{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:10:14Z","timestamp":1773645014036,"version":"3.50.1"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The world continues to face major health risks through childhood malnutrition and rickets and anemia which hinder the development of physical and mental and immune system functions. The public health system needs to study determinants of health problems and their effective solutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our research team evaluated 96 studies, which include 153,694 participants from the Middle East and Africa and South and Southeast Asia and high-latitude regions through systematic review. The research team searched for studies in PubMed, Web of Science, Embase, Cochrane Library, and Google Scholar. The research team included observational studies and RCTs and cohort studies and individual participant data meta-analyses in their investigation. The study team evaluated research quality and bias risk through the use of Jadad scale and GRADE system and standard evaluation tools. The research team conducted random-effects meta-analyses to combine hazard ratio data while they used funnel plots and Egger\u2019s test to check for publication bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study found that Childhood Nutritional Rickets and Vitamin D\/Calcium Status showed strong associations with low calcium and vitamin D intake (HR 1.51, 95% CI 1.26\u20131.82; I\n                      <jats:sup>2<\/jats:sup>\n                      =\u202f88%). The research team found that three programs which included Childhood Malnutrition Prevention and Micronutrient Supplementation and Maternal\/Early Childhood Nutrition Programs showed protective effects (HR 0.80, 95% CI 0.77\u20130.84; I\n                      <jats:sup>2<\/jats:sup>\n                      =\u202f0%; HR 0.91, 95% CI 0.86\u20130.96; I\n                      <jats:sup>2<\/jats:sup>\n                      =\u202f22%; HR 0.85, 95% CI 0.78\u20130.93; I\n                      <jats:sup>2<\/jats:sup>\n                      =\u202f53%). The research team used long-term observational studies to demonstrate persistent malnutrition without significant pooled effects (HR 0.96, 95% CI 0.90\u20131.01; I\n                      <jats:sup>2<\/jats:sup>\n                      =\u202f10%). Publication bias was found in Groups 1\u20134 (Egger\u2019s\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001\u20130.001), publication bias was not found in Group 5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.054).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of calcium and vitamin D supplements with targeted micronutrients and integrated maternal-child programs effectively decreases rickets and malnutrition while it enhances global growth rate. The implementation of programs requires specific contextual understanding for achieving the best health results in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1786959","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:37:43Z","timestamp":1773643063000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Childhood malnutrition, rickets, and anemia: a systematic review and meta-analysis on global prevalence, determinants, and public health implications"],"prefix":"10.3389","volume":"14","author":[{"given":"Yajuan","family":"Tan","sequence":"first","affiliation":[{"name":"Traditional Chinese Medicine Pediatrics, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture","place":["Enshi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1017\/S0007114522001477","article-title":"Daily v. weekly oral vitamin D3 therapy for nutritional rickets in Indian children: a randomised controlled open-label trial","volume":"129","author":"Dabas","year":"2023","journal-title":"Br J Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e2023063263","DOI":"10.1542\/peds.2023-063263","article-title":"Maternal vitamin D supplementation and infantile rickets: secondary analysis of a randomized trial","volume":"153","author":"Lautatzis","year":"2024","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1002\/jbmr.4888","article-title":"Health effects of vitamin D supplementation: lessons learned from randomized controlled trials and Mendelian randomization studies","volume":"38","author":"Bouillon","year":"2023","journal-title":"J Bone Miner Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00394-025-03706-w","article-title":"Prevention of chronic disease using vitamins\u2014a case study of the vitamin D and cardiovascular disease hypothesis using evidence from randomised controlled and prospective cohort studies","volume":"64","author":"Kiely","year":"2025","journal-title":"Eur J Nutr"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2022.100035","article-title":"Effectiveness of nutritional supplementation during the first 1000-days of life to reduce child undernutrition: a cluster randomized controlled trial in Pakistan","volume":"4","author":"Soofi","year":"2022","journal-title":"Lancet Regional Health"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.ajcnut.2023.01.019","article-title":"Probiotics for children with uncomplicated severe acute malnutrition (PruSAM study): a randomized controlled trial in the Democratic Republic of Congo","volume":"117","author":"Kambale","year":"2023","journal-title":"Am J Clin Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1186\/s12889-022-14398-w","article-title":"School water, sanitation, and hygiene (WaSH) intervention to improve malnutrition, dehydration, health literacy, and handwashing: a cluster-randomised controlled trial in metro Manila, Philippines","volume":"22","author":"Sangalang","year":"2022","journal-title":"BMC Public Health"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e0275357","DOI":"10.1371\/journal.pone.0275357","article-title":"A nutrition programme using positive deviance approach to reduce undernutrition among urban poor children under-five in Malaysia: a cluster randomised controlled trial protocol","volume":"17","author":"Chek","year":"2022","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1017\/S0007114521002713","article-title":"Low dose depot oral vitamin D3v. 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