{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:25:22Z","timestamp":1777890322484,"version":"3.51.4"},"reference-count":121,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006701","name":"Umm Al-Qura University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antimicrobial resistance (AMR) poses a major public health challenge in Pakistan due to irrational antibiotic use and weak surveillance. The WHO AWaRe framework and United Nations General Assembly (UNGA) declaration urge a 70% global use of Access antibiotics. This scoping review aims to assess whether current susceptibility patterns in Pakistan (2020\u20132024) support achieving or maintaining the 70% Access target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PRISMA-ScR\u2013based scoping review identified 2020\u20132024 studies reporting susceptibility of WHO Access antibiotics in Pakistan. Eligible studies included human clinical isolates tested by standardized antimicrobial susceptibility methods. Weighted pathogen-antibiotic-year-wise susceptibilities were analyzed, along with pathogen-and WHO ATC (anatomical therapeutic chemical classification) class\u2013wise temporal trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 74 studies published between 2020 and 2024 were included. Most studies were conducted in Punjab. Overall, the susceptibility of WHO Access antibiotics remained low across major pathogens.\n                      <jats:italic>S. aureus<\/jats:italic>\n                      and Pseudomonas spp showed notable declines, while\n                      <jats:italic>E. coli<\/jats:italic>\n                      has shown variable susceptibility. Among WHO ATC classes, aminoglycosides, beta lactams, and cephalosporins demonstrated low susceptibility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This scoping review revealed that persistently low susceptibility to Access antibiotics in Pakistan challenges the feasibility of the WHO's 70% utilization target. Strengthening surveillance programs is essential to curb AMR and align national efforts with global antibiotic use targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1778876","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:27Z","timestamp":1777613727000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Pakistan achieve the UNGA 70% antibiotic access target? A scoping review of susceptibility data"],"prefix":"10.3389","volume":"14","author":[{"given":"Fiza","family":"Benish","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University","place":["Multan, Punjab, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zikria","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, Qassim University","place":["Buraydah, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shairyar","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, DHQ Hospital Jhelum","place":["Jhelum, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Arooj","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University","place":["Multan, Punjab, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud E.","family":"Elrggal","sequence":"additional","affiliation":[{"name":"College of Medicine, Al Qunfudah Umm Al-Qura University","place":["Makkah, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Haseeb","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk","place":["Tabuk, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.3390\/healthcare11131946","article-title":"Antimicrobial resistance: a growing serious threat for global public 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