{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:30:08Z","timestamp":1769704208195,"version":"3.49.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Osteoporosis frequently affects older women and is strongly linked to their daily routines, which include both sedentary behavior (SEB) and physical activities (PA) of different intensities. This study investigates the dose\u2013response relationship of different SEB and PA patterns among community-dwelling older women and assesses the potential impact of time reallocation on osteoporosis risk through an isotemporal substitution analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 1,106 older women aged between 60 and 70\u202fyears in Tianjin participated. Their moderate to vigorous physical activity (MVPA), light physical activity (LPA), and SEB were objectively assessed using an accelerometer. The connection between MVPA, LPA, SEB, and osteoporosis was assessed using binary logistic regression models and isotemporal substitution models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The osteoporosis group and non-osteoporosis group comprised 461 and 645 subjects respectively, accounting for 41.68 and 58.32% of the total cohort. The osteoporosis group had significantly higher daily SEB compared to the non-osteoporosis group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01), whereas LPA (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05) and MVPA (p\u202f&amp;lt;\u202f0.01) were notably lower. Dose\u2013response analysis adjusted for variables revealed: increases of 60\u202fmin\/d in total SEB, as well as 10-min, 30-min, and 60-min SEB bouts, were positively correlated with the risk of osteoporosis. While increases of 30\u202fmin\/d in total, sporadic, and bouted LPA were negatively associated with osteoporosis risk. More notably, adding 10\u202fmin\/d to total, sporadic, and bouted MVPA significantly decreased the risk of osteoporosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01). Isotemporal substitution model analysis demonstrated: replacing 30\u202fmin of SEB with equivalent durations of LPA and MVPA increased osteoporosis risk by 9 and 56%, respectively. Substituting 30\u202fmin of SEB with equivalent durations of LPA and MVPA reduced osteoporosis risk by 8 and 47%, respectively. Switching 30\u202fmin of LPA with the same duration of MVPA reduced osteoporosis risk by 28%, while exchanging 30\u202fmin of MVPA with the same duration of LPA showed no significant difference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PA and SEB in older women exhibit a significant dose\u2013response relationship with osteoporosis. Avoiding prolonged sitting and increasing PA duration both offer protective effects against osteoporosis in older women, with achieving a certain level of MVPA being the most effective protective measure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1717573","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T05:22:39Z","timestamp":1769664159000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship of physical activity and sedentary behavior patterns with osteoporosis in older women: a dose\u2013response analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"College of Sports Science, Tianjin Normal University","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Li","sequence":"additional","affiliation":[{"name":"College of Sports Science, Tianjin Normal University","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e2121106","DOI":"10.1001\/jamanetworkopen.2021.21106","article-title":"Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study","volume":"4","author":"Wang","year":"2021","journal-title":"JAMA Netw Open"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s00223-014-9863-6","article-title":"The association between hip muscle cross-sectional area, muscle strength, and bone mineral density","volume":"95","author":"Ahedi","year":"2014","journal-title":"Calcif Tissue 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