{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:56:11Z","timestamp":1773838571438,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Italy, a major former producer, banned asbestos in 1992. A high incidence of mesothelioma, one of the asbestos legacies, is still observed due to the long latency and exposure from residual asbestos-containing materials. Future mortality forecasts at both national and subnational levels are still lacking. This work aims to project future age-stratified mortality rates (2020\u20132034) for pleural mesothelioma (PM) in Italy, both nationally and for each administrative region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data on pleural cancers and PM in Italy between 1980 and 2019 were extracted from death registries, adjusted for PM misclassification in ICD-9, and aggregated in eight periods, eighteen age classes, and fifteen birth cohorts. Bayesian age-period-cohort models were implemented to generate age-specific mortality projections, stratified by sex assigned at birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 1980 and 2019, 33,889 people died from PM in Italy, and 19,092 more deaths are expected between 2020 and 2034. The national peak is predicted for 2020\u20132024, with 6,740 deaths. Age groups under 75\u202fyears have already reached the peak of mortality rates. Region-specific trends by sex and time reflect the country\u2019s industrialization history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These results align with the literature in predicting the timing of the mesothelioma peak and offer new insights into age-specific trends, the rate of decline, and geographical patterns. They provide valuable evidence on the heterogeneous asbestos legacy across regions, supporting targeted public health actions and health planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2025.1741506","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:02:02Z","timestamp":1768572122000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Projecting future mortality risk of pleural mesothelioma in Italy (2020\u20132034): Bayesian age\u2013period\u2013cohort analysis over 40\u202fyears of death registration"],"prefix":"10.3389","volume":"13","author":[{"given":"Allegra","family":"Sartore","sequence":"first","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, DCTVPH, University of Padova","place":["Padova, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Stoppa","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, DCTVPH, University of Padova","place":["Padova, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Minelli","sequence":"additional","affiliation":[{"name":"Statistical Service, Italian National Institute of Health","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Mensi","sequence":"additional","affiliation":[{"name":"Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","place":["Milan, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Consonni","sequence":"additional","affiliation":[{"name":"Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","place":["Milan, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Manno","sequence":"additional","affiliation":[{"name":"Statistical Service, Italian National Institute of Health","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Marinaccio","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers' Compensation Authority (INAIL)","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Fazzo","sequence":"additional","affiliation":[{"name":"Department of Environment and Health, Italian National Institute of Health","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annibale","family":"Biggeri","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, DCTVPH, University of Padova","place":["Padova, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Catelan","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, DCTVPH, University of Padova","place":["Padova, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref1","article-title":"Some inorganic and organometallic compounds","volume-title":"IARC monographs on the evaluation of carcinogenic risk of chemicals to man, v. 2","year":"1973"},{"key":"ref2","first-page":"11","article-title":"Arsenic, metals, fibres, and dusts","volume":"100","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"ref3","year":"2024"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.3390\/ijerph14111433","article-title":"The tale of asbestos in Sweden 1972\u20131986\u2014the pathway to a near-total 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