{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:31:30Z","timestamp":1793241090234,"version":"4.5.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Social Science Foundation Program of Hengyang City","award":["2023D009"],"award-info":[{"award-number":["2023D009"]}]},{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","award":["230SQT017"],"award-info":[{"award-number":["230SQT017"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze potential subtypes and influencing factors of oral frailty in older ischemic stroke patients. To support clinical professionals in precisely identifying high-risk populations and to offer a scientific foundation for the creation of tailored and accurate nursing interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 319 older ischemic stroke patients admitted to the Second Affiliated Hospital of the University of South China between December 2024 and February 2025 were selected using a convenience sampling technique. Various assessments were conducted, including the General Information Questionnaire, the Pittsburgh Sleep Quality Index, the National Institutes of Health Stroke Scale, the Geriatric Depression Scale-15, and the Oral Frailty Index-8. Different subtypes of oral frailty were explored using latent profile analysis. Univariate analysis and multinomial logistic regression were performed to investigate the factors influencing the subtypes of oral frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oral frailty in older ischemic stroke patients can be classified into three categories: oral function decline\u2014high oral frailty group (21.32%); medium in all dimensions\u2014moderate oral frailty group (27.27%); and active social participation\u2014low oral frailty group (51.41%). Multifactorial analysis indicated that age, cognitive impairment, depression, illness recurrence, living alone, albumin, total cholesterol, prothrombin time, and homocysteine are significant factors for moderate and high levels of oral frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study delineated three distinct subtypes of oral frailty. It is imperative for healthcare professionals to pay particular attention to moderate and high levels of oral frailty in older patients with ischemic stroke. Tailored care plans should be devised for various patient subgroups to enhance their oral health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1696147","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:26:27Z","timestamp":1765344387000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral frailty subtypes and influencing factors in older patients with ischemic stroke: a latent profile analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Yutong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoke","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101174","DOI":"10.1016\/j.arr.2020.101174","article-title":"A research agenda for ageing in China in the 21st century (2nd edition): focusing on basic and translational research, long-term care, policy and social networks","volume":"64","author":"Fang","year":"2020","journal-title":"Ageing Res Rev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s12603-020-1438-9","article-title":"Oral frailty","volume":"24","author":"Morley","year":"2020","journal-title":"J Nutr Health Aging"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.3761\/j.issn.0254-1769.2023.11.011","article-title":"Current situation and influencing factors of oral frailty in the community elderly","volume":"58","author":"Tu","year":"2023","journal-title":"Chin J Nurs"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1093\/gerona\/glx225","article-title":"Oral frailty as a risk factor for physical frailty and mortality in community-dwelling elderly","volume":"73","author":"Tanaka","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"112446","DOI":"10.1016\/j.exger.2024.112446","article-title":"Oral frailty is associated with mortality independently of physical and psychological frailty among older adults","volume":"191","author":"Watanabe","year":"2024","journal-title":"Exp Gerontol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.2186\/jpr.JPR_D_20_00129","article-title":"Original oral frailty and gait performance in community-dwelling older adults: findings from the Takashimadaira study","volume":"65","author":"Iwasaki","year":"2021","journal-title":"J Prosthodont Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1922\/CDH_00030Miku06","article-title":"Risk factors for oral frailty among community-dwelling pre-frail older adults in Japan: a cross-sectional analysis","volume":"40","author":"Izutsu","year":"2023","journal-title":"Community Dent Health"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"534","DOI":"10.12114\/j.issn.1007-9572.2024.0381","article-title":"Construction of conceptual framework of proactive health behavior instroke patients","volume":"28","author":"Zhou","year":"2025","journal-title":"Chin Gen Pract"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3390\/nu16081196","article-title":"Dysphagia in ischaemic stroke patients: one centre retrospective study","volume":"16","author":"Maciejewska","year":"2024","journal-title":"Nutrients"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072252","article-title":"Comprehensive evaluation of the oral health status, salivary gland function, and oxidative stress in the saliva of patients with subacute phase of stroke: a case-control study","volume":"9","author":"Gerreth","year":"2020","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1111\/ene.15846","article-title":"Early predictors of dysphagia in ischaemic stroke patients","volume":"30","author":"Mattavelli","year":"2023","journal-title":"Eur J Neurol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"110606","DOI":"10.1016\/j.nut.2019.110606","article-title":"Effect of tooth loss and nutritional status on outcomes after ischemic stroke","volume":"71","author":"Shiga","year":"2020","journal-title":"Nutrition"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.6224\/JN.202010_67(5).01","article-title":"Factors associated with oral health status and oral hygiene behavior in patients with stroke","volume":"67","author":"Shan-Yun","year":"2020","journal-title":"J Nurs"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1177\/0193945916679812","article-title":"Symptom cluster research with biomarkers and genetics using latent class analysis","volume":"39","author":"Conley","year":"2017","journal-title":"West J Nurs Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.archger.2021.104340","article-title":"Oral frailty Index-8 in the risk assessment of new-onset oral frailty and functional disability among community-dwelling older adults","volume":"94","author":"Tanaka","year":"2021","journal-title":"Arch Gerontol Geriatr"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jphys.2013.12.012","article-title":"National Institutes of Health stroke scale (NIHSS)","volume":"60","author":"Kwah","year":"2014","journal-title":"J Physiother"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11325-010-0478-5","article-title":"Reliability and validity of the Persian version of the Pittsburgh sleep quality index (PSQI-P)","volume":"16","author":"Moghaddam","year":"2012","journal-title":"Sleep Breath"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"S322","DOI":"10.1016\/jjad.2018.04.100","article-title":"Factor structure and measurement invariance of the geriatric depression scale-15","volume":"23","author":"Wongpakaran","year":"2011","journal-title":"Int Psychogeriatr"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2147\/Ndt.S17886","article-title":"Screening for cognitive decline following single known stroke using the mini-mental state examination","volume":"7","author":"Arciniegas","year":"2011","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.3390\/jcm13154556","article-title":"Oral health in patients hospitalized because of ischemic stroke","volume":"13","author":"Dziewulska","year":"2024","journal-title":"J Clin Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ijinss.2023.06.011","article-title":"Influencing factors associated with oral health among older hospitalized patients with ischemic stroke: a cross-sectional survey","volume":"10","author":"Zhao","year":"2023","journal-title":"Int J Nurs Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1457187","DOI":"10.3389\/fpubh.2024.1457187","article-title":"Prevalence and influencing factors of oral frailty in older adults: a systematic review and meta-analysis","volume":"12","author":"Zhou","year":"2024","journal-title":"Front Public Health"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.archger.2020.104014","article-title":"Association of eating alone with oral frailty among community-dwelling older adults in Japan","volume":"87","author":"Ohara","year":"2020","journal-title":"Arch Gerontol Geriatr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"104105","DOI":"10.1016\/j.archger.2020.104105","article-title":"Association between oral, social, and physical frailty in community-dwelling older adults","volume":"89","author":"Hironaka","year":"2020","journal-title":"Arch Gerontol Geriatr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/ggi.14634","article-title":"Oral frailty five-item checklist to predict adverse health outcomes in community-dwelling older adults: a Kashiwa cohort study","volume":"23","author":"Tanaka","year":"2023","journal-title":"Geriatr Gerontol Int"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3870\/j.issn.1001-4152.2023.18.112","article-title":"Oral frailty risk and its influencing factors in community-dwelling elderly population","volume":"38","author":"Wang","year":"2023","journal-title":"J Nurs Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1111\/jre.12251","article-title":"Multiple tooth loss is associated with vascular cognitive impairment in subjects with acute ischemic stroke","volume":"50","author":"Zhu","year":"2015","journal-title":"J Periodontal Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00455-017-9824-0","article-title":"The relationship between lesion localization and dysphagia in acute stroke","volume":"32","author":"Daniels","year":"2017","journal-title":"Dysphagia"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1080\/10749357.2019.1628464","article-title":"Swallowing progression during the acute phase of cortical and subcortical ischemic stroke and its association with the extension of brain damage and cognitive impairment","volume":"26","author":"Mourao","year":"2019","journal-title":"Top Stroke Rehabil"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jad.2023.10.037","article-title":"Molecular mechanisms underlying major depressive disorder and post-stroke affective disorders","volume":"344","author":"Colita","year":"2024","journal-title":"J Affect Disord"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1044\/2022_AJSLP-21-00346","article-title":"Incidence of poststroke depression in patients with Poststroke dysphagia","volume":"31","author":"Horn","year":"2022","journal-title":"Am J Speech Lang Pathol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12903-022-02259-2","article-title":"Oral health status and its associated factors among post-stroke inpatients: a cross-sectional study in Hungary","volume":"22","author":"Moldvai","year":"2022","journal-title":"BMC Oral Health"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3390\/antiox14010055","article-title":"Antioxidant properties of albumin and diseases related to obstetrics and gynecology","volume":"14","author":"Watanabe","year":"2025","journal-title":"Antioxidants"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"10760296231198042","DOI":"10.1177\/10760296231198042","article-title":"Prognostic values of prothrombin time and inflammation-related parameter in acute ischemic stroke patients after intravenous thrombolysis with rt-PA","volume":"29","author":"Zhao","year":"2023","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12031-024-02210-w","article-title":"Factors influencing early diagnosis and poor prognosis of dysphagia after senile ischemic stroke","volume":"74","author":"Fan","year":"2024","journal-title":"J Mol Neurosci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12944-024-02329-0","article-title":"Association of platelet-to-HDL cholesterol ratio with frailty and all-cause mortality","volume":"23","author":"Zhang","year":"2024","journal-title":"Lipids Health Dis"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1696147\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:26:32Z","timestamp":1765344392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2025.1696147\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":36,"alternative-id":["10.3389\/fpubh.2025.1696147"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2025.1696147","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"article-number":"1696147"}}