{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:04:03Z","timestamp":1771567443043,"version":"3.50.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stroke remains a major public health burden in China, and the complexity of long-term pharmacotherapy often places stroke survivors at high risk for drug-related problems (DRPs). This study aimed to identify determinants of DRPs among community-dwelling stroke patients in suburban Beijing and to propose targeted initiatives for improving rational drug use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted from August 2022 to December 2024 among 481 stroke patients. Pharmacists performed face-to-face interviews to collect demographic, clinical, and drug-related information. DRPs were identified and categorized using the Pharmaceutical Care Network Europe (PCNE) Classification System (V9.1). Chi-square tests and multivariate logistic regression were used to determine factors associated with DRPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 482 DRPs were identified, corresponding to 575 cause entries. The most common problems involved suboptimal treatment effectiveness and issues requiring further clarification. Patient-related causes were predominant, especially intentional underuse or non-use of drug and inappropriate timing or dosing intervals. Logistic regression showed that alcohol consumption (OR\u202f=\u202f1.770), comorbid diabetes (OR\u202f=\u202f1.818), depression\/anxiety symptoms (OR\u202f=\u202f1.733), and higher animal fat intake (OR\u202f=\u202f1.711) significantly increased DRP risk. Lower income, polypharmacy, and poorer self-rated health were also associated with DRPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DRPs were highly prevalent among community-dwelling stroke survivors, driven largely by modifiable behavioral and drug-use factors. Integrating PCNE-based DRP identification with pharmacist-led community interventions may help optimize drug management, enhance treatment safety and effectiveness, and support long-term secondary prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1771680","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:21:00Z","timestamp":1771564860000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug-related problems and their determinants among stroke patients in suburban China: a PCNE-based analysis with targeted initiatives"],"prefix":"10.3389","volume":"14","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengzhao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Huairou Hospital, Capital Medical University Huairou Teaching Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40779-023-00463-x","article-title":"China stroke surveillance report 2021","volume":"10","author":"Tu","year":"2023","journal-title":"Mil Med Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e231455","DOI":"10.1001\/jamanetworkopen.2023.1455","article-title":"Estimated burden of stroke in China in 2020","volume":"6","author":"Tu","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association\/American Stroke Association","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"II","DOI":"10.1177\/23969873221100032","article-title":"European Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack","volume":"7","author":"Dawson","year":"2022","journal-title":"Eur Stroke J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"947","DOI":"10.3760\/cma.j.cn114798-20210804-00591","article-title":"Chinese Medical Association, Chinese Medical Association publishing house, Chinese Society of General Practice, editorial Board of Chinese Journal of general practitioners of Chinese Medical Association, expert Group of Guidelines for primary Care of Nervous System Disease. 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