{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:18:50Z","timestamp":1789507130914,"version":"build-2803163510"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["CSQ24043"],"award-info":[{"award-number":["CSQ24043"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["CSQ20014"],"award-info":[{"award-number":["CSQ20014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>\n                    Maneb, a typical dithiocarbamate pesticide, is widely used in the control of agricultural fungi in lands. Its residues with main metabolites in environmental media pose risks to environmental safety and human health. This research summarized the research progress on the environmental residues, human exposure levels, neurotoxic effects and mechanisms of maneb. Epidemiological studies have shown that exposure to maneb is associated with an increased risk of neurodegenerative diseases such as Parkinson\u2019s disease (PD).\n                    <jats:italic>In vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments have further demonstrated that exposure to maneb induces neurotoxic effects in cells and animals, involving multiple injury pathways and molecular mechanisms, including reduced cell viability, oxidative stress, mitochondrial dysfunction, synaptic dysfunction, and induction of apoptosis, ultimately leading to the degeneration of dopaminergic neurons. Future research can focus on the systemic comprehensive toxicity and interaction mechanisms of maneb to promote its safe application in agricultural production.\n                  <\/jats:p>","DOI":"10.3389\/fpubh.2026.1745443","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:33:12Z","timestamp":1770013992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Advances in the neurotoxicity of ecological pesticide maneb: mechanisms and implications for human health"],"prefix":"10.3389","volume":"14","author":[{"given":"Yuping","family":"Xi","sequence":"first","affiliation":[{"name":"The College of Ethnology and Sociology, South-Central Minzu University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Environment and Health, Zhongnan University of Economics and Law","place":["Wuhan, China"]},{"name":"School of Information Engineering, Zhongnan University of Economics and Law","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziting","family":"Lin","sequence":"additional","affiliation":[{"name":"The College of Ethnology and Sociology, South-Central Minzu University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Peng","sequence":"additional","affiliation":[{"name":"Research Center for Environment and Health, Zhongnan University of Economics and Law","place":["Wuhan, China"]},{"name":"School of Information Engineering, Zhongnan University of Economics and Law","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center for Environment and Health, Zhongnan University of Economics and Law","place":["Wuhan, China"]},{"name":"School of Information Engineering, Zhongnan University of Economics and Law","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihu","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Zhongnan University of Economics and Law","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglong","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Huazhong Agricultural University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref1","year":""},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.3390\/ijerph19052632","article-title":"Time for re-evaluating the human carcinogenicity of Ethylenedithiocarbamate fungicides? 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