{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:40:15Z","timestamp":1777304415811,"version":"3.51.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To understand the prevalence of parent-reported food allergy symptoms among preschool children in Haikou City and investigate indoor environmental risk factors for it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional survey was conducted with 3,049 preschool children across eight kindergartens in Haikou City from December 2020 to January 2021. The survey aimed to analyze the influence of indoor environmental factors on parent-reported food allergy symptoms in these children. Data collection was facilitated using EpiData 3.1, while SPSS 25.0 was employed for data analysis. The Chi-square (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ) test was applied for univariate analysis, and multivariate logistic regression was utilized to examine the indoor environmental factors affecting parent-reported food allergy symptoms in children. A\n                      <jats:italic>p<\/jats:italic>\n                      -value of less than 0.05 was considered to indicate statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of parent-reported food allergy symptoms in preschool children was 9.25%. Multivariate unconditional logistic regression results suggested that age (odds ratio (OR)\u202f=\u202f1.891, 95% confidence interval (CI): 1.246\u20132.871), nationality other than the Han (OR\u202f=\u202f1.753, 95%CI: 1.097\u20132.802), mother\u2019s education level junior college and above than below junior college (OR\u202f=\u202f1.395, 95%CI: 1.051\u20131.851), family allergy history (OR\u202f=\u202f2.893, 95%CI: 2.233\u20133.748), the only child (OR\u202f=\u202f1.351, 95%CI: 1.031\u20131.770), furniture purchased in child\u2019s first year (OR\u202f=\u202f1.774, 95%CI: 1.263\u20132.493), mould on surfaces during pregnancy (OR\u202f=\u202f1.540, 95%CI: 1.025\u20132.313), damp exposure during pregnancy (OR\u202f=\u202f1.678, 95%CI: 1.120\u20132.515), exposure to passive smoking (OR\u202f=\u202f1.483, 95%CI: 1.143\u20131.925) were risk factors for parent-reported food allergy symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the significant role of the indoor home environment, alongside genetic factors, in the development of parent-reported food allergy symptoms in children. Implementing strategies to reduce indoor moisture and avoid tobacco smoke exposure is essential for preventing parent-reported food allergy symptoms in preschool-aged children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1699833","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:50:57Z","timestamp":1776837057000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and indoor environment risk factors of parent-reported food allergy symptoms among preschool children in Haikou City, China: a cross-sectional survey"],"prefix":"10.3389","volume":"14","author":[{"given":"Shoumin","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qisheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]},{"name":"Wenchang Center for Disease Control and Prevention","place":["Wenchang, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binxian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiheng","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dee","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Public Health, Hainan Academy of Medical Sciences, Hainan Medical University","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.3390\/ijerph15092043","article-title":"The epidemiology of food allergy in the global context","volume":"15","author":"Loh","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jaci.2013.11.020","article-title":"Food allergy: epidemiology, pathogenesis, diagnosis, and treatment","volume":"133","author":"Sicherer","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nri.2016.111","article-title":"Food allergy: immune mechanisms, diagnosis and immunotherapy","volume":"16","author":"Yu","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.jaci.2011.01.039","article-title":"Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants","volume":"127","author":"Osborne","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13223-016-0161-x","article-title":"Predictors of allergen sensitization in Singapore children from birth to 3 years","volume":"12","author":"Loo","year":"2016","journal-title":"Allergy Asthma Clin 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Does mother confer more risk than father?","volume":"158","author":"Litonjua","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"770913","DOI":"10.3389\/fcimb.2021.770913","article-title":"Association between breastmilk microbiota and food allergy in infants","volume":"11","author":"Wang","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000487380","article-title":"Food allergy prevention and treatment by targeted nutrition","volume":"72","author":"Heine","year":"2018","journal-title":"Ann Nutr Metab"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000443961","article-title":"In utero programming of allergic susceptibility","volume":"169","author":"Grieger","year":"2016","journal-title":"Int Arch Allergy 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Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/ACI.0000000000000101","article-title":"The evolution of the hygiene hypothesis: the role of early-life exposures to viruses and microbes and their relationship to asthma and allergic diseases","volume":"14","author":"Daley","year":"2014","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"753","DOI":"10.16506\/j.1009-6639.2023.08.001","article-title":"The prevalence of food allergy and influencing factors among preschool children in Urumqi City","volume":"24","author":"Xiaolan","year":"2023","journal-title":"Chin Prev Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"403","DOI":"10.13590\/j.cjfh.2023.03.013","article-title":"Analysis of dietary characteristics and food allergy of preschool children in Shanghai","volume":"35","author":"Lan","year":"2023","journal-title":"Chin J Food 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