{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:17:39Z","timestamp":1788895059294,"version":"build-2803163510"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["D18007"],"award-info":[{"award-number":["D18007"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Skin aging is a complex, multifactorial biological process that can be significantly accelerated by environmental toxicants such as cadmium (Cd), a highly toxic and ubiquitous heavy metal. Although the broad cytotoxic impacts of Cd have been extensively reported, a comprehensive understanding of the precise molecular pathways underlying Cd-induced skin senescence is still lacking. In this study, we investigated the protective role of Sirtuin 1 (SIRT1), a highly conserved nicotinamide adenine dinucleotide (NAD\n                      <jats:sup>+<\/jats:sup>\n                      )-dependent deacetylase that functions as a master regulator of mitochondrial homeostasis and cellular defense mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To delineate the influence of SIRT1 on dermal aging, we established an\n                      <jats:italic>in vitro<\/jats:italic>\n                      model using primary rat dermal fibroblasts and C3H\/10\u202fT1\/2 cells, where SIRT1 levels were modulated via lentiviral-mediated overexpression. Concurrently, an\n                      <jats:italic>in vivo<\/jats:italic>\n                      model was developed using Sprague\u2013Dawley rats subjected to chronic Cd exposure via drinking water (50\u202fmg\/L) for 6\u202fmonths, complemented by skin-targeted SIRT1 upregulation through the local injection of AAV-r-SIRT1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results demonstrate that Cd exposure elevates reactive oxygen species (ROS), disrupts mitochondrial integrity, and activates DNA damage responses, collectively driving cellular senescence. SIRT1 was shown to exert protective effects through the deacetylation of key substrates such as P53 and SOD2, thereby restoring redox balance and promoting DNA repair. The elevation of SIRT1 expression markedly mitigated mitochondrial impairments, senescent phenotypes, and apoptotic features triggered by Cd exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings position SIRT1 as a crucial regulator of Cd-induced skin aging and suggest that targeting this deacetylase may provide a viable strategy to counteract skin degeneration caused by environmental insults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1779372","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:47:19Z","timestamp":1771915639000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["SIRT1 regulates dermal fibroblast senescence via impaired deacetylase function and mitochondrial dysfunction during skin aging induced by chronic oral cadmium exposure"],"prefix":"10.3389","volume":"14","author":[{"given":"Dehui","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengsheng","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunchao","family":"Su","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Ran","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Southwest University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongping","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University","place":["Yangzhou, Jiangsu, China"]},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, Jiangsu, China"]},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/398_2016_8","article-title":"Cadmium bioavailability, uptake, toxicity and detoxification in soil-plant system","volume":"241","author":"Shahid","year":"2017","journal-title":"Rev Environ Contam Toxicol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"136914","DOI":"10.1016\/j.chemosphere.2022.136914","article-title":"Remediation of cadmium or arsenic contaminated water and soil by modified biochar: a review","volume":"311","author":"Zhang","year":"2023","journal-title":"Chemosphere"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1093\/carcin\/bgaa076","article-title":"Metals and molecular carcinogenesis","volume":"41","author":"Zhu","year":"2020","journal-title":"Carcinogenesis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tox.2017.05.018","article-title":"Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability","volume":"387","author":"Luz","year":"2017","journal-title":"Toxicology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/15287394.2018.1485122","article-title":"Biochemical and transcriptional analyses of cadmium-induced mitochondrial dysfunction and oxidative stress in human osteoblasts","volume":"81","author":"Monteiro","year":"2018","journal-title":"J Toxicol Environ Health A"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00204-024-03903-2","article-title":"Heavy metals: toxicity and human health effects","volume":"99","author":"Jomova","year":"2025","journal-title":"Arch Toxicol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.toxlet.2020.11.008","article-title":"Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues","volume":"337","author":"Popov Aleksandrov","year":"2021","journal-title":"Toxicol Lett"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e0171821","DOI":"10.1128\/AEM.01718-21","article-title":"The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance","volume":"87","author":"Alquethamy","year":"2021","journal-title":"Appl Environ Microbiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.fsi.2020.12.013","article-title":"Immunity and inflammatory responses in gilthead sea bream (Sparus aurata L.) exposed to sub-lethal mixture of carbamazepine, cadmium chloride and polybrominated diphenyl ether","volume":"111","author":"Espinosa-Ruiz","year":"2021","journal-title":"Fish Shellfish Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.scitotenv.2019.06.405","article-title":"Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation","volume":"689","author":"Ge","year":"2019","journal-title":"Sci Total Environ"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"143180","DOI":"10.1016\/j.chemosphere.2024.143180","article-title":"Cadmium neurotoxicity: insights into behavioral effect and neurodegenerative diseases","volume":"364","author":"Rezaei","year":"2024","journal-title":"Chemosphere"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"118890","DOI":"10.1016\/j.envres.2024.118890","article-title":"Health risk assessment of heavy metal(loid)s in road dust via dermal exposure pathway from a low latitude plateau provincial capital city: the importance of toxicological verification","volume":"252","author":"Li","year":"2024","journal-title":"Environ Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"14459","DOI":"10.3390\/ijms241914459","article-title":"Mitochondrial oxidative stress is the general reason for apoptosis induced by different-valence heavy metals in cells and mitochondria","volume":"24","author":"Korotkov","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"S231","DOI":"10.1016\/j.jid.2023.03.1366","article-title":"1350 the role of mitochondria in skin aging","volume":"143","author":"Yamamura","year":"2023","journal-title":"J Invest Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12974-021-02250-8","article-title":"NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1\/PGC-1\u03b1 pathway","volume":"18","author":"Zhao","year":"2021","journal-title":"J Neuroinflammation"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12933-024-02183-5","article-title":"Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53","volume":"23","author":"Tang","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s10856-022-06684-1","article-title":"Silibinin-modified hydroxyapatite coating promotes the osseointegration of titanium rods by activation SIRT1\/SOD2 signaling pathway in diabetic rats","volume":"33","author":"Tao","year":"2022","journal-title":"J Mater Sci Mater Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.4155\/fmc-2021-0136","article-title":"TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation","volume":"14","author":"Liu","year":"2022","journal-title":"Future Med Chem"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/tox.23724","article-title":"Cadmium induces mitochondrial dysfunction via SIRT1 suppression-mediated oxidative stress in neuronal cells","volume":"38","author":"Wen","year":"2023","journal-title":"Environ Toxicol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e002171","DOI":"10.1136\/openhrt-2022-002171","article-title":"Nutraceutical activation of Sirt1: a review","volume":"9","author":"DiNicolantonio","year":"2022","journal-title":"Open Heart"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"155533","DOI":"10.1016\/j.phymed.2024.155533","article-title":"Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1\/p53 axis","volume":"128","author":"Zeng","year":"2024","journal-title":"Phytomedicine"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"102745","DOI":"10.1016\/j.redox.2023.102745","article-title":"\u0392-Nicotinamide mononucleotide activates NAD+\/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice","volume":"63","author":"Li","year":"2023","journal-title":"Redox Biol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/(SICI)1097-4652(199905)179:2%3C218::AID-JCP12%3E3.0.CO;2-U","article-title":"Peroxisome proliferation, adipocyte determination and differentiation of C3H10T1\/2 fibroblast cells induced by humic acid: induction of PPAR in diverse cells","volume":"179","author":"Lee","year":"1999","journal-title":"J Cell Physiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"129568","DOI":"10.1016\/j.bbagen.2020.129568","article-title":"Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1\/2Cl8 mouse embryonic fibroblasts","volume":"1864","author":"Oldani","year":"2020","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.3390\/ijms24043674","article-title":"Basic methods of cell cycle analysis","volume":"24","author":"Ligasov\u00e1","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.1016\/j.cell.2024.05.059","article-title":"Guidelines for minimal information on cellular senescence experimentation in vivo","volume":"187","author":"Ogrodnik","year":"2024","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s00125-020-05307-0","article-title":"Senescence-associated \u03b2-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity","volume":"64","author":"Rouault","year":"2021","journal-title":"Diabetologia"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10534-025-00665-x","article-title":"Heavy metal-induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders","volume":"38","author":"Das","year":"2025","journal-title":"Biometals"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"911","DOI":"10.3390\/brainsci13060911","article-title":"Distribution of Iron, copper, zinc and cadmium in glia, their influence on glial cells and relationship with neurodegenerative diseases","volume":"13","author":"G\u00f3rska","year":"2023","journal-title":"Brain Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"109961","DOI":"10.1016\/j.cbi.2022.109961","article-title":"Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation","volume":"361","author":"Hern\u00e1ndez-Cruz","year":"2022","journal-title":"Chem Biol Interact"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"159959","DOI":"10.1016\/j.scitotenv.2022.159959","article-title":"Trends in hepatic cadmium concentrations in marine bird species from the Canadian Arctic","volume":"858","author":"Bianchini","year":"2023","journal-title":"Sci Total Environ"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"136063","DOI":"10.1100\/2012\/136063","article-title":"Mitochondrial electron transport chain in heavy metal-induced neurotoxicity: effects of cadmium, mercury, and copper","volume":"2012","author":"Belyaeva","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"113148","DOI":"10.1016\/j.celrep.2023.113148","article-title":"Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes","volume":"42","author":"Focken","year":"2023","journal-title":"Cell Rep"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1515\/jbcpp-2021-0173","article-title":"Pathophysiological effects of cadmium(II) on human health-a critical review","volume":"34","author":"Bhattacharyya","year":"2023","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00204-014-1430-4","article-title":"Biology of the cell cycle inhibitor p21(CDKN1A): molecular mechanisms and relevance in chemical toxicology","volume":"89","author":"Dutto","year":"2015","journal-title":"Arch Toxicol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/978-3-662-41088-2_33","article-title":"Cadmium-induced nephropathy in rats is mediated by expression of senescence-associated beta-galactosidase and accumulation of mitochondrial DNA deletion","volume":"1011","author":"Takaki","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"500","DOI":"10.3390\/brainsci13030500","article-title":"Among gerontogens, heavy metals are a class of their own: a review of the evidence for cellular senescence","volume":"13","author":"Vielee","year":"2023","journal-title":"Brain Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1272191","DOI":"10.3389\/fimmu.2023.1272191","article-title":"Wound healing and cadmium detoxification in the earthworm Lumbricus terrestris - a potential case for coelomocytes?","volume":"14","author":"Aigner","year":"2023","journal-title":"Front Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e02436","DOI":"10.1002\/advs.202502436","article-title":"Regenerative hair pigmentation via skin organoids: adaptive patterning mediated by collagen VI and Semaphorin 3C","volume":"12","author":"Li","year":"","journal-title":"Adv Sci (Weinh)"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.2174\/1389201024666221223095315","article-title":"Novel Nanotechnological strategies for skin anti-aging","volume":"24","author":"Pozos-Nonato","year":"2023","journal-title":"Curr Pharm Biotechnol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.3390\/biom11111575","article-title":"Cadmium-induced kidney injury: oxidative damage as a unifying mechanism","volume":"11","author":"Yan","year":"2021","journal-title":"Biomolecules"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"101507","DOI":"10.1016\/j.arr.2021.101507","article-title":"Stress and telomere shortening: insights from cellular mechanisms","volume":"73","author":"Lin","year":"2022","journal-title":"Ageing Res Rev"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"109298","DOI":"10.1016\/j.abb.2022.109298","article-title":"On \u201cUbisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria\u201d by Julio F. Turrens, Adolfo Alexandre and Albert L. Lehninger","volume":"726","author":"Turrens","year":"2022","journal-title":"Arch Biochem Biophys"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1177\/0960327110384286","article-title":"Cadmium directly induced mitochondrial dysfunction of human embryonic kidney cells","volume":"30","author":"Mao","year":"2011","journal-title":"Hum Exp Toxicol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1080\/24750263.2021.1912199","article-title":"Effects of cadmium on mitochondrial structure and function in different organs: studies on the soil centipede Lithobius forficatus (Myriapoda, Chilopoda)","volume":"88","author":"Rost-Roszkowska","year":"2021","journal-title":"Eur Zool J"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.3390\/ijerph17113782","article-title":"The effects of cadmium toxicity","volume":"17","author":"Genchi","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"13283","DOI":"10.3390\/ijms252413283","article-title":"Cadmium-induced oxidative damage and the expression and function of mitochondrial Thioredoxin in Phascolosoma esculenta","volume":"25","author":"Gu","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1016\/j.envpol.2017.09.044","article-title":"ATM signals to AMPK to promote autophagy and positively regulate DNA damage in response to cadmium-induced ROS in mouse spermatocytes","volume":"231","author":"Li","year":"2017","journal-title":"Environ Pollut"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.biochi.2006.10.001","article-title":"Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review)","volume":"88","author":"Bertin","year":"2006","journal-title":"Biochimie"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"111789","DOI":"10.1016\/j.cbi.2025.111789","article-title":"Environmental chromium and cadmium co-exposure induces GADD45A-mediated rDNA instability in human cohorts and cell models","volume":"422","author":"Li","year":"2025","journal-title":"Chem Biol Interact"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/cells10030640","article-title":"Cadmium (II)-induced oxidative stress results in replication stress and epigenetic modifications in root meristem cell nuclei of Vicia faba","volume":"10","author":"\u017babka","year":"2021","journal-title":"Cells"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"110632","DOI":"10.1016\/j.cbi.2023.110632","article-title":"SIRT1 regulates osteoblast senescence through SOD2 acetylation and mitochondrial dysfunction in the progression of osteoporosis caused by cadmium exposure","volume":"382","author":"Zhou","year":"2023","journal-title":"Chem Biol Interact"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1161\/CIRCRESAHA.122.320888","article-title":"Targeting SIRT1 rescues age- and obesity-induced microvascular dysfunction in ex vivo human vessels","volume":"131","author":"Mengozzi","year":"2022","journal-title":"Circ Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/s41556-020-00579-5","article-title":"SIRT1 is downregulated by autophagy in senescence and ageing","volume":"22","author":"Xu","year":"2020","journal-title":"Nat Cell Biol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"299","DOI":"10.2174\/1567202614666170718092010","article-title":"Moving to the rhythm with clock (circadian) genes, autophagy, mTOR, and SIRT1 in degenerative disease and Cancer","volume":"14","author":"Maiese","year":"2017","journal-title":"Curr Neurovasc Res"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"6754","DOI":"10.1093\/nar\/gkad504","article-title":"SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex","volume":"51","author":"Rasti","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"8840","DOI":"10.3390\/ijms21228840","article-title":"The aging stress response and its implication for AMD pathogenesis","volume":"21","author":"Blasiak","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"110038","DOI":"10.1016\/j.celrep.2021.110038","article-title":"LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity","volume":"37","author":"Yan","year":"2021","journal-title":"Cell Rep"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","article-title":"Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis","volume":"155","author":"Yuan","year":"2016","journal-title":"Mech Ageing Dev"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"511","DOI":"10.4062\/biomolther.2017.119","article-title":"Aquatide activation of SIRT1 reduces cellular senescence through a SIRT1-FOXO1-autophagy Axis","volume":"25","author":"Lim","year":"2017","journal-title":"Biomol Ther (Seoul)"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"23286","DOI":"10.1021\/acs.jafc.4c05945","article-title":"Enhanced SIRT1 activity by Galangin mitigates UVB-induced senescence in dermal fibroblasts via p53 acetylation regulation and activation","volume":"72","author":"Wen","year":"2024","journal-title":"J Agric Food Chem"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.3390\/cells10092204","article-title":"Role of MicroRNA in inflammatory bowel disease: clinical evidence and the development of preclinical animal models","volume":"10","author":"Suri","year":"2021","journal-title":"Cells"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12916-023-02878-8","article-title":"Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn\u2019s disease: a multi-omics Mendelian randomization study","volume":"21","author":"Xu","year":"2023","journal-title":"BMC Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"13676","DOI":"10.1038\/s41598-018-31785-9","article-title":"The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons","volume":"8","author":"Lee","year":"2018","journal-title":"Sci Rep"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"102545","DOI":"10.1016\/j.arr.2024.102545","article-title":"The role of sirtuin 1 in ageing and neurodegenerative disease: a molecular perspective","volume":"102","author":"Thapa","year":"2024","journal-title":"Ageing Res Rev"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2026.1779372\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:47:20Z","timestamp":1771915640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2026.1779372\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":65,"alternative-id":["10.3389\/fpubh.2026.1779372"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2026.1779372","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"article-number":"1779372"}}