{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:18:14Z","timestamp":1784085494386,"version":"3.55.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Varicella-zoster virus is an alphaherpesvirus that causes two diseases in humans: chickenpox, the primary infection, and herpes zoster (HZ). Although HZ incidence has been well-documented, relatively little is known regarding the clinical-epidemiological characteristics of HZ prodromal pain, acute pain, and subacute pain. The aim of the study was to analyse the clinical-epidemiological characteristics of HZ and postherpetic neuralgia (PHN) in cases diagnosed between 2007 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a clinical-epidemiological study of cases of HZ and PHN diagnosed between 2007 and 2020 in Hospital de Sagrado Coraz\u00f3n (Barcelona) in the first 14 days after rash onset, analyzing age, gender, dermatomes, and pain. Pain on rash diagnosis was classified as no pain, any pain, and clinically significant pain (scores 0, 1\u201310, and 3\u201310, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 589 cases of HZ were included, mean age of patients was 59.6 years and the female\/male ratio was 1.38 and cases increased with age (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.01). Of the 589 cases, 77.4% had pain on day 0 of rash onset, 34.5% at 30 days, and 11.9% at 90 days. 70 cases progressed to PHN, which also increased with age. Factors associated with PHN were age groups 70\u201379 years (aOR 4.26; 95% CI 1.36\u201313.37) and \u226580 years (aOR 3.89; 95% CI 1.18\u201312.87) and intensity of pain score at rash onset \u22657 (aOR 19.74; 95% CI 4.63\u201384.10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patient age and pain presence and intensity on day 0 and at 30 days of HZ diagnosis are the main risk factors for PHN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1743321","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T06:33:28Z","timestamp":1771310008000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical epidemiology of herpes zoster and postherpetic neuralgia in Barcelona (Spain). A single-center study"],"prefix":"10.3389","volume":"14","author":[{"given":"Montserrat","family":"Salleras","sequence":"first","affiliation":[{"name":"Dermatology Service, Hospital del Sagrado Coraz\u00f3n","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Salleras","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Barcelona","place":["Barcelona, Spain"]},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Instituto de Salud Carlos III","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Soldevila","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Barcelona","place":["Barcelona, Spain"]},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Instituto de Salud Carlos III","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Prat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Garrido","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Barcelona","place":["Barcelona, Spain"]},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Instituto de Salud Carlos III","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/003591576505800106","article-title":"The nature of herpes zoster: a long term study and a new hypothesis","volume":"58","author":"Hope-Simpson","year":"1965","journal-title":"Proc R Soc Med."},{"key":"B2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-319-44348-5_4","article-title":"The epidemiology and natural history of herpes zoster and postherpetic neuralgia","volume-title":"Herpes Zoster: Postherpetic Neuralgia and Other Complications: Focus on Treatment and Prevention","author":"Schmader","year":"2017"},{"key":"B3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1177\/2051013615599151","article-title":"Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective","volume":"3","author":"Johnson","year":"2015","journal-title":"Ther Adv Vaccines."},{"key":"B4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0264-410X(00)00178-X","article-title":"Seroepidemiology of varicella-zoster virus infection in Catalonia (Spain). 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