{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:16:40Z","timestamp":1767871000769,"version":"3.49.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alcohol use posed a significant burden to public health, contributing substantially to mortality from neurological and psychiatric disorders. Understanding trends and disparities in alcohol-induced neurological and psychiatric (AINP) mortality is crucial for informed policy and targeted interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study is to analyze trends in AINP mortality and associated demographic and geographic disparities in the US between 1999 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the CDC WONDER database were collected to identify AINP related deaths via ICD-10 codes (F10, G31.2, G62.1). Age-adjusted mortality rates (AAMRs, per 100,000 population) and annual percent changes (APCs) with 95% confidence intervals (CIs) were calculated to assess temporal trends. An autoregressive integrated moving average model was used to predict mortality rate changes in high-risk populations by 2030.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 226,785 AINP deaths were reported. AAMR increased from 2.28 (1999) to 4.17 (2023), with no significant change (1999\u20132017: APC\u202f=\u202f\u22120.04%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.934), accelerated increase (2018\u20132021: APC\u202f=\u202f18.35%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.036), followed by a modest decline (2021\u20132023: APC\u202f=\u202f\u22123.80%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.046). Female AAMR showed a higher APC (3.89%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) than males (2.55%). The Midwest showed the steepest APC (3.77%, p\u202f&amp;lt;\u202f0.001), while the South and West showed the smallest increases (APC\u202f=\u202f1.80 and 2.08%, both\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01). Mortality growth rates rosed with increasing urbanization. American Indian\/Alaska Native (AI\/AN) populations had the highest AAMR, peaking at 21.13 in 2021 (APC 2.50%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004). White people accounted for most deaths (75.69%), with AMMR increasing continuously (APC\u202f=\u202f3.45%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001)). Mortality peaked at ages 45\u201354 (crude rate: 7.86\/100,000, 26.86% of deaths), 55\u201364\u202fs most affected (30.98% of deaths). 56.85% of deaths occurred at home and 1.13% were pre-hospital. Female projections show a rising trend (APC 3.89%), while adults aged 45\u201374 show a slight decrease to 9.50 by 2030 despite a historical APC of 2.81%. Conclusions: From 1999 to 2023, US AINP mortality rosed steadily, disproportionately affecting females, AI\/AN and White populations, Midwestern residents, and middle-aged and older adults. Most deaths occurred at home, reflecting healthcare access gaps. Targeted interventions for high-risk groups and regions, along with optimized medical resources allocation, are urgently needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1712253","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:36:08Z","timestamp":1767854168000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The hidden epidemic of alcohol-induced neurological and psychiatric mortality in the U. S. 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