{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:30:16Z","timestamp":1789500616664,"version":"build-2803163510"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma remains a major cause of morbidity among school-age children worldwide, with deficiency of vitamin D increasingly recognized as a modifiable factor influencing immune regulation and respiratory health. However, evidence on its association with asthma control and exacerbation patterns in pediatric populations is limited, in low- and middle-income population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective single-center study of 320 children, 6\u201314 years, diagnosed with asthma between January 2019 and December 2023. Following application of inclusion and exclusion criteria, 210 children were analyzed. Data were obtained from medical records and structured questionnaires, including socio-demographic characteristics, asthma control status, exacerbation frequency, hospitalization history, and biochemical assays (serum vitamin D, calcium, phosphate, parathyroid hormone). Patients were categorized as vitamin D deficient, insufficient, or sufficient. Statistical analyses, including \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests, ANOVA, and multivariable logistic regression, were performed using R (v4.3.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vitamin D deficiency was prevalent in 45.2% of children, while 31.0% were insufficient and 23.8% sufficient. Poor asthma control was more common among deficient children (63.2%) compared to insufficient (43.1%) and sufficient groups (24.0%). The mean annual exacerbation rate was highest in the deficient group (2.6 \u00b1 1.3) vs. insufficient (1.9 \u00b1 1.1) and sufficient groups (1.1 \u00b1 0.9). Hospitalization rates also differed significantly (31.6, 18.5, and 12.0%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014). Multivariable logistic regression confirmed that vitamin D deficiency independently predicted poor asthma control (adjusted OR: 2.8, 95% CI: 1.6\u20134.9,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001) after adjustment for age, sex, BMI, and treatment profile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D deficiency is highly prevalent among school-age children with asthma and is independently associated with poor control, higher exacerbation frequency, and increased hospitalizations. As part of integrated pediatric asthma care, these findings emphasize the significance of routine screening and the need to take vitamin D supplements into account. At the public health level, targeted nutritional interventions may reduce disease burden and improve long-term outcomes in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1717912","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:59:56Z","timestamp":1765781996000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin D deficiency and asthma morbidity in school-age children: a single-center cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Lijuan","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"954768","DOI":"10.3389\/fnut.2022.954768","article-title":"Vitamin D status and asthma, lung function, and hospitalization among British adults","volume":"9","author":"Zhu","year":"2022","journal-title":"Front Nutr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41533-021-00239-7","article-title":"Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study","volume":"31","author":"Alkhatatbeh","year":"2021","journal-title":"NPJ Prim Care Respir Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e70828","DOI":"10.1002\/hsr2.70828","article-title":"High prevalence of uncontrolled asthma and its association with obesity and GERD-related symptoms in Syria: a multicenter cross-sectional study","volume":"8","author":"Bakdounes","year":"2025","journal-title":"Health Sci Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1186\/s12887-025-05969-y","article-title":"Association between vitamin D status and asthma control levels among children and adolescents: a retrospective cross sectional study in Saudi Arabia","volume":"25","author":"Alolayan","year":"2025","journal-title":"BMC Pediatr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.7759\/cureus.17279","article-title":"The relationship between vitamin D and asthma exacerbation","author":"Ogeyingbo","year":"2021","journal-title":"Cureus."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5516","DOI":"10.62347\/FVQP4019","article-title":"Protection against cigarette smoke-induced chronic obstructive pulmonary disease via activation of the SIRT1\/FoxO1 axis by targeting microRNA-132","volume":"16","author":"Shen","year":"2024","journal-title":"Am J Transl Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"840617","DOI":"10.3389\/fped.2022.840617","article-title":"The effect of vitamin d supplementation in children with asthma: a meta-analysis","volume":"10","author":"Hao","year":"2022","journal-title":"Front Pediatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2400313","DOI":"10.1080\/07853890.2024.2400313","article-title":"Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials","volume":"56","author":"Fedora","year":"2024","journal-title":"Ann Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1549419","DOI":"10.3389\/fphar.2025.1549419","article-title":"Efficacy of Xuebijing injection on pulmonary ventilation improvement in acute pancreatitis: a systematic review and meta-analysis","volume":"16","author":"Bin","year":"2025","journal-title":"Front Pharmacol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.3390\/nu14193947","article-title":"Vitamin D supplementation and allergic diseases during childhood: a systematic review and meta-analysis","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients."},{"key":"B11","doi-asserted-by":"publisher","first-page":"20002","DOI":"10.1038\/s41598-022-16744-9","article-title":"Developing a new sepsis screening tool based on lymphocyte count, international normalized ratio and procalcitonin (LIP score)","volume":"12","author":"Liu","year":"2022","journal-title":"Sci Rep."},{"key":"B12","unstructured":"Global Strategy for Asthma Management and Prevention\n          \n          2024"},{"key":"B13","doi-asserted-by":"publisher","first-page":"122665","DOI":"10.1016\/j.envpol.2023.122665","article-title":"et al. 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