{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:41:20Z","timestamp":1791380480587,"version":"4.3.3"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Online and offline social support may shape the quality of life (QoL) of people living with HIV\/AIDS (PLWHA), yet their relative and joint contributions remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional survey of 605 PLWHA in Xuzhou, gathering demographic data, subjective well-being, socioeconomic status, HIV\/AIDS knowledge, offline and online social support, and QoL. Correlation analysis, multiple linear regression, and mediation-moderation models quantified associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher socioeconomic status, greater subjective well-being, richer HIV\/AIDS knowledge, and stronger offline and online support independently predicted better QoL (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Offline support showed a direct effect on QoL (\u03b2\u202f=\u202f0.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) and an indirect effect via online support (indirect \u03b2\u202f=\u202f0.024,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Online support also improved QoL (\u03b2\u202f=\u202f0.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) but did not moderate the offline-QoL link (interaction \u03b2\u202f=\u202f0.006,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Offline support boosts QoL both directly and by fostering online support, whereas online support alone confers additional benefit without buffering deficits in offline support. Integrating face-to-face and digital support is therefore crucial for optimising patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1688797","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T05:20:37Z","timestamp":1764739237000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of online and offline social support on the quality of life of HIV\/AIDS patients: a cross-sectional study"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhiwei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanwu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/im9.0000000000000121","article-title":"From a deadly disease to a manageable chronic disease, HIV\/AIDS remains a challenge for mankind","volume":"5","author":"Shao","year":"2023","journal-title":"Infect Microbes Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/tmi.13825","article-title":"The \u20184th 90\u2019 target as a strategy to improve health-related quality of life of people living with HIV in sub-Saharan Africa","volume":"27","author":"Mvilongo","year":"2022","journal-title":"Trop Med Int Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1380731","DOI":"10.3389\/fmed.2024.1380731","article-title":"Non-AIDS-defining comorbidities impact health-related quality of life among older adults living with HIV","volume":"11","author":"Zhabokritsky","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"16535","DOI":"10.1038\/s41598-023-43434-x","article-title":"Factors associated with poorer quality of life in people living with HIV in southwestern France in 2018\u20132020 (ANRS CO3 AQUIVIH-NA cohort: QuAliV study)","volume":"13","author":"Barger","year":"2023","journal-title":"Sci Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/00006842-197609000-00003","article-title":"Presidential address\u20141976. 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