{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:39:52Z","timestamp":1788172792086,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) is a global health challenge that is frequently complicated by psychiatric comorbidities, which can worsen disease outcomes and quality of life. Accurate prevalence estimates are essential to inform integrated management strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to systematically review and meta-analyze the prevalence and patterns of psychiatric comorbidities in individuals with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive search of PubMed, ScienceDirect, Google Scholar, and the Cochrane Library was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies included full-text, peer-reviewed articles reporting psychiatric comorbidities in adults with T2DM. Data extraction was performed independently by two reviewers. Pooled prevalence estimates were calculated using a random effects model, with heterogeneity assessed using the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic. The search was updated through July 2025.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 12 studies met the inclusion criteria. The pooled prevalence of depression in adults with T2DM was 19% (95% CI: 14\u201324%), based on eight contributing studies. Mild cognitive impairment (MCI) was also frequently observed, with a pooled prevalence of 39% (95% CI: 23\u201359%) across four studies. Considerable variability among studies was evident, likely attributable to differences in study design, diagnostic methods, sampling frames, and population characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Psychiatric comorbidities are highly prevalent in individuals with T2DM, particularly depression and cognitive impairment, emphasizing the need for integrated psychiatric and metabolic care. This meta-analysis demonstrates that psychiatric comorbidities, particularly depression and cognitive impairment, are common in individuals with T2DM, highlighting the need for routine psychiatric screening and integrated diabetes care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1697079","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:18:22Z","timestamp":1771305502000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence and patterns of psychiatric comorbidities in type 2 diabetes mellitus: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Muhanad Saleh","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Jeddah First Cluster, Joint Program of Family Medicine Jeddah","place":["Jeddah, Saudi 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