{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:35:40Z","timestamp":1793885740784,"version":"4.8.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["no. 2022R1C1C1004937"],"award-info":[{"award-number":["no. 2022R1C1C1004937"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder. Despite revisions of diagnostic criteria, studies applying the Rome IV criteria in Korea are limited. Environmental factors such as climate and season have been suggested to influence the epidemiology of IBS; however, their associations remain unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the prevalence and incidence of IBS in Korea from 2019 to 2023 using clinical data from eight nationwide hospitals converted to the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). Stratified analyses were conducted by year, month, sex, and age. Seasonal variations were examined in relation to meteorological factors, including temperature and humidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both the prevalence and incidence of IBS decreased during the study period. Females consistently showed higher rates than males, although the sex gap in incidence narrowed over time. The highest incidence rates were observed in individuals aged \u226565 years and those aged 15\u201319 years. Seasonal variation was evident, with peak incidence in autumn, followed by summer, significantly correlating with humidity and temperature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This multicenter study highlights sex- and age-specific differences in IBS epidemiology in Korea and demonstrates significant seasonal associations with meteorological factors. These findings underscore the need for large-scale, prospective surveys and public health strategies to address the IBS burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1711919","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:40:14Z","timestamp":1780638014000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends and seasonal variation in the incidence and prevalence of irritable bowel syndrome in Korea: a multicenter OMOP CDM study"],"prefix":"10.3389","volume":"14","author":[{"given":"Seung-hyo","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahyun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Department of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University","place":["Seoul, Republic of Korea"]},{"name":"Department of Digestive Diseases, College of Korean Medicine, Kyung Hee University","place":["Seoul, Republic of Korea"]},{"name":"Department of Korean Internal Medicine, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University","place":["Seoul, Republic of Korea"]},{"name":"Division of Digestive Diseases, Department of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital","place":["Seoul, Republic of Korea"]},{"name":"Department of Korean Internal Medicine, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Jae","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University","place":["Seoul, Republic of Korea"]},{"name":"Department of Digestive Diseases, College of Korean Medicine, Kyung Hee University","place":["Seoul, Republic of Korea"]},{"name":"Department of Korean Internal Medicine, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong","place":["Seoul, Republic of 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