title":"Trends in human leptospirosis in Denmark, 1980 to 2012","volume":"20","author":"van Alphen","year":"2015","journal-title":"Euro Surveillance"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1017\/S0950268814002763","article-title":"Outbreak of leptospirosis during a scout camp in the Luxembourg Belgian province, Belgium, summer 2012","volume":"143","author":"Mori","year":"2015","journal-title":"Epidemiol Infect"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-2334-10-91","article-title":"Outbreak of leptospirosis among triathlon participants in Germany, 2006","volume":"10","author":"Brockmann","year":"2010","journal-title":"BMC Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/idr16050069","article-title":"Leptospirosis incidence post-flooding following storm Daniel: the first case series in Greece","volume":"16","author":"Poulakida","year":"2024","journal-title":"Infect Dis Rep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/s41558-022-01426-1","article-title":"Over half of known human pathogenic diseases can be aggravated by climate change","volume":"12","author":"Mora","year":"2022","journal-title":"Nat Clim Chang"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s15010-018-1181-x","article-title":"Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center","volume":"46","author":"Brehm","year":"2018","journal-title":"Infection"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.vetmic.2009.03.012","article-title":"Leptospira and Leptospirosis","volume":"140","author":"Adler","year":"2010","journal-title":"Vet Microbiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1007\/s00467-008-0811-4","article-title":"The kidney in leptospirosis","volume":"23","author":"Abdulkader","year":"2008","journal-title":"Pediatric Nephrol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/clinids\/21.1.1","article-title":"Leptospirosis","volume":"21","author":"Farr","year":"1995","journal-title":"Clin Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1159\/000480691","article-title":"Leptospirosis renal disease: emerging culprit of chronic kidney disease unknown etiology","volume":"138","author":"Yang","year":"2018","journal-title":"Nephron"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-3-662-45059-8_5","article-title":"Leptospirosis in humans","volume":"387","author":"Haake","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","article-title":"Leptospirosis","volume":"14","author":"Levett","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cmi.2015.04.022","article-title":"Neglected bacterial zoonoses","volume":"21","author":"Chikeka","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e0004105","DOI":"10.1371\/journal.pntd.0004105","article-title":"Overlooked risk for chronic kidney disease after Leptospiral infection: a population-based survey and epidemiological cohort evidence","volume":"9","author":"Yang","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1093\/ndt\/gfad030","article-title":"Long-term kidney outcomes after leptospirosis: a prospective multicentre cohort study in Thailand","volume":"38","author":"Phannajit","year":"2023","journal-title":"Nephrology Dialysis Transplantation"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1093\/ckj\/sfab070","article-title":"Fighting the unbearable lightness of neglecting kidney health: the decade of the kidney","volume":"14","author":"Vanholder","year":"2021","journal-title":"Clin Kidney J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S0140-6736(12)60572-8","article-title":"Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study","volume":"380","author":"Tonelli","year":"2012","journal-title":"Lancet"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e76549","DOI":"10.1371\/journal.pone.0076549","article-title":"Towards the burden of human leptospirosis: duration of acute illness and occurrence of post-leptospirosis symptoms of patients in the Netherlands","volume":"8","author":"Goris","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e19303","DOI":"10.1016\/j.heliyon.2023.e19303","article-title":"\"We don't really do doctors.\" Messages from people diagnosed with occupational leptospirosis for medical professionals on infection, hospitalisation, and long-term effects","volume":"9","author":"Prinsen","year":"2023","journal-title":"Heliyon"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e0004122","DOI":"10.1371\/journal.pntd.0004122","article-title":"Global burden of leptospirosis: estimated in terms of disability adjusted life years","volume":"9","author":"Torgerson","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e0011291","DOI":"10.1371\/journal.pntd.0011291","article-title":"Global, regional, and country-level cost of leptospirosis due to loss of productivity in humans","volume":"17","author":"Agampodi","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1093\/ckj\/sfab053","article-title":"Development and design of the hantavirus registry - HantaReg - for epidemiological studies, outbreaks and clinical studies on hantavirus disease","volume":"14","author":"Koehler","year":"2021","journal-title":"Clin Kidney J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1111\/myc.12963","article-title":"ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies","volume":"62","author":"Koehler","year":"2019","journal-title":"Mycoses"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/myc.12631","article-title":"FungiScope(\u2122) -global emerging fungal infection registry","volume":"60","author":"Seidel","year":"2017","journal-title":"Mycoses"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10654-019-00500-x","article-title":"Guidelines and recommendations for ensuring good epidemiological practice (GEP): a guideline developed by the German Society for Epidemiology","volume":"34","author":"Hoffmann","year":"2019","journal-title":"Eur J Epidemiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"Clinical practice guideline for the evaluation and Management of Chronic Kidney Disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/zph.13027","article-title":"Investigation and response to a large outbreak of leptospirosis in field workers in Lower Saxony, Germany","volume":"70","author":"Dreesman","year":"2023","journal-title":"Zoonoses Public Health"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"602","DOI":"10.15585\/mmwr.mm7327a1","article-title":"Human case of leptospirosis during a canine disease outbreak - Wyoming, 2023","volume":"73","author":"Waranius","year":"2024","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3201\/eid3008.231562","article-title":"Outbreak of intermediate species Leptospira venezuelensis spread by rodents to cows and humans in L. interrogans-endemic region, Venezuela","volume":"30","author":"Caraballo","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"ref37","year":"2025"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1056\/NEJMc1603789","article-title":"Recognizing Data Generation","volume":"374","author":"Kalager","year":"2016","journal-title":"N Engl J Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"16569","DOI":"10.1073\/pnas.0507655102","article-title":"An index to quantify an individual's scientific research output","volume":"102","author":"Hirsch","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1001\/jama.1992.03490170092032","article-title":"A new approach to teaching the practice of medicine","volume":"268","year":"1992","journal-title":"JAMA"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1001\/jama.1995.03530200066040","article-title":"Users' guides to the medical literature. VIII. How to use clinical practice guidelines. B. What are the recommendations and will they help you in caring for your patients? The evidence-based medicine working group","volume":"274","author":"Wilson","year":"1995","journal-title":"JAMA"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1687249\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:28:18Z","timestamp":1763965698000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1687249\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":41,"alternative-id":["10.3389\/fpubh.2025.1687249"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1687249","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"article-number":"1687249"}}