{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:18:08Z","timestamp":1775650688228,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited research exists on revealing the correlation between laboratory safety tests and real-world safety feedback from consumers of cosmetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To establish cosmetovigilance by associating patch test results with consumer-reported adverse reaction (CRARs) feedback form e-commerce feedback for cosmetics targeting sensitive skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patch tests were performed on a cohort of sensitive-skin cosmetics, and CRARs were extracted from e-commerce comments. A generalized linear model was utilized to analyze the association between patch test results and CRARs, considering functional claims and application modes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the patch test results of 64 cosmetics, 42 exhibited negative reactions, 21 showed doubtful reactions, and one cosmetic demonstrated a weak positive reaction. The model established with a warning threshold of two doubtful reactions proved to be optimal. Patch test results were associated with sensitization-related and pain-related CRARs, but not with acnegenic-related CRARs. Brightening and acne treatment cosmetics exhibited higher acnegenic and pain rates, while leave-on cosmetics had a higher sensitization rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The data-driven results show that cosmetics with 2 or more doubtful reactions in patch test have a significantly correlation with real-world CRARs, which reminds relevant practitioners to be more cautious about doubtful reactions in patch test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1791667","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:37:01Z","timestamp":1775648221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From laboratory to real-world exposure: correlating cosmetic patch test results with large-scale consumer safety data from e-commerce platforms"],"prefix":"10.3389","volume":"14","author":[{"given":"Kai","family":"Yang","sequence":"first","affiliation":[{"name":"Shanghai Jiyan Biomedical Development Co., Ltd.","place":["Shanghai, China"]},{"name":"Yunnan Botanee Bio-technology Group Co., Ltd.","place":["Yunnan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiyan Biomedical Development Co., Ltd.","place":["Shanghai, China"]},{"name":"Yunnan Botanee Bio-technology Group Co., Ltd.","place":["Yunnan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dangdang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai Jiyan Biomedical Development Co., Ltd.","place":["Shanghai, China"]},{"name":"Yunnan Botanee Bio-technology Group Co., Ltd.","place":["Yunnan, 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