{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:08:35Z","timestamp":1779170915043,"version":"3.51.4"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neonatal jaundice is one of the most common conditions leading to neonatal hospitalization and is a preventable cause of bilirubin-induced neurological dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to characterize the clinical profile of neonates with jaundice admitted to the People's Hospital of Atushi City, Xinjiang and to explore the clinical predictors of severe hyperbilirubinemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective observational study of all neonates (\u2264 28 days) admitted to the neonatal unit of the People's Hospital of Atushi City with jaundice. Demographic, perinatal, and clinical variables, including ethnicity, gestational age, birth weight, age at admission, feeding type, perinatal risk factors, total serum bilirubin (TSB) at admission and discharge, phototherapy and antibiotic use, and length of stay, were extracted from electronic medical records. Severe jaundice was defined as an admission TSB at or above the 75th percentile of the cohort distribution (348.7 \u03bcmol\/L). Early-onset jaundice was defined as an age at admission of \u2264 48 h. Multivariable logistic regression was applied to identify independent predictors of severe jaundice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 261 infants (57.1% male; 90.4% born at term), the mean gestational age was 39.2 \u00b1 1.2 weeks, and the mean birth weight was 3.35 \u00b1 0.52 kg. Uyghur infants comprised 82.8% of the cohort, and Han infants comprised 9.6%. The mean admission TSB was 298.1 \u00b1 79.1 \u03bcmol\/L; 22.6% of infants met the definition of severe jaundice. The proportion of severe jaundice was 27.9% among Uyghur infants and 20.0% among Han infants. In adjusted analysis, early-onset jaundice was associated with lower odds of severe hyperbilirubinemia (odds ratio [OR] 0.12, 95% confidence interval [CI] 0.01\u20130.98), whereas pre-term birth showed a non-significant trend toward increased risk (OR 4.03, 95% CI 0.85\u201319.23). Ethnicity was not an independent predictor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Severe neonatal jaundice is common among hospitalized infants in Atushi, Xinjiang, with higher crude proportions in Uyghur infants than in Han infants. After adjustment for clinical factors, early recognition and timely admission, rather than ethnicity\n                      <jats:italic>per se<\/jats:italic>\n                      , appear to be the most important factors in preventing severe hyperbilirubinemia. These findings should be interpreted with caution and validated in larger multicenter cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1785255","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:39:51Z","timestamp":1779169191000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological characteristics and clinical predictors of neonatal jaundice in a multi- ethnic population in Xinjiang, China: a retrospective study"],"prefix":"10.3389","volume":"14","author":[{"given":"Junyi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The People's Hospital of Atushi","place":["Atushi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The People's Hospital of Atushi","place":["Atushi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The People's Hospital of Atushi","place":["Atushi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The People's Hospital of Atushi","place":["Atushi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patigul","family":"Ablet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The People's Hospital of Atushi","place":["Atushi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanfu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maternal and Child Health Care Hospital of Kunshan","place":["Kunshan, 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