{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:52:24Z","timestamp":1787161944567,"version":"build-2736575974"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection remains a major public health concern in China, with prevalence and antimicrobial resistance patterns varying significantly at the subnational level. A multicenter observational study performed in Ya\u2019an city showed that the pooled average prevalence of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection was as high as 31.9% (19,058\/59,791) during 2021\u20132023, despite significantly declining form 35.6% in 2021 to 30.4% in 2023 (P for trend\u202f&amp;lt;\u202f0.0001). Moreover, men were more likely than woman to be infected in any year (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.001) or any age group (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.001), with the only exception being the 30\u201339\u202fyears age group. Additionally, the 60\u201369\u202fyears age group had highest prevalence among both males (38.7%) and females (33.5%), respectively. A sequential multicenter study in Ya\u2019an (2023\u20132024) found high antimicrobial resistance to metronidazole (96.9%), levofloxacin (45.9%), and clarithromycin (30.2%), with 17.6% multi-drug resistance. A rapid meta-analysis on four recent studies in Sichuan province (1,203 patients) found the isolation rate of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    was 70.7% (95% CI 55.8%\u201385.6%). The pooled estimate consistently confirmed those high resistance rates, although amoxicillin (0.4%), tetracycline (0.3%), and furazolidone (0%) maintained consistently extremely low resistance in Sichuan. Rifampicin resistance was quite diverse in Sichuan. These findings highlight the need for organized massive screening for\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection that should be encouraged in moderate-to-high prevalence regions at subnational level of China to identify individuals at high risk of gastric cancer. Both antimicrobial resistance prevalence-guided empirical eradication and susceptibility-guided individualized eradication require further investigations on effectiveness and cost-effectiveness to improve eradication of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.3389\/fpubh.2026.1774904","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:47:53Z","timestamp":1779256073000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Tailored screening and eradication of Helicobacter pylori at a subnational level of China: multicenter observational studies in Ya\u2019an city and a rapid meta-analysis in Sichuan province"],"prefix":"10.3389","volume":"14","author":[{"given":"Liu","family":"Wang","sequence":"first","affiliation":[{"name":"Endoscopy Center, Ya\u2019an People\u2019s Hospital - West China Ya\u2019an Hospital, Sichuan University","place":["Ya\u2019an, China"]},{"name":"Department of Gastroenterology and Hepatology, Ya\u2019an People\u2019s Hospital - West China Ya\u2019an Hospital, Sichuan University","place":["Ya\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou","family":"Chen","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Ya\u2019an People\u2019s Hospital - West China Ya\u2019an Hospital, Sichuan University","place":["Ya\u2019an, China"]},{"name":"Department of Gastroenterology and Hepatology, Ya\u2019an People\u2019s Hospital - West China Ya\u2019an Hospital, Sichuan University","place":["Ya\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Zu","family":"Chen","sequence":"additional","affiliation":[{"name":"Gastric Cancer Center & Gastric Cancer Laboratory, Department of General Surgery, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Ya\u2019an Cancer Prevention and Control Center, Ya\u2019an People\u2019s Hospital - West China Ya\u2019an Hospital, Sichuan University","place":["Ya\u2019an, China"]},{"name":"Ya\u2019an Key Laboratory for High Altitude Medicine, Ya\u2019an People\u2019s Hospital - West China Ya\u2019an Hospital, Sichuan University","place":["Ya\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SIGES Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/S0140-6736(25)00052-2","article-title":"Gastric cancer","volume":"405","author":"Sundar","year":"2025","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1053\/j.gastro.2022.05.009","article-title":"Active eradication of within 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